HK1214500A1 - 核磁共振診斷劑以及使用所述核磁共振診斷劑來檢測或診斷對象中細胞、組織或器官狀態的方法 - Google Patents

核磁共振診斷劑以及使用所述核磁共振診斷劑來檢測或診斷對象中細胞、組織或器官狀態的方法

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Publication number
HK1214500A1
HK1214500A1 HK16102342.3A HK16102342A HK1214500A1 HK 1214500 A1 HK1214500 A1 HK 1214500A1 HK 16102342 A HK16102342 A HK 16102342A HK 1214500 A1 HK1214500 A1 HK 1214500A1
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HK
Hong Kong
Prior art keywords
organ
tissue
subject
cell
detecting
Prior art date
Application number
HK16102342.3A
Other languages
English (en)
Inventor
Tetsuya Yoneda
Shigeru Nishizawa
Junkoh Yamamoto
Tohru Tanaka
Hidenori Itoh
Original Assignee
Nat Univ Corp Kumamoto Univ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Nat Univ Corp Kumamoto Univ filed Critical Nat Univ Corp Kumamoto Univ
Publication of HK1214500A1 publication Critical patent/HK1214500A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
    • A61K49/1836—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule the small organic molecule being a carboxylic acid having less than 8 carbon atoms in the main chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Signal Processing (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
HK16102342.3A 2012-12-11 2016-03-01 核磁共振診斷劑以及使用所述核磁共振診斷劑來檢測或診斷對象中細胞、組織或器官狀態的方法 HK1214500A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012270844 2012-12-11
PCT/JP2013/082974 WO2014092051A1 (ja) 2012-12-11 2013-12-09 核磁気共鳴診断剤、及び、それを用いた、対象内の細胞、組織又は臓器の状態を検出又は診断する方法

Publications (1)

Publication Number Publication Date
HK1214500A1 true HK1214500A1 (zh) 2016-07-29

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HK15111717.2A HK1210943A1 (zh) 2012-12-11 2015-11-27 核磁共振診斷劑以及使用所述核磁共振診斷劑來檢測或診斷對象中細胞、組織或器官狀態的方法
HK16102342.3A HK1214500A1 (zh) 2012-12-11 2016-03-01 核磁共振診斷劑以及使用所述核磁共振診斷劑來檢測或診斷對象中細胞、組織或器官狀態的方法

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Country Status (6)

Country Link
US (1) US11633505B2 (zh)
EP (1) EP2932983B1 (zh)
JP (1) JP5980953B2 (zh)
CN (1) CN104981255B (zh)
HK (2) HK1210943A1 (zh)
WO (1) WO2014092051A1 (zh)

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JP5980953B2 (ja) 2012-12-11 2016-08-31 国立大学法人 熊本大学 核磁気共鳴診断剤、及び、それを用いた、対象内の細胞、組織又は臓器の状態を検出又は診断する方法
US9494503B2 (en) 2013-11-06 2016-11-15 Aspect Imaging Ltd. Inline rheology/viscosity, density, and flow rate measurement
CN104635186A (zh) * 2014-12-26 2015-05-20 苏州露宇电子科技有限公司 移动式核磁共振分析仪驱动机构
US10670574B2 (en) 2015-01-19 2020-06-02 Aspect International (2015) Private Limited NMR-based systems for crude oil enhancement and methods thereof
CN106053299B (zh) 2015-04-12 2020-10-30 艾斯拜克特Ai有限公司 非圆形横截面管道中的流体的nmr成像
CN106324010A (zh) 2015-07-02 2017-01-11 艾斯拜克特Ai有限公司 使用mr设备对在管道中流动的流体的分析
KR101807392B1 (ko) 2016-03-10 2017-12-12 연세대학교 산학협력단 자기공명 이미지에서 조영 증강이 없는 뇌실벽에서 수술 중 광감작제-유도 형광에 의한 신경교종 탐지
US10655996B2 (en) 2016-04-12 2020-05-19 Aspect Imaging Ltd. System and method for measuring velocity profiles
KR101864992B1 (ko) * 2017-03-09 2018-07-04 국립암센터 Mri 노이즈 제거용 조성물 및 이를 이용한 패드

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JP5034032B2 (ja) 2004-09-29 2012-09-26 Ｓｂｉファーマ株式会社 腫瘍診断剤
WO2006096492A2 (en) * 2005-03-04 2006-09-14 Dusa Pharmaceuticals, Inc. Compositions and methods for reducing photosensitivity associated with photodynamic therapy
JP5098051B2 (ja) 2007-04-05 2012-12-12 Ｓｂｉファーマ株式会社 ミトコンドリア障害脳疾患治療剤及び診断剤
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JP5295652B2 (ja) * 2008-06-16 2013-09-18 Ｓｂｉファーマ株式会社 光障害の軽減剤
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WO2010090673A1 (en) * 2009-01-20 2010-08-12 The Trustees Of Dartmouth College Method and apparatus for depth-resolved fluorescence, chromophore, and oximetry imaging for lesion identification during surgery
JP2011026221A (ja) 2009-07-22 2011-02-10 Sbi Alapromo Co Ltd プロトポルフィリンｉｘ細胞内集積増強組成物
JP5980953B2 (ja) 2012-12-11 2016-08-31 国立大学法人 熊本大学 核磁気共鳴診断剤、及び、それを用いた、対象内の細胞、組織又は臓器の状態を検出又は診断する方法

Also Published As

Publication number Publication date
US20150320888A1 (en) 2015-11-12
EP2932983A1 (en) 2015-10-21
JP5980953B2 (ja) 2016-08-31
US11633505B2 (en) 2023-04-25
CN104981255B (zh) 2018-11-30
EP2932983B1 (en) 2018-09-12
EP2932983A4 (en) 2016-08-17
CN104981255A (zh) 2015-10-14
HK1210943A1 (zh) 2016-05-13
JPWO2014092051A1 (ja) 2017-01-12
WO2014092051A1 (ja) 2014-06-19

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