HK1217450A1 - 為移植物之器官移植忍耐性的器官及造血細胞合併 - Google Patents

為移植物之器官移植忍耐性的器官及造血細胞合併

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Publication number
HK1217450A1
HK1217450A1 HK16105621.8A HK16105621A HK1217450A1 HK 1217450 A1 HK1217450 A1 HK 1217450A1 HK 16105621 A HK16105621 A HK 16105621A HK 1217450 A1 HK1217450 A1 HK 1217450A1
Authority
HK
Hong Kong
Prior art keywords
grafts
hematopoietic cells
transplantation tolerance
combined organ
organ
Prior art date
Application number
HK16105621.8A
Other languages
English (en)
Inventor
Strober Samuel
Lowsky Robert
Original Assignee
The Board Of Trustees Of The Leland Stanford Junio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Trustees Of The Leland Stanford Junio filed Critical The Board Of Trustees Of The Leland Stanford Junio
Publication of HK1217450A1 publication Critical patent/HK1217450A1/zh

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    • A61K31/365Lactones
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Pulmonology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK16105621.8A 2013-02-26 2016-05-16 為移植物之器官移植忍耐性的器官及造血細胞合併 HK1217450A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361769596P 2013-02-26 2013-02-26
PCT/US2014/015394 WO2014133729A1 (en) 2013-02-26 2014-02-07 Combined organ and hematopoietic cells for transplantation tolerance of grafts

Publications (1)

Publication Number Publication Date
HK1217450A1 true HK1217450A1 (zh) 2017-01-13

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HK16105621.8A HK1217450A1 (zh) 2013-02-26 2016-05-16 為移植物之器官移植忍耐性的器官及造血細胞合併

Country Status (10)

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US (21) US9561253B2 (zh)
EP (2) EP3804735A1 (zh)
JP (1) JP6305443B2 (zh)
KR (2) KR20150132196A (zh)
CN (2) CN113476478A (zh)
AU (2) AU2014221330B2 (zh)
CA (1) CA2902098A1 (zh)
GB (2) GB2526228B (zh)
HK (1) HK1217450A1 (zh)
WO (1) WO2014133729A1 (zh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150132196A (ko) 2013-02-26 2015-11-25 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 이식편의 이식 관용을 위한 합동된 장기와 조혈 세포
CN105431523B (zh) * 2013-03-14 2020-08-21 约翰·霍普金斯大学 纳米级人工抗原呈递细胞
US20190000885A1 (en) * 2015-11-30 2019-01-03 The General Hospital Corporation Treatment with angiogenin to enhance hematopoietic reconstitution
US11273179B2 (en) 2018-03-12 2022-03-15 Medeor Therapeutics, Inc. Methods for treating non-cancerous disorders using hematopoietic cells
US10881692B2 (en) 2018-04-05 2021-01-05 Medeor Therapeutics, Inc. Compositions for establishing mixed chimerism and methods of manufacture thereof
US10842821B2 (en) 2018-04-05 2020-11-24 Medeor Therapeutics, Inc. Cellular compositions derived from prior organ donors and methods of manufacture and use thereof
US20210189344A1 (en) * 2018-08-30 2021-06-24 The Regents Of The University Of California Mobilization and collection of peripheral blood hematopoietic stem cells from deceased donors
US11813376B2 (en) 2018-09-18 2023-11-14 Medeor Therapeutics, Inc. Cellular compositions derived from deceased donors to promote graft tolerance and manufacture and uses thereof
EP3852773A4 (en) * 2018-09-18 2022-06-29 Medeor Therapeutics, Inc. Cellular compositions derived from deceased donors to promote graft tolerance and manufacture and uses thereof
US11435350B2 (en) 2018-09-18 2022-09-06 Medeor Therapeutics, Inc. Methods of analysis of blood from deceased donors
US20200086004A1 (en) * 2018-09-18 2020-03-19 Medeor Therapeutics, Inc. Methods of making cellular compositions derived from deceased donors to promote graft tolerance
WO2020121988A1 (ja) * 2018-12-09 2020-06-18 国立大学法人北海道大学 免疫抑制作用又は免疫寛容誘導作用を評価する方法、及び免疫寛容誘導剤
JP7395174B2 (ja) * 2018-12-09 2023-12-11 国立大学法人北海道大学 免疫抑制作用又は免疫寛容誘導作用を評価する方法、及び免疫寛容誘導剤
US11697799B2 (en) 2019-04-15 2023-07-11 Ossium Health, Inc. System and method for extraction and cryopreservation of bone marrow
WO2021236711A1 (en) * 2020-05-21 2021-11-25 Medeor Therapeutics, Inc. Calcineurin inhibitor to improve cd3+cell survival to thereby facilitate engraftment of donor cd34+ cells in a recipient
EP4181675A4 (en) 2020-07-18 2024-04-24 Ossium Health Inc PERMEATION OF WHOLE VERTEBRAL BODY WITH CRYOPROTECTIVE USING VACUUM-ASSISTED DIFFUSION
CA3191554A1 (en) * 2020-09-30 2022-04-07 Robert LOWSKY Donor hematopoietic cell chimerism and organ and tissue transplantation and autoimmune tolerance
CN116583594A (zh) * 2020-10-14 2023-08-11 奥瑟姆健康公司 用于骨髓的提取和低温保藏的系统和方法
EP4228406A1 (en) 2020-10-14 2023-08-23 Ossium Health, Inc. Systems and methods for extraction and cryopreservation of bone marrow
CN117279650A (zh) * 2020-12-18 2023-12-22 奥瑟姆健康公司 细胞治疗方法
CN112669992B (zh) * 2020-12-30 2024-06-11 中国人民解放军总医院 单倍体造血干细胞移植atg个体化用药量的计算方法
WO2022159824A1 (en) * 2021-01-25 2022-07-28 Ossium Health, Inc. Methods of cell therapies
CN113813454B (zh) * 2021-08-30 2022-09-09 四川大学华西医院 一种采集器官捐献供体血液的方法
CA3228514A1 (en) * 2021-09-07 2023-03-16 David Berglund Method and composition for inducing tolerance

