HK1203965A1 - Boron-based 4-hydroxytamoxifen and endoxifen prodrugs as treatment for breast cancer 4- - Google Patents
Boron-based 4-hydroxytamoxifen and endoxifen prodrugs as treatment for breast cancer 4-Info
- Publication number
- HK1203965A1 HK1203965A1 HK15104565.0A HK15104565A HK1203965A1 HK 1203965 A1 HK1203965 A1 HK 1203965A1 HK 15104565 A HK15104565 A HK 15104565A HK 1203965 A1 HK1203965 A1 HK 1203965A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- hydroxytamoxifen
- boron
- treatment
- breast cancer
- endoxifen
- Prior art date
Links
- MHJBZVSGOZTKRH-IZHYLOQSSA-N 4-Hydroxy-N-desmethyltamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCNC)=CC=1)/C1=CC=C(O)C=C1 MHJBZVSGOZTKRH-IZHYLOQSSA-N 0.000 title 1
- DODQJNMQWMSYGS-QPLCGJKRSA-N 4-[(z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-phenylbut-1-en-2-yl]phenol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 DODQJNMQWMSYGS-QPLCGJKRSA-N 0.000 title 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 title 1
- 206010006187 Breast cancer Diseases 0.000 title 1
- 208000026310 Breast neoplasm Diseases 0.000 title 1
- 229910052796 boron Inorganic materials 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/027—Organoboranes and organoborohydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261634680P | 2012-03-05 | 2012-03-05 | |
| PCT/US2013/029059 WO2013134230A1 (en) | 2012-03-05 | 2013-03-05 | Boron-based 4-hydroxytamoxifen and endoxifen prodrugs as treatment for breast cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1203965A1 true HK1203965A1 (en) | 2015-11-06 |
Family
ID=49117248
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15104565.0A HK1203965A1 (en) | 2012-03-05 | 2015-05-14 | Boron-based 4-hydroxytamoxifen and endoxifen prodrugs as treatment for breast cancer 4- |
| HK18111893.5A HK1252579A1 (zh) | 2012-03-05 | 2018-09-17 | 作為用於治療乳腺癌的基於硼的4-羥基他莫昔芬和因多昔芬前藥 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18111893.5A HK1252579A1 (zh) | 2012-03-05 | 2018-09-17 | 作為用於治療乳腺癌的基於硼的4-羥基他莫昔芬和因多昔芬前藥 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9353132B2 (de) |
| EP (2) | EP2822955B1 (de) |
| CN (1) | CN104203961B (de) |
| HK (2) | HK1203965A1 (de) |
| WO (1) | WO2013134230A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104662028B (zh) * | 2012-06-25 | 2017-05-24 | 托马斯杰弗逊大学 | 对具有异常的脂肪生成信号的癌症进行治疗的组合物和方法 |
| AU2015259294A1 (en) * | 2014-05-12 | 2016-12-01 | Quest Diagnostics Investments Llc | Quantitation of tamoxifen and metabolites thereof by mass spectrometry |
| US10112962B2 (en) * | 2014-07-02 | 2018-10-30 | Xavier University | Boron-based prodrug strategy for increased bioavailability and lower-dosage requirements for drug molecules containing at least one phenol (or aromatic hydroxyl) group |
| BR112017025097B1 (pt) * | 2015-05-27 | 2021-05-11 | Quest Diagnostics Investments Llc | método para quantificação espectrométrica de massa de analitos extraídos de um dispositivo de microamostragem |
| CN104945426B (zh) * | 2015-06-12 | 2017-01-25 | 沧州普瑞东方科技有限公司 | 一种合成芳基三氟硼酸钾的方法 |
| CA2992282A1 (en) * | 2015-07-14 | 2017-01-19 | Atossa Genetics Inc. | Transpapillary methods and compositions for treating breast disorders |
| KR20200052349A (ko) | 2017-09-11 | 2020-05-14 | 아토사 테라퓨틱스, 인크. | 엔독시펜을 제조 및 사용하는 방법 |
| CN107674051B (zh) * | 2017-09-20 | 2021-01-08 | 南京医科大学 | 4-羟基他莫昔酚环状衍生物乏氧活化前药及其药物用途 |
| US20220041629A1 (en) * | 2018-09-12 | 2022-02-10 | Xavier University Of Louisiana | Estrogen receptor targeting antagonists |
| CN112321625A (zh) * | 2020-11-30 | 2021-02-05 | 河西学院 | 一种基于叶酸的mida硼酸酯-萘二甲酰亚胺类化合物及其制备与应用 |
| US20240058318A1 (en) * | 2020-12-10 | 2024-02-22 | Mayo Foundation For Medical Education And Research | Degrading pkcb1 to treat cancer |
| CN112979686B (zh) * | 2021-02-08 | 2022-04-08 | 北京大学 | 一种新型硼携带剂、制备方法及其药物制剂 |
| WO2022217010A1 (en) * | 2021-04-09 | 2022-10-13 | Endotarget Inc. | Compounds and methods for the targeted degradation of estrogen receptors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE637389A (de) | 1962-09-13 | |||
| US3288806A (en) | 1964-03-23 | 1966-11-29 | Parke Davis & Co | Alpha-(aminoethoxyphenyl)-alpha-alkylstilbenes |
| US5554628A (en) * | 1994-09-20 | 1996-09-10 | Eli Lilly And Company | Method for minimizing the uterothrophic effect of tamoxifen and tamoxifen analogs |
| CN1163567A (zh) | 1994-09-20 | 1997-10-29 | 伊莱利利公司 | 减低他莫昔芬和他莫昔芬类似物子宫营养影响的方法 |
| CA2348853A1 (en) * | 2001-05-25 | 2002-11-25 | Mcmaster University | Novel carborane analogs of tamoxifen |
-
2013
- 2013-03-05 US US14/382,356 patent/US9353132B2/en active Active
- 2013-03-05 EP EP13758606.1A patent/EP2822955B1/de active Active
- 2013-03-05 WO PCT/US2013/029059 patent/WO2013134230A1/en active Application Filing
- 2013-03-05 CN CN201380017207.3A patent/CN104203961B/zh active Active
- 2013-03-05 EP EP17182839.5A patent/EP3296300B1/de active Active
-
2015
- 2015-05-14 HK HK15104565.0A patent/HK1203965A1/xx unknown
-
2018
- 2018-09-17 HK HK18111893.5A patent/HK1252579A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20150080339A1 (en) | 2015-03-19 |
| EP2822955B1 (de) | 2017-07-26 |
| US9353132B2 (en) | 2016-05-31 |
| EP2822955A4 (de) | 2015-07-29 |
| EP3296300A1 (de) | 2018-03-21 |
| EP2822955A1 (de) | 2015-01-14 |
| CN104203961A (zh) | 2014-12-10 |
| EP3296300B1 (de) | 2019-08-07 |
| HK1252579A1 (zh) | 2019-05-31 |
| WO2013134230A1 (en) | 2013-09-12 |
| CN104203961B (zh) | 2017-05-17 |
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