HK1206995A1 - 用於提高 活性的方法 - Google Patents

用於提高 活性的方法

Info

Publication number
HK1206995A1
HK1206995A1 HK15107706.3A HK15107706A HK1206995A1 HK 1206995 A1 HK1206995 A1 HK 1206995A1 HK 15107706 A HK15107706 A HK 15107706A HK 1206995 A1 HK1206995 A1 HK 1206995A1
Authority
HK
Hong Kong
Prior art keywords
cftr
methods
increasing
activity
cftr activity
Prior art date
Application number
HK15107706.3A
Other languages
English (en)
Inventor
Steven M Rowe
Mark Dransfield
Original Assignee
Uab Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uab Research Foundation filed Critical Uab Research Foundation
Publication of HK1206995A1 publication Critical patent/HK1206995A1/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
HK15107706.3A 2012-04-06 2015-08-10 用於提高 活性的方法 HK1206995A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261621043P 2012-04-06 2012-04-06
PCT/US2013/032268 WO2013151758A2 (en) 2012-04-06 2013-03-15 Methods for increasing cftr activity

Publications (1)

Publication Number Publication Date
HK1206995A1 true HK1206995A1 (zh) 2016-01-22

Family

ID=49301152

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15107706.3A HK1206995A1 (zh) 2012-04-06 2015-08-10 用於提高 活性的方法

Country Status (8)

Country Link
US (2) US20150065539A1 (zh)
EP (1) EP2833885A4 (zh)
JP (1) JP6525203B2 (zh)
CN (1) CN104619321A (zh)
AU (2) AU2013243857A1 (zh)
CA (1) CA2869257A1 (zh)
HK (1) HK1206995A1 (zh)
WO (1) WO2013151758A2 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT1993360T (lt) 2005-12-28 2017-06-12 Vertex Pharmaceuticals Incorporated N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma
AU2015330923B2 (en) 2014-10-07 2020-03-12 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH690023A5 (de) * 1996-02-02 2000-03-31 Medichemie Ag Mittel zur Behandlung krankhafter Zellveränderungen der Nasenschleimhaut.
US20040266883A1 (en) * 1999-10-27 2004-12-30 Yale University Conductance of improperly folded proteins through the secretory pathway and related methods for treating disease
US7541466B2 (en) * 2003-12-23 2009-06-02 Genzyme Corporation Tetrahydroisoquinoline derivatives for treating protein trafficking diseases
JP5575768B2 (ja) * 2008-08-13 2014-08-20 バーテックス ファーマシューティカルズ インコーポレイテッド 薬学的組成物およびその投与
US20100256184A1 (en) * 2008-08-13 2010-10-07 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
JP2013504554A (ja) * 2009-09-12 2013-02-07 レキット ベンキサー エルエルシー ムチン分泌を抑制するためのグアイフェネシンの使用
EP2547335A4 (en) * 2010-03-15 2014-04-16 Univ Virginia Commonwealth AEROSOLIC DAPSONE AS THERAPY AGAINST INFLAMMATION OF THE RESPIRATORY SYSTEM AND ANOMALY OF MUCOCILIARY TRANSPORT
CA2792207A1 (en) * 2010-03-19 2011-09-22 Vertex Pharmaceuticals Incorporated Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
MX349159B (es) * 2011-05-18 2017-07-14 Concert Pharmaceuticals Inc Derivados deuterados de ivacaftor.

Also Published As

Publication number Publication date
CN104619321A (zh) 2015-05-13
US10300052B2 (en) 2019-05-28
AU2013243857A1 (en) 2014-10-16
US20150065539A1 (en) 2015-03-05
JP2015521157A (ja) 2015-07-27
JP6525203B2 (ja) 2019-06-05
AU2018200192B2 (en) 2019-06-06
EP2833885A2 (en) 2015-02-11
EP2833885A4 (en) 2015-12-16
WO2013151758A2 (en) 2013-10-10
CA2869257A1 (en) 2013-10-10
AU2018200192A1 (en) 2018-02-01
US20170266177A1 (en) 2017-09-21
AU2018200192B9 (en) 2019-07-25

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