HK1202553A1 - Lupane triterpenoid derivatives and pharmaceutical use thereof - Google Patents
Lupane triterpenoid derivatives and pharmaceutical use thereofInfo
- Publication number
- HK1202553A1 HK1202553A1 HK15103034.5A HK15103034A HK1202553A1 HK 1202553 A1 HK1202553 A1 HK 1202553A1 HK 15103034 A HK15103034 A HK 15103034A HK 1202553 A1 HK1202553 A1 HK 1202553A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pharmaceutical use
- triterpenoid derivatives
- lupane
- lupane triterpenoid
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210027090 | 2012-02-08 | ||
CN201310014849.XA CN103242413B (zh) | 2012-02-08 | 2013-01-15 | Lupane三萜系衍生物及其药学用途 |
PCT/CN2013/071100 WO2013117137A1 (en) | 2012-02-08 | 2013-01-30 | Lupane triterpenoid derivatives and pharmaceutical use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1202553A1 true HK1202553A1 (en) | 2015-10-02 |
Family
ID=48922317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15103034.5A HK1202553A1 (en) | 2012-02-08 | 2015-03-25 | Lupane triterpenoid derivatives and pharmaceutical use thereof |
Country Status (12)
Country | Link |
---|---|
US (1) | US9428542B2 (de) |
EP (1) | EP2812343B1 (de) |
JP (1) | JP5872074B2 (de) |
KR (1) | KR20140126739A (de) |
CN (1) | CN103242413B (de) |
AU (1) | AU2013218441A1 (de) |
BR (1) | BR112014018953A8 (de) |
CA (1) | CA2860581A1 (de) |
EA (1) | EA201491479A1 (de) |
HK (1) | HK1202553A1 (de) |
WO (1) | WO2013117137A1 (de) |
ZA (1) | ZA201405819B (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014105926A1 (en) | 2012-12-31 | 2014-07-03 | Hetero Research Foundation | Novel betulinic acid proline derivatives as hiv inhibitors |
US20170129916A1 (en) | 2014-06-26 | 2017-05-11 | Hetero Research Foundation | Novel betulinic proline imidazole derivatives as hiv inhibitors |
WO2016077569A1 (en) * | 2014-11-14 | 2016-05-19 | Bristol-Myers Squibb Company | C17-aryl substituted betulinic acid analogs |
JP6620149B2 (ja) * | 2014-11-14 | 2019-12-11 | ヴィーブ ヘルスケア ユーケー(ナンバー5)リミテッド | 拡張ベツリン酸類似体 |
EP3218387A1 (de) * | 2014-11-14 | 2017-09-20 | VIIV Healthcare UK (No.5) Limited | Oxolupenderivate |
MA40886B1 (fr) | 2015-02-09 | 2020-03-31 | Hetero Research Foundation | Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih |
WO2016147099A2 (en) | 2015-03-16 | 2016-09-22 | Hetero Research Foundation | C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors |
WO2018029602A1 (en) * | 2016-08-08 | 2018-02-15 | Hetero Labs Limited | C-3 novel triterpenone with c-28 heterocycle derivatives as hiv inhibitors |
WO2018029604A1 (en) * | 2016-08-08 | 2018-02-15 | Hetero Labs Limited | C-3 novel triterpenone with c-17 reverse amide derivatives as hiv inhibitors |
WO2018029610A1 (en) * | 2016-08-09 | 2018-02-15 | Hetero Labs Limited | C-3 novel triterpenone with c-17 n-amide derivatives as hiv inhibitors |
WO2018065930A1 (en) * | 2016-10-05 | 2018-04-12 | Hetero Labs Limited | C-3 triterpenone with c-17 reverse amide derivatives as hiv inhibitors |
WO2018069857A1 (en) * | 2016-10-12 | 2018-04-19 | Hetero Labs Limited | C-3 novel triterpenone with c-17 reverse amide heterocycle derivatives as hiv inhibitors |
