HK1206425A1 - Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration - Google Patents

Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration Download PDF

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Publication number
HK1206425A1
HK1206425A1 HK15106894.7A HK15106894A HK1206425A1 HK 1206425 A1 HK1206425 A1 HK 1206425A1 HK 15106894 A HK15106894 A HK 15106894A HK 1206425 A1 HK1206425 A1 HK 1206425A1
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HK
Hong Kong
Prior art keywords
brain injury
brain
biomarkers
neurodegeneration
citrullinated
Prior art date
Application number
HK15106894.7A
Other languages
English (en)
Chinese (zh)
Inventor
Jennifer E. Van Eyk
Allen Dale EVERETT
Zhicheng JIN
Original Assignee
The Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by The Johns Hopkins University filed Critical The Johns Hopkins University
Publication of HK1206425A1 publication Critical patent/HK1206425A1/xx

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/0077—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction specific reactions other than fragmentation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/18—Post-translational modifications [PTMs] in chemical analysis of biological material citrullination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
HK15106894.7A 2012-03-13 2013-03-13 Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration HK1206425A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261610034P 2012-03-13 2012-03-13
US61/610,034 2012-03-13
PCT/US2013/031012 WO2013138509A1 (en) 2012-03-13 2013-03-13 Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration

Publications (1)

Publication Number Publication Date
HK1206425A1 true HK1206425A1 (en) 2016-01-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
HK15106894.7A HK1206425A1 (en) 2012-03-13 2013-03-13 Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration

Country Status (5)

Country Link
US (4) US9709573B2 (https=)
EP (1) EP2825893A4 (https=)
JP (1) JP6392202B2 (https=)
HK (1) HK1206425A1 (https=)
WO (1) WO2013138509A1 (https=)

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Also Published As

Publication number Publication date
US20150031048A1 (en) 2015-01-29
US9709573B2 (en) 2017-07-18
JP6392202B2 (ja) 2018-09-19
US12007395B2 (en) 2024-06-11
WO2013138509A1 (en) 2013-09-19
EP2825893A1 (en) 2015-01-21
JP2015513370A (ja) 2015-05-11
US20190310265A1 (en) 2019-10-10
US10365288B2 (en) 2019-07-30
US20250085292A1 (en) 2025-03-13
US20170370943A1 (en) 2017-12-28
EP2825893A4 (en) 2016-03-16

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