HK1205156A1 - Cyclodextrin-based polymers for therapeutic delivery - Google Patents

Cyclodextrin-based polymers for therapeutic delivery

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Publication number
HK1205156A1
HK1205156A1 HK15105451.4A HK15105451A HK1205156A1 HK 1205156 A1 HK1205156 A1 HK 1205156A1 HK 15105451 A HK15105451 A HK 15105451A HK 1205156 A1 HK1205156 A1 HK 1205156A1
Authority
HK
Hong Kong
Prior art keywords
cyclodextrin
based polymers
therapeutic delivery
therapeutic
delivery
Prior art date
Application number
HK15105451.4A
Other languages
English (en)
Chinese (zh)
Inventor
Scott Eliasof
Original Assignee
Cerulean Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerulean Pharma Inc filed Critical Cerulean Pharma Inc
Publication of HK1205156A1 publication Critical patent/HK1205156A1/xx

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    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
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    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • C08B37/0009Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/16Cyclodextrin; Derivatives thereof

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Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11605043B2 (en) 2011-02-22 2023-03-14 Theatro Labs, Inc. Configuring, deploying, and operating an application for buy-online-pickup-in-store (BOPIS) processes, actions and analytics
US10204524B2 (en) 2011-02-22 2019-02-12 Theatro Labs, Inc. Observation platform for training, monitoring and mining structured communications
US11636420B2 (en) 2011-02-22 2023-04-25 Theatro Labs, Inc. Configuring, deploying, and operating applications for structured communications within observation platforms
US10069781B2 (en) 2015-09-29 2018-09-04 Theatro Labs, Inc. Observation platform using structured communications with external devices and systems
KR101659649B1 (ko) 2011-02-22 2016-09-23 디아트로 랩스, 인크. 구조화된 통신을 이용하기 위한 관측 플랫폼
US10375133B2 (en) 2011-02-22 2019-08-06 Theatro Labs, Inc. Content distribution and data aggregation for scalability of observation platforms
US9542695B2 (en) 2011-02-22 2017-01-10 Theatro Labs, Inc. Observation platform for performing structured communications
US10699313B2 (en) 2011-02-22 2020-06-30 Theatro Labs, Inc. Observation platform for performing structured communications
US11599843B2 (en) 2011-02-22 2023-03-07 Theatro Labs, Inc. Configuring , deploying, and operating an application for structured communications for emergency response and tracking
US9407543B2 (en) 2011-02-22 2016-08-02 Theatrolabs, Inc. Observation platform for using structured communications with cloud computing
US10134001B2 (en) 2011-02-22 2018-11-20 Theatro Labs, Inc. Observation platform using structured communications for gathering and reporting employee performance information
US9602625B2 (en) 2011-02-22 2017-03-21 Theatrolabs, Inc. Mediating a communication in an observation platform
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
EP2991634A1 (fr) 2013-04-30 2016-03-09 Otitopic Inc. Formulations de poudre sèche et procédés d'utilisation
CN104961786B (zh) * 2015-06-05 2018-09-25 苏州大学 基于吉西他滨结构的前体药物及其应用
CN105560635A (zh) * 2015-09-17 2016-05-11 张名静 一种治疗黑色棘皮病的中药
US11110172B2 (en) 2016-04-08 2021-09-07 Imam Abdulrahman Bin Faisal University Method for treating multiloculated hydrocephalus by administering an anti-IL6 receptor antibody
WO2018112397A1 (fr) * 2016-12-16 2018-06-21 Bluelink Pharmaceuticals, Inc. Traitement du cancer
PT109941B (pt) 2017-03-02 2021-02-09 Hovione Farmaciência, S.A. Conjugados de boro multifuncionais com uma estrutura tripodal, composições farmacêuticas e processos de preparação dos mesmos
CN111315363B (zh) 2017-09-22 2022-10-11 奥迪托皮克股份有限公司 含有硬脂酸镁的干粉组合物
US10786456B2 (en) 2017-09-22 2020-09-29 Otitopic Inc. Inhaled aspirin and magnesium to treat inflammation
CN108084295A (zh) * 2017-10-09 2018-05-29 浙江大学 一种环糊精基一氧化氮供体及其制备方法
AU2019205542A1 (en) * 2018-01-08 2020-07-16 Regeneron Pharmaceuticals, Inc. Steroids and antibody-conjugates thereof
JP6939606B2 (ja) 2018-01-29 2021-09-22 トヨタ自動車株式会社 ハイブリッド車両
CN114423461A (zh) * 2019-07-09 2022-04-29 杰尼西斯制药有限公司 组合
CA3185968A1 (fr) 2020-07-13 2022-01-20 Tony Lahoutte Fragment d'anticorps contre folr1
CN115109258A (zh) * 2021-03-19 2022-09-27 江西中医药大学 7-乙基-10-羟基喜树碱聚合物、制备方法及其应用
WO2023203135A1 (fr) 2022-04-22 2023-10-26 Precirix N.V. Anticorps radiomarqué amélioré
CN114748642A (zh) * 2022-04-29 2022-07-15 江西本草天工科技有限责任公司 一种四价铂药-聚合物偶联物纳米胶束及制备方法和应用
WO2023213801A1 (fr) 2022-05-02 2023-11-09 Precirix N.V. Pré-ciblage
CN116120333B (zh) * 2023-02-17 2024-01-26 沈阳药科大学 一种鬼臼毒素纳米前药及其制备方法与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6509323B1 (en) * 1998-07-01 2003-01-21 California Institute Of Technology Linear cyclodextrin copolymers
US7091192B1 (en) * 1998-07-01 2006-08-15 California Institute Of Technology Linear cyclodextrin copolymers
CA2818071C (fr) * 2002-09-06 2015-08-18 Cerulean Pharma Inc. Composes cycliques de cyclodextrine modifies comptant exactement deux fractions hydroxyle substituees par un acide amine aux fins d'une administration de produit therapeutique
EP2277551B1 (fr) * 2002-09-06 2013-05-08 Cerulean Pharma Inc. Polymeres a base de cyclodextrine pour l'administration de medicament lies par liaison covalente
EP2170054A4 (fr) * 2007-06-28 2012-08-08 Capsutech Ltd Ciblage de conjugues renfermant des agents actifs encapsules dans des polymeres contenant de la cyclodextrine
CN102781237A (zh) * 2009-11-23 2012-11-14 天蓝制药公司 用于传递治疗剂的基于环糊精的聚合物
WO2011089216A1 (fr) * 2010-01-22 2011-07-28 Ascendis Pharma As Lieurs de précurseurs à base de dipeptides pour des médicaments contenant des amines aliphatiques
AU2011255647A1 (en) * 2010-05-18 2012-11-15 Cerulean Pharma Inc. Compositions and methods for treatment of autoimmune and other diseases

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