HK1220482A1 - 用於治療癌症幹細胞的反義寡核苷酸 - Google Patents
用於治療癌症幹細胞的反義寡核苷酸Info
- Publication number
- HK1220482A1 HK1220482A1 HK16108389.4A HK16108389A HK1220482A1 HK 1220482 A1 HK1220482 A1 HK 1220482A1 HK 16108389 A HK16108389 A HK 16108389A HK 1220482 A1 HK1220482 A1 HK 1220482A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- treatment
- stem cells
- antisense oligonucleotides
- cancer stem
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/65—MicroRNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361785269P | 2013-03-14 | 2013-03-14 | |
US201361790072P | 2013-03-15 | 2013-03-15 | |
US201461937438P | 2014-02-07 | 2014-02-07 | |
PCT/US2014/029606 WO2014153209A1 (en) | 2013-03-14 | 2014-03-14 | Antisense oligonucletotides for treatment of cancer stem cells |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1220482A1 true HK1220482A1 (zh) | 2017-05-05 |
Family
ID=51581450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16108389.4A HK1220482A1 (zh) | 2013-03-14 | 2016-07-15 | 用於治療癌症幹細胞的反義寡核苷酸 |
Country Status (14)
Country | Link |
---|---|
US (3) | US9862944B2 (zh) |
EP (1) | EP2970970B1 (zh) |
JP (1) | JP6313419B2 (zh) |
CN (2) | CN115518073A (zh) |
BR (1) | BR112015022308A8 (zh) |
CA (1) | CA2906198C (zh) |
CL (1) | CL2015002612A1 (zh) |
DK (1) | DK2970970T3 (zh) |
ES (1) | ES2708650T3 (zh) |
HK (1) | HK1220482A1 (zh) |
HU (1) | HUE042738T2 (zh) |
MX (1) | MX359337B (zh) |
PL (1) | PL2970970T3 (zh) |
WO (1) | WO2014153209A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2970364B1 (en) | 2013-03-14 | 2019-04-24 | Andes Biotechnologies Global, Inc. | Methods for detecting and treating multiple myeloma |
BR112015022308A8 (pt) | 2013-03-14 | 2018-01-23 | Andes Biotechnologies S A | oligonucleotídeos antissenso para o tratamento de células-tronco cancerosas |
KR102145176B1 (ko) * | 2017-11-27 | 2020-08-18 | (주)프로스테믹스 | 올리고뉴클레오티드 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물 |
US20220177852A1 (en) * | 2019-04-11 | 2022-06-09 | Genex Health CO., LTD. | Method for culturing primary cells of gastric cancer and gallbladder and bile duct cancer, and supporting reagents |
CN113893261B (zh) * | 2021-06-22 | 2023-01-13 | 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) | circITGB6-ASO与铂类化疗药物联合使用在制备治疗卵巢癌的药物中的应用 |
Family Cites Families (48)
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US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
US5550111A (en) | 1984-07-11 | 1996-08-27 | Temple University-Of The Commonwealth System Of Higher Education | Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof |
US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
WO1988010264A1 (en) | 1987-06-24 | 1988-12-29 | Howard Florey Institute Of Experimental Physiology | Nucleoside derivatives |
US5194599A (en) | 1988-09-23 | 1993-03-16 | Gilead Sciences, Inc. | Hydrogen phosphonodithioate compositions |
US5399676A (en) | 1989-10-23 | 1995-03-21 | Gilead Sciences | Oligonucleotides with inverted polarity |
US5721218A (en) | 1989-10-23 | 1998-02-24 | Gilead Sciences, Inc. | Oligonucleotides with inverted polarity |
US5587361A (en) | 1991-10-15 | 1996-12-24 | Isis Pharmaceuticals, Inc. | Oligonucleotides having phosphorothioate linkages of high chiral purity |
US5681941A (en) | 1990-01-11 | 1997-10-28 | Isis Pharmaceuticals, Inc. | Substituted purines and oligonucleotide cross-linking |
US5459255A (en) | 1990-01-11 | 1995-10-17 | Isis Pharmaceuticals, Inc. | N-2 substituted purines |
US5321131A (en) | 1990-03-08 | 1994-06-14 | Hybridon, Inc. | Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling |
US5677437A (en) | 1990-07-27 | 1997-10-14 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
US5610289A (en) | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
WO1992002258A1 (en) | 1990-07-27 | 1992-02-20 | Isis Pharmaceuticals, Inc. | Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression |
US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
US5623070A (en) | 1990-07-27 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
US5618704A (en) | 1990-07-27 | 1997-04-08 | Isis Pharmacueticals, Inc. | Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling |
US5608046A (en) | 1990-07-27 | 1997-03-04 | Isis Pharmaceuticals, Inc. | Conjugated 4'-desmethyl nucleoside analog compounds |
ATE131827T1 (de) | 1990-08-03 | 1996-01-15 | Sterling Winthrop Inc | Verbindungen und verfahren zur unterdrückung der genexpression |
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US5672697A (en) | 1991-02-08 | 1997-09-30 | Gilead Sciences, Inc. | Nucleoside 5'-methylene phosphonates |
