HK1212219A1 - 177-lu labeled peptide for site-specific upar-targeting upar 177-lu - Google Patents
177-lu labeled peptide for site-specific upar-targeting upar 177-luInfo
- Publication number
- HK1212219A1 HK1212219A1 HK16100118.9A HK16100118A HK1212219A1 HK 1212219 A1 HK1212219 A1 HK 1212219A1 HK 16100118 A HK16100118 A HK 16100118A HK 1212219 A1 HK1212219 A1 HK 1212219A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- upar
- site
- targeting
- specific
- labeled peptide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201200321 | 2012-05-08 | ||
PCT/DK2013/050126 WO2013167130A1 (en) | 2012-05-08 | 2013-05-03 | 177-Lu LABELED PEPTIDE FOR SITE-SPECIFIC uPAR-TARGETING |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1212219A1 true HK1212219A1 (en) | 2016-06-10 |
Family
ID=49550163
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16100118.9A HK1212219A1 (en) | 2012-05-08 | 2016-01-07 | 177-lu labeled peptide for site-specific upar-targeting upar 177-lu |
Country Status (7)
Country | Link |
---|---|
US (2) | US10994032B2 (de) |
EP (1) | EP2846826B1 (de) |
JP (2) | JP2015532636A (de) |
CN (1) | CN104768573B (de) |
CA (1) | CA2905172C (de) |
HK (1) | HK1212219A1 (de) |
WO (1) | WO2013167130A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10994032B2 (en) * | 2012-05-08 | 2021-05-04 | Trt Innovations Aps | 177-Lu labeled peptide for site-specific uPAR-targeting |
EP2928505B1 (de) * | 2012-12-03 | 2019-08-28 | Curasight APS | Positronenemittierende radionukleidmarkierte peptide für humane upar-pet-bildgebung |
EP3733215A1 (de) | 2014-09-17 | 2020-11-04 | Fluoguide A/S | Gegen upar gerichtetes peptid zur peroperativen optischen bildgebung von invasivem krebs |
WO2017192598A1 (en) * | 2016-05-02 | 2017-11-09 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Pre-targeting strategies for molecular imaging and/or radioimmunotherapy |
US11951168B2 (en) * | 2016-08-19 | 2024-04-09 | Perseus Proteomics Inc. | Composition containing buffer |
WO2018091058A1 (en) * | 2016-11-17 | 2018-05-24 | Rigshospitalet | 177-lu labeled active site inhibited factor vii |
JP7487110B2 (ja) * | 2018-04-05 | 2024-05-20 | フュージョン ファーマシューティカルズ インコーポレイテッド | Hsp90標的化コンジュゲート及びその製剤 |
US10596278B2 (en) | 2018-07-25 | 2020-03-24 | Advanced Accelerator Applications (Italy) S.R.L. | Stable, concentrated radionuclide complex solutions |
US10596276B2 (en) | 2018-07-25 | 2020-03-24 | Advanced Accelerator Applications (Italy) S.R.L. | Stable, concentrated radionuclide complex solutions |
KR20230173075A (ko) | 2020-12-01 | 2023-12-26 | 큐라사이트 에이/에스 | 우로키나아제 플라스미노겐 활성제 수용체 (Urokinase Plasminogen Activator Receptor) 표적화된 방사성 표지된 펩티드 접합체들 |
WO2023173074A2 (en) * | 2022-03-10 | 2023-09-14 | The Research Foundation For The State University Of New York | Immunostimulant-cytotoxic conjugate composition and methods for cancer treatment |
CN114874308B (zh) * | 2022-05-26 | 2023-02-17 | 苏州大学 | 一种核素标记的抑制肽及其制备方法和应用 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4444690A (en) | 1982-02-25 | 1984-04-24 | University Patents, Inc. | Technetium chelates |
US4479930A (en) | 1982-07-26 | 1984-10-30 | Trustees Of The University Of Massachusetts | Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product |
US5120526A (en) | 1985-01-14 | 1992-06-09 | Neorx Corporation | Method of producing metal radionuclide labeled proteins for diagnosis and therapy |
US4861869A (en) | 1986-05-29 | 1989-08-29 | Mallinckrodt, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
