HK1217915A1 - 從植物半胱氨酸蛋白酶抑制劑衍生的支架蛋白 - Google Patents

從植物半胱氨酸蛋白酶抑制劑衍生的支架蛋白

Info

Publication number
HK1217915A1
HK1217915A1 HK16105949.3A HK16105949A HK1217915A1 HK 1217915 A1 HK1217915 A1 HK 1217915A1 HK 16105949 A HK16105949 A HK 16105949A HK 1217915 A1 HK1217915 A1 HK 1217915A1
Authority
HK
Hong Kong
Prior art keywords
proteins derived
scaffold proteins
plant cystatins
cystatins
plant
Prior art date
Application number
HK16105949.3A
Other languages
English (en)
Inventor
Michael Mcpherson
Darren Tomlinson
Original Assignee
The Univ Of Leeds
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Univ Of Leeds filed Critical The Univ Of Leeds
Publication of HK1217915A1 publication Critical patent/HK1217915A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1037Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/168Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/415Assays involving biological materials from specific organisms or of a specific nature from plants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
HK16105949.3A 2013-02-14 2016-05-25 從植物半胱氨酸蛋白酶抑制劑衍生的支架蛋白 HK1217915A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1302597.8A GB201302597D0 (en) 2013-02-14 2013-02-14 Novel Synthetic Proteins
PCT/GB2014/050435 WO2014125290A1 (en) 2013-02-14 2014-02-14 Scaffold proteins derived from plant cystatins

Publications (1)

Publication Number Publication Date
HK1217915A1 true HK1217915A1 (zh) 2017-01-27

Family

ID=48048387

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16105949.3A HK1217915A1 (zh) 2013-02-14 2016-05-25 從植物半胱氨酸蛋白酶抑制劑衍生的支架蛋白

Country Status (10)

Country Link
US (2) US9932575B2 (zh)
EP (2) EP3693003A1 (zh)
JP (2) JP6794111B2 (zh)
CN (2) CN113150095A (zh)
AU (2) AU2014217628B2 (zh)
CA (1) CA2900745C (zh)
ES (1) ES2784211T3 (zh)
GB (1) GB201302597D0 (zh)
HK (1) HK1217915A1 (zh)
WO (1) WO2014125290A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201302597D0 (en) * 2013-02-14 2013-04-03 Univ Leeds Novel Synthetic Proteins
GB201407852D0 (en) 2014-05-02 2014-06-18 Iontas Ltd Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules
CN108473987B (zh) 2016-01-08 2024-01-02 马可讯治疗有限公司 具有改变的多样性支架结构域的结合成员
US20210206818A1 (en) 2016-01-22 2021-07-08 Modernatx, Inc. Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof
WO2018211126A1 (en) 2017-05-19 2018-11-22 Philip Morris Products S.A. Diagnostic test for distinguishing the smoking status of a subject
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
US20230331827A1 (en) 2017-07-12 2023-10-19 Maxion Therapeutics Limited Potassium channel inhibitors
GB201711208D0 (en) 2017-07-12 2017-08-23 Iontas Ltd Ion channel inhibitors
JPWO2020175502A1 (ja) 2019-02-27 2021-12-23 国立大学法人 東京医科歯科大学 抗原結合タンパク質と蛍光タンパク質または蛍光標識されるタグタンパク質との融合タンパク質
GB202101299D0 (en) 2020-06-09 2021-03-17 Avacta Life Sciences Ltd Diagnostic polypetides and methods
GB202019607D0 (en) 2020-12-11 2021-01-27 Univ Sheffield Purification of proteins

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
HUP0201009A2 (en) 1999-05-07 2002-07-29 Genentech Inc Treatment of autoimmune diseases with antagonists which bind to b cell surface markers
WO2004113521A1 (en) * 2003-06-18 2004-12-29 Direvo Biotech Ag New biological entities and the use thereof
DE602006016133D1 (de) 2005-06-10 2010-09-23 Medical Res Council London Verwendung von stefin a als gerüstprotein
US20070162998A1 (en) * 2006-01-10 2007-07-12 Kai-Wun Yeh CeCPI: taro cysteine protease inhibitor
AR059448A1 (es) 2006-02-13 2008-04-09 Divergence Inc Polipeptidos quimericos vegetales de union para el reconocimiento molecular universal
US20130305398A1 (en) * 2012-02-16 2013-11-14 Marie Coffin Genes and uses for plant enhacement
GB0807065D0 (en) * 2008-04-18 2008-05-21 Univ Leeds Novel scaffolds
MX2011001368A (es) * 2008-08-05 2011-05-30 Hexima Ltd Sistemas anti-patogenos de plantas.
UY32979A (es) 2009-10-28 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
EP4115911A1 (en) 2010-04-30 2023-01-11 Janssen Biotech, Inc. Stabilized fibronectin domain compositions, methods and uses
CA2809433A1 (en) 2010-08-26 2012-03-01 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
WO2012082069A1 (en) * 2010-12-13 2012-06-21 Agency For Science, Technology And Research Protein aptamers based on unstructured scaffold proteins
GB201302597D0 (en) * 2013-02-14 2013-04-03 Univ Leeds Novel Synthetic Proteins

Also Published As

Publication number Publication date
US9932575B2 (en) 2018-04-03
JP2016510219A (ja) 2016-04-07
AU2017206237A1 (en) 2017-08-10
JP6794111B2 (ja) 2020-12-02
US20160032278A1 (en) 2016-02-04
EP2956156B1 (en) 2020-03-18
CN113150095A (zh) 2021-07-23
CN105120885B (zh) 2021-05-07
GB201302597D0 (en) 2013-04-03
WO2014125290A1 (en) 2014-08-21
ES2784211T3 (es) 2020-09-23
JP6889758B2 (ja) 2021-06-18
EP2956156A1 (en) 2015-12-23
AU2014217628A1 (en) 2015-08-06
US20180245067A1 (en) 2018-08-30
EP3693003A1 (en) 2020-08-12
CA2900745C (en) 2023-01-24
AU2017206237B2 (en) 2019-09-12
CA2900745A1 (en) 2014-08-21
AU2014217628B2 (en) 2017-04-27
CN105120885A (zh) 2015-12-02
JP2019205450A (ja) 2019-12-05
US10844370B2 (en) 2020-11-24

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