WO2019150300A1 (en) | 2018-02-02 | 2019-08-08 | Glaxosmithkline Intellectual Property (No.2) Limited | Crystalline forms of 4-(((3ar,5ar,5br,7ar,9s,11ar,11br,13as)-3a-((r)-2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2h-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid |
PL237998B1 (pl) | 2018-05-28 | 2021-06-28 | Narodowy Inst Lekow | Fosfonowe pochodne kwasu 3-karboksyacylobetulinowego, sposób ich otrzymywania oraz ich zastosowanie |
CN114369134A (zh) * | 2020-10-15 | 2022-04-19 | 江西青峰药业有限公司 | 一种Lupane三萜系衍生物葡甲胺盐无定型物及其制备方法和应用 |
CN115504947B (zh) * | 2022-08-23 | 2024-04-26 | 山东和源制药有限公司 | 一种呋喃酮酸的制备方法 |
CN116041415B (zh) * | 2023-02-01 | 2023-08-18 | 吉林农业大学 | 一种裂环羽扇豆烷衍生物及其制备方法与应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008127364A2 (en) * | 2006-10-13 | 2008-10-23 | Myriad Genetics, Inc. | Antiviral compounds and use thereof |
US9505800B2 (en) * | 2006-11-03 | 2016-11-29 | Myrexis, Inc. | Extended triterpene derivatives |
WO2009073818A1 (en) * | 2007-12-04 | 2009-06-11 | Myriad Genetics, Inc. | Compounds and therapeutic use thereof |
WO2009082818A1 (en) * | 2008-01-03 | 2009-07-09 | Virochem Pharma Inc. | Novel c-21-keto lupane derivatives preparation and use thereof |
MX2010007375A (es) * | 2008-01-03 | 2010-09-30 | Virochem Pharma Inc | Nuevos derivados de lupano. |
EA201290632A1 (ru) | 2010-02-11 | 2013-03-29 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Производные бетулина |
JO3387B1 (ar) * | 2011-12-16 | 2019-03-13 | Glaxosmithkline Llc | مشتقات بيتولين |
-
2013
- 2013-01-15 CN CN201310014849.XA patent/CN103242413B/zh active Active
- 2013-01-30 CA CA2860581A patent/CA2860581A1/en not_active Abandoned
- 2013-01-30 US US14/374,832 patent/US9428542B2/en active Active
- 2013-01-30 WO PCT/CN2013/071100 patent/WO2013117137A1/en active Application Filing
- 2013-01-30 EP EP13746137.2A patent/EP2812343B1/de active Active
- 2013-01-30 EA EA201491479A patent/EA201491479A1/ru unknown
- 2013-01-30 JP JP2014555064A patent/JP5872074B2/ja not_active Expired - Fee Related
- 2013-01-30 BR BR112014018953A patent/BR112014018953A8/pt not_active IP Right Cessation
- 2013-01-30 AU AU2013218441A patent/AU2013218441A1/en not_active Abandoned
- 2013-01-30 KR KR1020147025188A patent/KR20140126739A/ko not_active Application Discontinuation
-
2014
- 2014-08-07 ZA ZA2014/05819A patent/ZA201405819B/en unknown
-
2015
- 2015-03-25 HK HK15103034.5A patent/HK1202553A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US20150011517A1 (en) | 2015-01-08 |
US9428542B2 (en) | 2016-08-30 |
KR20140126739A (ko) | 2014-10-31 |
ZA201405819B (en) | 2015-12-23 |
CN103242413A (zh) | 2013-08-14 |
EP2812343B1 (de) | 2019-03-13 |
JP5872074B2 (ja) | 2016-03-01 |
WO2013117137A1 (en) | 2013-08-15 |
BR112014018953A2 (de) | 2017-06-20 |
CN103242413B (zh) | 2015-08-26 |
BR112014018953A8 (pt) | 2017-07-11 |
CA2860581A1 (en) | 2013-08-15 |
AU2013218441A1 (en) | 2014-07-24 |
EP2812343A4 (de) | 2015-12-02 |
EA201491479A1 (ru) | 2014-11-28 |
EP2812343A1 (de) | 2014-12-17 |
JP2015505545A (ja) | 2015-02-23 |
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