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU734665B2 (en) 1996-05-09 2001-06-21 General Hospital Corporation, The Mixed chimerism and tolerance
WO1999025367A2 (en) 1997-11-14 1999-05-27 The General Hospital Corporation Treatment of hematologic disorders
WO1999039726A1 (en) * 1998-02-04 1999-08-12 The General Hospital Corporation Costimulatory blockade and mixed chimerism in transplantation
WO2000045842A2 (en) 1999-02-04 2000-08-10 The General Hospital Corporation Methods for human allografting
US20020042370A1 (en) * 2000-04-14 2002-04-11 Millennium Pharmaceuticals, Inc. Method of treating graft rejection using inhibitors of CCR2 function
JP2002092615A (ja) 2000-09-20 2002-03-29 Fujitsu Ltd 画像処理装置及び画像形成装置
AU2002220031A1 (en) * 2000-11-14 2002-05-27 The University Of Louisville Research Foundation, Inc. Methods of using cd8+/tcr- facilitating cells (fc) for the engraftment of purified hematopoietic stem cells (hsc)
US20030031652A1 (en) * 2001-04-16 2003-02-13 Bernhard Hering Systems and methods for inducing mixed chimerism
AU2002322857A1 (en) 2001-08-01 2003-02-17 Jewish Hospital Healthcare Services, Inc. Cellular compositions which facilitate engraftment of hematopoietic stem cells while minimizing the risk of gvhd
US20060127399A1 (en) * 2004-09-13 2006-06-15 Defu Zeng Compositions and methods for inducing chimerism in a subject
US7811815B2 (en) 2004-11-15 2010-10-12 The Board Of Trustees Of The Leland Stanford Junior University Therapeutic uses of allogeneic myeloid progenitor cells
EP1904101A4 (en) * 2005-06-08 2011-06-15 Univ Duke ANTI-CD19 ANTIBODY THERAPY FOR TRANSPLANTATION
US8916147B2 (en) * 2005-08-24 2014-12-23 Yeda Research and Devolpment Co. Ltd. Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance
WO2007033221A2 (en) * 2005-09-13 2007-03-22 The General Hospital Corporation Methods and compositions for inhibition of immune responses
US8632768B2 (en) * 2008-05-30 2014-01-21 University Of Louisville Research Foundation, Inc. Human facilitating cells
CA2782803C (en) * 2009-12-02 2020-09-01 The Board Of Trustees Of The Leland Stanford Junior University Biomarkers for determining an allograft tolerant phenotype
US20110137375A1 (en) 2009-12-03 2011-06-09 Mcbride Keith System and method for detection of inversion and eversion of the foot using a multi-chamber insole
US20120177621A1 (en) * 2011-01-10 2012-07-12 Samuel Strober Enhancement of Allogeneic Hematopoietic Stem Cell Transplantation
JP2015508101A (ja) * 2012-02-21 2015-03-16 バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated Cd34+細胞を含む薬学的組成物
KR20150132196A (ko) 2013-02-26 2015-11-25 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 이식편의 이식 관용을 위한 합동된 장기와 조혈 세포

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