HK1204939A1 - '- '- '- 包含 ’-氟- -二甲基- -苯基- ’， ’-二氫- -螺 環己烷- ’-吡喃並 吲哚 -胺和奧昔康類化合物的藥物組合物 - Google Patents

'- '- '- 包含 ’-氟- -二甲基- -苯基- ’， ’-二氫- -螺 環己烷- ’-吡喃並 吲哚 -胺和奧昔康類化合物的藥物組合物

Info

Publication number
HK1204939A1
HK1204939A1 HK15105570.0A HK15105570A HK1204939A1 HK 1204939 A1 HK1204939 A1 HK 1204939A1 HK 15105570 A HK15105570 A HK 15105570A HK 1204939 A1 HK1204939 A1 HK 1204939A1
Authority
HK
Hong Kong
Prior art keywords
oxicam
pyrano
indol
spiro
dihydro
Prior art date
Application number
HK15105570.0A
Other languages
English (en)
Inventor
Stefanie Frosch
Klaus Linz
Klaus Schiene
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of HK1204939A1 publication Critical patent/HK1204939A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK15105570.0A 2012-05-18 2015-06-11 '- '- '- 包含 ’-氟- -二甲基- -苯基- ’， ’-二氫- -螺 環己烷- ’-吡喃並 吲哚 -胺和奧昔康類化合物的藥物組合物 HK1204939A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12003896 2012-05-18
PCT/EP2013/001469 WO2013170970A1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and an oxicam

Publications (1)

Publication Number Publication Date
HK1204939A1 true HK1204939A1 (zh) 2015-12-11

Family

ID=48470899

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15105570.0A HK1204939A1 (zh) 2012-05-18 2015-06-11 '- '- '- 包含 ’-氟- -二甲基- -苯基- ’， ’-二氫- -螺 環己烷- ’-吡喃並 吲哚 -胺和奧昔康類化合物的藥物組合物

Country Status (23)

Country Link
US (1) US9308196B2 (zh)
EP (1) EP2849746B1 (zh)
JP (1) JP6116677B2 (zh)
CN (2) CN108451956A (zh)
AU (1) AU2013262076B2 (zh)
BR (1) BR112014028569A2 (zh)
CA (1) CA2873863A1 (zh)
CY (1) CY1119824T1 (zh)
DK (1) DK2849746T3 (zh)
EA (1) EA026719B1 (zh)
ES (1) ES2659948T3 (zh)
HK (1) HK1204939A1 (zh)
HR (1) HRP20171843T1 (zh)
HU (1) HUE035122T2 (zh)
IL (1) IL235652B (zh)
LT (1) LT2849746T (zh)
MX (1) MX354685B (zh)
NO (1) NO2849746T3 (zh)
PL (1) PL2849746T3 (zh)
PT (1) PT2849746T (zh)
RS (1) RS56830B1 (zh)
SI (1) SI2849746T1 (zh)
WO (1) WO2013170970A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3247352T3 (da) 2015-01-23 2020-09-07 Gruenenthal Gmbh Cebranopadol til behandling af smerter hos individer med forringet lever- og/eller forringet nyrefunktion

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US4389393A (en) 1982-03-26 1983-06-21 Forest Laboratories, Inc. Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
US4612008A (en) 1983-05-11 1986-09-16 Alza Corporation Osmotic device with dual thermodynamic activity
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ES2358763T3 (es) * 2006-04-28 2011-05-13 Grünenthal GmbH Combinación farmacéutica que comprende 3-(3-dimetilamino-1-etil-2-metilpropil)fenol y un nsaid.
CN101147735A (zh) 2006-09-19 2008-03-26 沈阳华泰药物研究有限公司 注射用药物组合物及其药盒
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DE102006056458A1 (de) 2006-11-28 2008-05-29 Grünenthal GmbH Arzneimittelzubereitung von Tramadol und Acetaminophen
CN100560061C (zh) 2008-06-20 2009-11-18 海南锦瑞制药股份有限公司 一种氯诺昔康冻干粉针剂及其制备方法
PE20110305A1 (es) * 2008-09-05 2011-06-15 Gruenenthal Chemie Combinacion farmaceutica que contiene el 6-dimetilaminometil-1-(3-metoxi-fenil)-ciclohexano-1,3-diol y un nsaid
KR101851120B1 (ko) * 2008-09-05 2018-04-23 그뤼넨탈 게엠베하 3-（3-디메틸아미노-1-에틸-2-메틸-프로필）-페놀과 항간질제의 약제학적 병용물
WO2012016695A2 (en) * 2010-08-04 2012-02-09 Grünenthal GmbH Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cylohexane-1,1'-pyrano[3,4,b]indol]-4-amine
BR112013002734A2 (pt) * 2010-08-04 2016-06-07 Gruenenthal Gmbh uso de agente farmacologicamente ativo e forma de dosagem farmacêutica
RU2589830C2 (ru) * 2010-08-04 2016-07-10 Грюненталь Гмбх ЛЕКАРСТВЕННАЯ ДОЗИРОВАННАЯ ФОРМА, КОТОРАЯ СОДЕРЖИТ 6'-ФТОР-(N-МЕТИЛ- ИЛИ N, N-ДИМЕТИЛ-)-4-ФЕНИЛ-4', 9'-ДИГИДРО-3'Н-СПИРО[ЦИКЛОГЕКСАН-1, 1'-ПИРАНО[3, 4, b]ИНДОЛ]-4-АМИН

Also Published As

Publication number Publication date
NO2849746T3 (zh) 2018-04-14
EP2849746B1 (en) 2017-11-15
EP2849746A1 (en) 2015-03-25
PL2849746T3 (pl) 2018-04-30
MX354685B (es) 2018-03-15
EA026719B1 (ru) 2017-05-31
HRP20171843T1 (hr) 2018-01-12
PT2849746T (pt) 2018-02-22
JP6116677B2 (ja) 2017-04-19
CN108451956A (zh) 2018-08-28
ES2659948T3 (es) 2018-03-20
SI2849746T1 (en) 2018-02-28
CN104302288A (zh) 2015-01-21
EA201401265A1 (ru) 2015-05-29
US20130310371A1 (en) 2013-11-21
BR112014028569A2 (pt) 2017-06-27
US9308196B2 (en) 2016-04-12
WO2013170970A1 (en) 2013-11-21
CY1119824T1 (el) 2018-06-27
AU2013262076B2 (en) 2017-10-26
MX2014012862A (es) 2015-01-19
LT2849746T (lt) 2018-02-12
JP2015516450A (ja) 2015-06-11
CA2873863A1 (en) 2013-11-21
RS56830B1 (sr) 2018-04-30
IL235652B (en) 2018-08-30
DK2849746T3 (en) 2017-12-04
IL235652A0 (en) 2015-01-29
AU2013262076A1 (en) 2015-01-22
HUE035122T2 (en) 2018-05-02

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20220512