US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
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US5571799A (en) | 1991-08-12 | 1996-11-05 | Basco, Ltd. | (2'-5') oligoadenylate analogues useful as inhibitors of host-v5.-graft response |
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DE69232816T2 (de) | 1991-11-26 | 2003-06-18 | Isis Pharmaceuticals Inc | Gesteigerte bildung von triple- und doppelhelices aus oligomeren mit modifizierten pyrimidinen |
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US5596091A (en) | 1994-03-18 | 1997-01-21 | The Regents Of The University Of California | Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides |
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US8715645B2 (en) | 1994-05-27 | 2014-05-06 | The Regents Of The University Of Colorado | Viral vectors encoding apoptosis-inducing proteins and methods for making and using the same |
JP4280309B2 (ja) | 1997-06-06 | 2009-06-17 | ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア | Dna免疫刺激配列活性の阻害剤 |
ES2536002T3 (es) * | 2003-05-21 | 2015-05-19 | Andes Biotechnologies S.A. | Marcadores para células pre-cancerígenas y cancerígenas y el método para interferir con la proliferación celular en ellas |
BRPI0617657A2 (pt) | 2005-10-20 | 2016-08-23 | Tokuyama Corp | método para remover ar de um fluido de revestimento contendo ar arrastado, e, aparelho de remoção de ar arrastado em um fluido de revestimento |
JP5342881B2 (ja) | 2006-01-27 | 2013-11-13 | アイシス ファーマシューティカルズ, インコーポレーテッド | 6−修飾された二環式核酸類似体 |
JP2009536222A (ja) | 2006-05-05 | 2009-10-08 | アイシス ファーマシューティカルズ, インコーポレーテッド | Pcsk9の発現を調節するための化合物および方法 |
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CA2706293A1 (en) | 2007-11-20 | 2009-05-28 | Hopitaux Universitaires De Geneve | Methods for identifying, purifying and enriching immature or stem cancer-initiating cells from tumors and use thereof |
HUE026020T2 (en) * | 2009-08-27 | 2016-05-30 | Idera Pharmaceuticals Inc | Preparation for inhibiting gene expression and its uses |
EP2970364B1 (en) | 2013-03-14 | 2019-04-24 | Andes Biotechnologies Global, Inc. | Methods for detecting and treating multiple myeloma |
BR112015022308A8 (pt) | 2013-03-14 | 2018-01-23 | Andes Biotechnologies S A | oligonucleotídeos antissenso para o tratamento de células-tronco cancerosas |
-
2014
- 2014-03-14 BR BR112015022308A patent/BR112015022308A8/pt not_active Application Discontinuation
- 2014-03-14 US US14/775,654 patent/US9862944B2/en active Active
- 2014-03-14 JP JP2016503160A patent/JP6313419B2/ja active Active
- 2014-03-14 CN CN202210729571.3A patent/CN115518073A/zh active Pending
- 2014-03-14 PL PL14770117T patent/PL2970970T3/pl unknown
- 2014-03-14 DK DK14770117.1T patent/DK2970970T3/en active
- 2014-03-14 EP EP14770117.1A patent/EP2970970B1/en active Active
- 2014-03-14 CA CA2906198A patent/CA2906198C/en active Active
- 2014-03-14 HU HUE14770117A patent/HUE042738T2/hu unknown
- 2014-03-14 MX MX2015012063A patent/MX359337B/es active IP Right Grant
- 2014-03-14 WO PCT/US2014/029606 patent/WO2014153209A1/en active Application Filing
- 2014-03-14 ES ES14770117T patent/ES2708650T3/es active Active
- 2014-03-14 CN CN201480026262.3A patent/CN105229150A/zh active Pending
-
2015
- 2015-09-11 CL CL2015002612A patent/CL2015002612A1/es unknown
-
2016
- 2016-07-15 HK HK16108389.4A patent/HK1220482A1/zh not_active IP Right Cessation
-
2017
- 2017-11-29 US US15/826,535 patent/US10457943B2/en active Active
-
2019
- 2019-09-17 US US16/573,983 patent/US11319535B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US11319535B2 (en) | 2022-05-03 |
US10457943B2 (en) | 2019-10-29 |
DK2970970T3 (en) | 2019-02-11 |
US9862944B2 (en) | 2018-01-09 |
JP6313419B2 (ja) | 2018-04-18 |
EP2970970A4 (en) | 2016-10-19 |
ES2708650T3 (es) | 2019-04-10 |
US20200239885A1 (en) | 2020-07-30 |
BR112015022308A8 (pt) | 2018-01-23 |
US20180171335A1 (en) | 2018-06-21 |
WO2014153209A1 (en) | 2014-09-25 |
EP2970970B1 (en) | 2018-12-12 |
WO2014153209A8 (en) | 2015-02-26 |
MX2015012063A (es) | 2016-04-06 |
PL2970970T3 (pl) | 2019-06-28 |
CN115518073A (zh) | 2022-12-27 |
BR112015022308A2 (pt) | 2017-10-10 |
US20160138015A1 (en) | 2016-05-19 |
HUE042738T2 (hu) | 2019-07-29 |
CA2906198A1 (en) | 2014-09-25 |
CL2015002612A1 (es) | 2016-08-26 |
MX359337B (es) | 2018-07-09 |
CN105229150A (zh) | 2016-01-06 |
JP2016519084A (ja) | 2016-06-30 |
EP2970970A1 (en) | 2016-01-20 |
CA2906198C (en) | 2022-11-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20230311 |