HK1222648A1 - 作爲用於治療血栓栓塞病症的凝血酶抑制劑的三唑並吡啶 - Google Patents

作爲用於治療血栓栓塞病症的凝血酶抑制劑的三唑並吡啶

Info

Publication number
HK1222648A1
HK1222648A1 HK16110763.6A HK16110763A HK1222648A1 HK 1222648 A1 HK1222648 A1 HK 1222648A1 HK 16110763 A HK16110763 A HK 16110763A HK 1222648 A1 HK1222648 A1 HK 1222648A1
Authority
HK
Hong Kong
Prior art keywords
triazolopyridines
treatment
thrombin inhibitors
thromboembolic diseases
thromboembolic
Prior art date
Application number
HK16110763.6A
Other languages
English (en)
Inventor
Swen Allerheiligen
Anja Buchmller
Karen Engel
Christoph Gerdes
Kersten Matthias Gericke
Michael Gerisch
Stefan Heitmeier
Alexander Hillisch
Tom Kinzel
Philip Lienau
Bernd Riedl
Susanne Rhrig
Martina Victoria Schmidt
Julia Stragouburger
Adrian Tersteegen
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of HK1222648A1 publication Critical patent/HK1222648A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK16110763.6A 2013-06-03 2016-09-12 作爲用於治療血栓栓塞病症的凝血酶抑制劑的三唑並吡啶 HK1222648A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13170211 2013-06-03
PCT/EP2014/061307 WO2014195244A1 (de) 2013-06-03 2014-06-02 Triazolopyridine als thrombininhibitoren zur behandlung von thromboembolischen erkrankungen

Publications (1)

Publication Number Publication Date
HK1222648A1 true HK1222648A1 (zh) 2017-07-07

Family

ID=48534287

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16110763.6A HK1222648A1 (zh) 2013-06-03 2016-09-12 作爲用於治療血栓栓塞病症的凝血酶抑制劑的三唑並吡啶

Country Status (7)

Country Link
US (1) US20160108039A1 (zh)
EP (1) EP3004095A1 (zh)
JP (1) JP2016520113A (zh)
CN (1) CN105408331A (zh)
CA (1) CA2914040A1 (zh)
HK (1) HK1222648A1 (zh)
WO (1) WO2014195244A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019057946A1 (en) 2017-09-25 2019-03-28 F. Hoffmann-La Roche Ag MULTI-CYCLIC AROMATIC COMPOUNDS AS D-FACTOR INHIBITORS
CN112654608B (zh) 2018-07-05 2024-05-07 桑福德伯纳姆普利斯医学发现研究所 具有脲结构的稠环化合物
AU2022401801A1 (en) * 2021-12-02 2024-06-13 Beigene, Ltd. Methods of synthesis of chiral 3, 5-disubstituted morpholine compounds and intermediates useful therein

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303625B1 (en) * 1998-07-27 2001-10-16 Ortho-Mcneil Pharmaceutical, Inc. Triazolopyridines for the treatment of thrombosis disorders
DE19962924A1 (de) * 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
DE10220570A1 (de) * 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
MX2011000671A (es) * 2008-07-18 2011-04-11 Sanofi Aventis Nuevos derivados de triazolo [4,3-a] piridina su procedimiento de preparacion, su uso como medicamentos, composiciones farmaceuticas y nuevo uso particularmente como inhibidores de met.
TWI453207B (zh) * 2008-09-08 2014-09-21 Signal Pharm Llc 胺基三唑并吡啶，其組合物及使用其之治療方法
WO2013049591A2 (en) * 2011-09-29 2013-04-04 Verseon Corporation Dual inhibitor compounds and methods of use thereof

Also Published As

Publication number Publication date
JP2016520113A (ja) 2016-07-11
CA2914040A1 (en) 2014-12-11
WO2014195244A1 (de) 2014-12-11
CN105408331A (zh) 2016-03-16
EP3004095A1 (de) 2016-04-13
US20160108039A1 (en) 2016-04-21

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