HK1246303A1 - 反义抗菌化合物和方法 - Google Patents
反义抗菌化合物和方法 Download PDFInfo
- Publication number
- HK1246303A1 HK1246303A1 HK18105904.4A HK18105904A HK1246303A1 HK 1246303 A1 HK1246303 A1 HK 1246303A1 HK 18105904 A HK18105904 A HK 18105904A HK 1246303 A1 HK1246303 A1 HK 1246303A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- methods
- antibacterial compounds
- antisense
- antisense antibacterial
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3233—Morpholino-type ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462098713P | 2014-12-31 | 2014-12-31 | |
| US62/098,713 | 2014-12-31 | ||
| PCT/US2015/000280 WO2016108930A2 (en) | 2014-12-31 | 2015-12-23 | Antisense antibacterial compounds and methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1246303A1 true HK1246303A1 (zh) | 2018-09-07 |
Family
ID=56285129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18105904.4A HK1246303A1 (zh) | 2014-12-31 | 2015-12-23 | 反义抗菌化合物和方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11293024B2 (https=) |
| EP (1) | EP3240794A4 (https=) |
| JP (2) | JP6994941B2 (https=) |
| AU (1) | AU2015372560B2 (https=) |
| CA (2) | CA3249464A1 (https=) |
| HK (1) | HK1246303A1 (https=) |
| WO (1) | WO2016108930A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9790495B2 (en) | 2014-05-16 | 2017-10-17 | Oregon State University | Antisense antibacterial compounds and methods |
| AU2015264449B2 (en) | 2014-05-19 | 2022-05-05 | Board Of Regents, The University Of Texas System | Antisense antibacterial compounds and methods |
| CA3249464A1 (en) | 2014-12-31 | 2025-11-29 | Univ Texas | Antisense antibacterial compounds and methods |
| AU2016379402B2 (en) | 2015-12-23 | 2023-01-12 | Board Of Regents, The University Of Texas System | Antisense antibacterial compounds and methods |
| AU2016379399B2 (en) | 2015-12-23 | 2022-12-08 | Board Of Regents, The University Of Texas System | Antisense antibacterial compounds and methods |
| WO2020035619A1 (en) * | 2018-08-17 | 2020-02-20 | Centre National De La Recherche Scientifique (Cnrs) | Rna-based biocontrol methods to protect plants against pathogenic bacteria and / or promote beneficial effects of symbiotic and commensal bacteria |
| GB2579253A (en) | 2018-11-28 | 2020-06-17 | Pedanius Therapeutics Ltd | Antibacterial antisense agents |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5668616A (en) * | 1979-11-08 | 1981-06-09 | Yukio Kimura | Preparation of antibiotic composition |
| US5217866A (en) | 1985-03-15 | 1993-06-08 | Anti-Gene Development Group | Polynucleotide assay reagent and method |
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5521063A (en) | 1985-03-15 | 1996-05-28 | Antivirals Inc. | Polynucleotide reagent containing chiral subunits and methods of use |
| US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
| JP3022967B2 (ja) | 1985-03-15 | 2000-03-21 | アンチバイラルズ インコーポレイテッド | 立体規則性ポリヌクレオチド結合ポリマー |
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| WO1993001286A2 (en) | 1991-06-28 | 1993-01-21 | Massachusetts Institute Of Technology | Localized oligonucleotide therapy |
| ATE330644T1 (de) | 1995-12-18 | 2006-07-15 | Angiotech Biomaterials Corp | Vernetzten polymerisatmassen und verfahren für ihre verwendung |
| US6245747B1 (en) | 1996-03-12 | 2001-06-12 | The Board Of Regents Of The University Of Nebraska | Targeted site specific antisense oligodeoxynucleotide delivery method |
| WO1998050557A1 (en) * | 1997-05-02 | 1998-11-12 | University Of Guelph | Proteins involved in the synthesis and assembly of core lipopolysaccharide of pseudomonas aeruginosa |
| WO2000015265A1 (en) * | 1998-09-16 | 2000-03-23 | Vitagenix, Inc. | Compositions and methods of use of uptake mechanisms for diagnostic and therapeutic applications of oligonucleotides targeting bacteria |
| US20040033972A1 (en) * | 2000-12-20 | 2004-02-19 | Horwitz Marcus A. | Treatment of mycobacterium tuberculosis with antisense polynucleotides |