US4965392A (en) | 1987-03-26 | 1990-10-23 | Neorx Corporation | Chelating compounds for metal-radionuclide labeled proteins |
US5175257A (en) | 1989-12-29 | 1992-12-29 | Neorx Corporation | Radiolabeled proteins for diagnostic or therapeutic use |
US5310536A (en) | 1992-02-06 | 1994-05-10 | Mallinckrodt Medical, Inc. | Ligands for improving metal chelate formation kinetics |
US5830431A (en) | 1995-06-07 | 1998-11-03 | Mallinckrodt Medical, Inc. | Radiolabeled peptide compositions for site-specific targeting |
US5942492A (en) | 1996-11-12 | 1999-08-24 | Angstrom Pharmaceuticals, Inc. | Cyclic peptides that bind to urokinase-type plasminogen activator receptor |
US6277818B1 (en) * | 1998-10-29 | 2001-08-21 | Angstrom Pharmaceuticals, Inc. | Cyclic peptide ligands that target urokinase plasminogen activator receptor |
AR020101A1 (es) * | 1998-07-01 | 2002-04-10 | Cancerforskingsfonden Af 1989 | Un antagonista peptido del receptor de uroquinasa humana, composicion farmaceutica que lo contiene, su uso para la manufactura de un medicamento y metodopara seleccionar un antagonista peptido adecuado. |
AU780730B2 (en) | 1999-10-01 | 2005-04-14 | Angstrom Pharmaceuticals, Inc. | Diagnostic probes and therapeutics targeting uPA and uPAR |
CN101065152A (zh) * | 2004-09-29 | 2007-10-31 | 通用电气医疗集团股份有限公司 | 靶向尿激酶纤溶酶原激活物受体的造影剂 |
US20070190068A1 (en) * | 2005-10-10 | 2007-08-16 | Richard Hart | uPAR-binding molecule-drug conjugates and uses thereof |
WO2007134274A2 (en) | 2006-05-12 | 2007-11-22 | Attenuon, Llc | Antibodies to urokinase- type plasminogen activator receptor(upar)bind cancer stem cells: use in diagnosis and therapy |
HUE044625T2 (hu) * | 2011-08-31 | 2019-11-28 | Somscan Aps | PET nyomjelzõ neuroendokrin tumorok képalkotásához |
US10994032B2 (en) * | 2012-05-08 | 2021-05-04 | Trt Innovations Aps | 177-Lu labeled peptide for site-specific uPAR-targeting |
EP2928505B1 (de) * | 2012-12-03 | 2019-08-28 | Curasight APS | Positronenemittierende radionukleidmarkierte peptide für humane upar-pet-bildgebung |
EP3733215A1 (de) * | 2014-09-17 | 2020-11-04 | Fluoguide A/S | Gegen upar gerichtetes peptid zur peroperativen optischen bildgebung von invasivem krebs |
-
2013
- 2013-05-03 US US14/399,820 patent/US10994032B2/en active Active
- 2013-05-03 WO PCT/DK2013/050126 patent/WO2013167130A1/en active Application Filing
- 2013-05-03 EP EP13788361.7A patent/EP2846826B1/de active Active
- 2013-05-03 CA CA2905172A patent/CA2905172C/en active Active
- 2013-05-03 CN CN201380032450.2A patent/CN104768573B/zh active Active
- 2013-05-03 JP JP2015510647A patent/JP2015532636A/ja active Pending
-
2016
- 2016-01-07 HK HK16100118.9A patent/HK1212219A1/xx unknown
-
2019
- 2019-01-17 JP JP2019005811A patent/JP6814234B2/ja active Active
-
2021
- 2021-01-07 US US17/144,067 patent/US20210236666A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP6814234B2 (ja) | 2021-01-13 |
CA2905172A1 (en) | 2013-11-14 |
EP2846826A4 (de) | 2015-12-23 |
WO2013167130A1 (en) | 2013-11-14 |
JP2019077712A (ja) | 2019-05-23 |
CA2905172C (en) | 2021-07-20 |
US20150132219A1 (en) | 2015-05-14 |
CN104768573B (zh) | 2017-08-29 |
CN104768573A (zh) | 2015-07-08 |
US20210236666A1 (en) | 2021-08-05 |
EP2846826B1 (de) | 2018-07-25 |
EP2846826A1 (de) | 2015-03-18 |
US10994032B2 (en) | 2021-05-04 |
JP2015532636A (ja) | 2015-11-12 |
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