HK1222564A1 - 靶向癌症、尤其是前列腺癌的合成性抗體模擬化合物 - Google Patents
靶向癌症、尤其是前列腺癌的合成性抗體模擬化合物Info
- Publication number
- HK1222564A1 HK1222564A1 HK16110785.0A HK16110785A HK1222564A1 HK 1222564 A1 HK1222564 A1 HK 1222564A1 HK 16110785 A HK16110785 A HK 16110785A HK 1222564 A1 HK1222564 A1 HK 1222564A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- syams
- cancer
- synthetic antibody
- antibody mimetic
- mimetic compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2013/039472 WO2014178878A1 (en) | 2013-05-03 | 2013-05-03 | Synthetic antibody mimetic compounds (syams) targeting cancer, especially prostate cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1222564A1 true HK1222564A1 (zh) | 2017-07-07 |
Family
ID=51843839
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16110785.0A HK1222564A1 (zh) | 2013-05-03 | 2016-09-12 | 靶向癌症、尤其是前列腺癌的合成性抗體模擬化合物 |
Country Status (7)
Country | Link |
---|---|
US (3) | US10117943B2 (zh) |
EP (1) | EP2991677B1 (zh) |
JP (1) | JP6473138B2 (zh) |
CN (1) | CN105407920B (zh) |
ES (1) | ES2824026T3 (zh) |
HK (1) | HK1222564A1 (zh) |
WO (1) | WO2014178878A1 (zh) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013070688A1 (en) | 2011-11-11 | 2013-05-16 | Yale University | Reprogramming urokinase into an antibody-recruiting anticancer agent |
WO2013166110A1 (en) | 2012-05-02 | 2013-11-07 | Yale University | Tlr-agonist-conjugated antibody recruiting molecules (tlr_arms) |
WO2017023994A1 (en) | 2015-08-06 | 2017-02-09 | Yale University | Small molecule based antibody-recruiting compounds for cancer treatment |
US10780084B2 (en) | 2016-08-03 | 2020-09-22 | Yale University | Antibody-recruiting molecules for the treatment of cancer |
CN111148527A (zh) * | 2017-07-26 | 2020-05-12 | 克莱奥药品有限公司 | 通用abt化合物及其用途 |
EP3773727A4 (en) * | 2018-04-09 | 2022-05-04 | Yale University | BIFUNCTIONAL SMALL MOLECULES TO TARGETING THE SELECTIVE DEGRADATION OF CIRCULATING PROTEINS |
US11767301B2 (en) | 2018-04-09 | 2023-09-26 | Yale University | Bi-functional molecules to degrade circulating proteins |
US20230083388A1 (en) * | 2018-04-09 | 2023-03-16 | Yale University | Bifunctional Small Molecules to Target the Selective Degradation of Circulating Proteins |
US11065336B2 (en) * | 2018-04-30 | 2021-07-20 | Medimmune Limited | Conjugates for targeting and clearing aggregates |
GB201816554D0 (en) | 2018-10-10 | 2018-11-28 | Centauri Therapeutics Ltd | Novel compounds and therapeutic uses thereof |
US20220023434A1 (en) | 2018-12-19 | 2022-01-27 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional Molecules for Lysosomal Targeting and Related Compositions and Methods |
US20220175819A1 (en) * | 2019-04-19 | 2022-06-09 | Fount Bio, Inc. | Delivery and retention of active agents within the skin |
JP2022551867A (ja) * | 2019-10-10 | 2022-12-14 | イエール ユニバーシティ | 細胞受容体を通じた分子分解剤としての操作された抗体 |
CN113354712B (zh) * | 2021-06-11 | 2023-10-13 | 江苏省原子医学研究所 | 一种酶靶向控制分子内缩合分子探针及其制备方法和应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
MXPA02000961A (es) * | 1999-07-29 | 2003-08-20 | Medarex Inc | Anticuerpos monoclonales humanos para antigeno de membrana especifico de la prostata. |
DE60036388D1 (de) * | 1999-07-30 | 2007-10-25 | Medarex Inc | Therapeutische verbindungen bestehend aus fc rezeptor bindenden wirkstoffen |
US7235641B2 (en) * | 2003-12-22 | 2007-06-26 | Micromet Ag | Bispecific antibodies |
WO2009090268A1 (en) * | 2008-01-17 | 2009-07-23 | Medimmune Limited | Peptide mimetics |
PL2291659T3 (pl) * | 2008-05-13 | 2016-04-29 | Univ Yale | Małe cząsteczki chimerowe do rekrutacji przeciwciał do komórek nowotworowych |
US8852630B2 (en) | 2008-05-13 | 2014-10-07 | Yale University | Chimeric small molecules for the recruitment of antibodies to cancer cells |
HRP20221195T1 (hr) | 2009-03-19 | 2022-12-09 | The Johns Hopkins University | Spojevi koji ciljaju psma i njihova uporaba |
US9181224B2 (en) * | 2009-10-13 | 2015-11-10 | Yale University | Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus |
WO2012068366A2 (en) | 2010-11-18 | 2012-05-24 | Yale University | Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus |
-
2013
- 2013-05-03 CN CN201380077856.2A patent/CN105407920B/zh active Active
- 2013-05-03 EP EP13883761.2A patent/EP2991677B1/en active Active
- 2013-05-03 ES ES13883761T patent/ES2824026T3/es active Active
- 2013-05-03 US US14/888,779 patent/US10117943B2/en active Active
- 2013-05-03 WO PCT/US2013/039472 patent/WO2014178878A1/en active Application Filing
- 2013-05-03 JP JP2016512883A patent/JP6473138B2/ja active Active
-
2016
- 2016-09-12 HK HK16110785.0A patent/HK1222564A1/zh unknown
-
2018
- 2018-11-05 US US16/180,494 patent/US10912836B2/en active Active
-
2020
- 2020-12-15 US US17/122,319 patent/US20220111060A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US10912836B2 (en) | 2021-02-09 |
US20190209696A1 (en) | 2019-07-11 |
US10117943B2 (en) | 2018-11-06 |
CN105407920B (zh) | 2019-12-13 |
JP2016529204A (ja) | 2016-09-23 |
EP2991677A1 (en) | 2016-03-09 |
EP2991677B1 (en) | 2020-07-15 |
US20160082112A1 (en) | 2016-03-24 |
JP6473138B2 (ja) | 2019-02-20 |
CN105407920A (zh) | 2016-03-16 |
ES2824026T3 (es) | 2021-05-11 |
WO2014178878A1 (en) | 2014-11-06 |
US20220111060A1 (en) | 2022-04-14 |
EP2991677A4 (en) | 2016-12-14 |
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