| US20060241075A1 (en) | 2001-05-18 | 2006-10-26 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of desmoglein gene expression using short interfering nucleic acid (siNA) |
| US20040029129A1 (en) | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
| US6965025B2 (en) | 2001-12-10 | 2005-11-15 | Isis Pharmaceuticals, Inc. | Antisense modulation of connective tissue growth factor expression |
| AU2004231740A1 (en) | 2003-04-17 | 2004-11-04 | The Trustees Of Columbia University In The City Ofnew York | Desmoglein 4 is a novel gene involved in hair growth |
| CA2523672C (en) | 2003-04-29 | 2012-07-17 | Avi Biopharma, Inc. | Compositions for enhancing transport of molecules into cells |
| US20050288246A1 (en) | 2004-05-24 | 2005-12-29 | Iversen Patrick L | Peptide conjugated, inosine-substituted antisense oligomer compound and method |
| ATE510914T1 (de) | 2004-07-02 | 2011-06-15 | Avi Biopharma Inc | Antisinn antibakterielle verfahren und verbindungen |
| US20060263798A1 (en) | 2005-02-11 | 2006-11-23 | International Business Machines Corporation | System and method for identification of MicroRNA precursor sequences and corresponding mature MicroRNA sequences from genomic sequences |
| US7790694B2 (en) | 2005-07-13 | 2010-09-07 | Avi Biopharma Inc. | Antisense antibacterial method and compound |
| US8067571B2 (en) * | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| CA2614191C (en) | 2005-07-13 | 2015-06-30 | Avi Biopharma, Inc. | Antisense antibacterial method and compound |
| WO2007025016A1 (en) | 2005-08-25 | 2007-03-01 | Texas Tech University System | Inhibition of metallo-beta-lactamase by double-stranded dna |
| EP3443976A1 (en) * | 2007-06-29 | 2019-02-20 | Sarepta Therapeutics, Inc. | Tissue specific peptide conjugates and methods |
| US20100016215A1 (en) * | 2007-06-29 | 2010-01-21 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| MX2010004955A (es) | 2007-11-15 | 2010-06-30 | Avi Biopharma Inc | Metodo de sintesis de oligomeros de morfolina. |
| US8299206B2 (en) | 2007-11-15 | 2012-10-30 | Avi Biopharma, Inc. | Method of synthesis of morpholino oligomers |
| US8076476B2 (en) | 2007-11-15 | 2011-12-13 | Avi Biopharma, Inc. | Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits |
| WO2009139635A1 (en) * | 2008-05-15 | 2009-11-19 | Prosensa Technologies B.V. | Polymyxin derivatives and uses thereof |
| WO2010134939A2 (en) * | 2008-12-19 | 2010-11-25 | Zirus, Inc. | Mammalian genes involved in infection |
| US20110269665A1 (en) | 2009-06-26 | 2011-11-03 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| WO2011018798A2 (en) | 2009-08-14 | 2011-02-17 | Indian Association For The Cultivation Of Science | Morpholino-based antisense agent |
| WO2012031243A2 (en) | 2010-09-03 | 2012-03-08 | Avi Biopharma, Inc. | dsRNA MOLECULES COMPRISING OLIGONUCLEOTIDE ANALOGS HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS |
| RS55610B1 (sr) | 2010-09-30 | 2017-06-30 | Nippon Shinyaku Co Ltd | Derivat morfolino nukleinske kiseline |
| EP3067420A1 (en) | 2010-11-12 | 2016-09-14 | Sarepta Therapeutics, Inc. | Antisense antibacterial compounds and methods |
| US20120213663A1 (en) | 2011-02-23 | 2012-08-23 | King Fahd University Of Petroleum And Minerals | Method of removing e. coli bacteria from an aqueous solution |
| US9161948B2 (en) * | 2011-05-05 | 2015-10-20 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| WO2012150960A1 (en) | 2011-05-05 | 2012-11-08 | Avi Biopharma, Inc. | Peptide oligonucleotide conjugates |
| KR101317263B1 (ko) | 2011-07-05 | 2013-10-10 | (주)지노첵 | 리얼타임 ｐｃｒ을 이용한 카바페넴 내성 장내균 검사 방법 및 키트 |
| WO2013011072A1 (en) | 2011-07-20 | 2013-01-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Carbapenemase and antibacterial treatment |
| EA202090338A1 (ru) * | 2011-11-18 | 2021-04-30 | Сарепта Терапьютикс, Инк. | Функционально-модифицированные олигонуклеотиды и их субъединицы |
| KR101450751B1 (ko) * | 2012-07-05 | 2014-10-16 | 서강대학교산학협력단 | 미생물을 이용한 지방산 제조 방법 |
| US9790495B2 (en) | 2014-05-16 | 2017-10-17 | Oregon State University | Antisense antibacterial compounds and methods |
| AU2015264449B2 (en) | 2014-05-19 | 2022-05-05 | Board Of Regents, The University Of Texas System | Antisense antibacterial compounds and methods |
| CA3249464A1 (en) | 2014-12-31 | 2025-11-29 | Univ Texas | Antisense antibacterial compounds and methods |
| AU2016379399B2 (en) | 2015-12-23 | 2022-12-08 | Board Of Regents, The University Of Texas System | Antisense antibacterial compounds and methods |
| AU2016379402B2 (en) | 2015-12-23 | 2023-01-12 | Board Of Regents, The University Of Texas System | Antisense antibacterial compounds and methods |
-
2015
- 2015-12-23 CA CA3249464A patent/CA3249464A1/en active Pending
- 2015-12-23 HK HK18105904.4A patent/HK1246303A1/zh unknown
- 2015-12-23 JP JP2017535019A patent/JP6994941B2/ja active Active
- 2015-12-23 EP EP15875820.1A patent/EP3240794A4/en active Pending
- 2015-12-23 CA CA2972653A patent/CA2972653C/en active Active
- 2015-12-23 AU AU2015372560A patent/AU2015372560B2/en active Active
- 2015-12-23 WO PCT/US2015/000280 patent/WO2016108930A2/en not_active Ceased
- 2015-12-23 US US15/540,387 patent/US11293024B2/en active Active
-
2021
- 2021-12-14 JP JP2021202636A patent/JP2022040131A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP3240794A4 (en) | 2018-10-31 |
| US11293024B2 (en) | 2022-04-05 |
| WO2016108930A3 (en) | 2016-08-25 |
| AU2015372560A1 (en) | 2017-07-20 |
| JP2022040131A (ja) | 2022-03-10 |
| EP3240794A2 (en) | 2017-11-08 |
| CA2972653C (en) | 2025-05-06 |
| WO2016108930A2 (en) | 2016-07-07 |
| CA2972653A1 (en) | 2016-07-07 |
| JP2018506272A (ja) | 2018-03-08 |
| CA3249464A1 (en) | 2025-11-29 |
| JP6994941B2 (ja) | 2022-02-04 |
| US20190169609A1 (en) | 2019-06-06 |
| AU2015372560B2 (en) | 2021-12-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1246303A1 (zh) | 反义抗菌化合物和方法 | |
| EP3577127A4 (en) | TARGETED OLIGONUCLEOTIDES | |
| EP3326661B8 (en) | Bio-ink composition having improved physical and biological properties | |
| EP3368086A4 (en) | SKIN ADHESIVES, ANTIMICROBIAL COMPOSITIONS, ARTICLES AND METHODS OF USE THEREOF | |
| HK1254843B (zh) | 包含细菌菌株的组合物 | |
| WO2013120022A3 (en) | Treatment of hypoglycemia | |
| EP4545544A3 (en) | Modified crispr rna and modified single crispr rna and uses thereof | |
| WO2014052836A3 (en) | Methods and compositions for treating infection | |
| IL248959A0 (en) | Preparations and methods for the treatment and prevention of staphylococcus aureus infections | |
| EP3099298B8 (en) | Zidovudine combination therapies for treating microbial infections | |
| WO2015175977A3 (en) | Antisense antibacterial compounds and methods | |
| EP3569252A3 (en) | Antisense antibacterial compounds and methods | |
| WO2017059122A8 (en) | Methods of treating and preventing amyotrophic lateral sclerosis | |
| EP3119781A4 (en) | Compounds which inhibit rna polymerase, compositions including such compounds, and their use | |
| LT3377094T (lt) | Susilpninto virulentiškumo bakterijos, skirtos piktybinių solidinių navikų gydymui | |
| EP3584319A4 (en) | SINGLE-STRAND OLIGONUCLEOTIDE | |
| EP3268010A4 (en) | Compositions and methods for treating bacterial infection | |
| SMT201900692T1 (it) | Composizione per l'uso del trattamento delle infezioni batteriche | |
| EP3273797A4 (en) | Composition inhibiting gram-positive, pathogenic bacteria | |
| EP3190893A4 (en) | Compositions and methods for treating and preventing bacterial infections | |
| EP2982378A4 (en) | COMPOSITION FOR THE PREVENTION OR TREATMENT OF SEPSIS OR SEPTIC SHOCK WITH ADK PROTEIN AS AN ACTIVE SUBSTANCE | |
| BR112014032290A2 (pt) | composições e métodos para tratar ou prevenir infecção de pneumovírus e doenças associadas. | |
| EP3231439A4 (en) | Antibacterial composition containing adk protein as active ingredient, or composition for preventing or treating septicemia | |
| WO2017100645A3 (en) | Inhibitors of bacterial rna polymerase: arylpropanoyl, arylpropenoyl, and arylcyclopropanecarboxyl phloroglucinols | |
| EP3220920A4 (en) | Combination therapy effective against microorganisms, including drug resistant microorganisms |