HK1201449A1 - 使用 抑制劑來治療神經性疼痛 - Google Patents

使用 抑制劑來治療神經性疼痛

Info

Publication number
HK1201449A1
HK1201449A1 HK15101946.6A HK15101946A HK1201449A1 HK 1201449 A1 HK1201449 A1 HK 1201449A1 HK 15101946 A HK15101946 A HK 15101946A HK 1201449 A1 HK1201449 A1 HK 1201449A1
Authority
HK
Hong Kong
Prior art keywords
seh
neuropathic pain
inhibitors
treating neuropathic
treating
Prior art date
Application number
HK15101946.6A
Other languages
English (en)
Inventor
‧哈莫克
‧李
‧因杰奧盧
‧瓦格納
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of HK1201449A1 publication Critical patent/HK1201449A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK15101946.6A 2012-02-01 2015-02-26 使用 抑制劑來治療神經性疼痛 HK1201449A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261593811P 2012-02-01 2012-02-01
PCT/US2013/024429 WO2013116713A1 (en) 2012-02-01 2013-02-01 Treating neuropathic pain with seh inhibitors

Publications (1)

Publication Number Publication Date
HK1201449A1 true HK1201449A1 (zh) 2015-09-04

Family

ID=48905897

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15101946.6A HK1201449A1 (zh) 2012-02-01 2015-02-26 使用 抑制劑來治療神經性疼痛

Country Status (5)

Country Link
US (1) US9850207B2 (zh)
EP (1) EP2809314A4 (zh)
CN (1) CN104136022A (zh)
HK (1) HK1201449A1 (zh)
WO (1) WO2013116713A1 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104093708B (zh) * 2012-02-01 2016-11-09 加利福尼亚大学董事会 可溶性环氧化物水解酶的酰基哌啶抑制剂
ES2871027T3 (es) 2014-03-27 2021-10-28 Eicosis Llc Inhibidores potentes de la epóxido hidrolasa soluble
US10813894B2 (en) * 2015-02-20 2020-10-27 The Regents Of The University Of California Methods of inhibiting pain
CN108658897B (zh) * 2017-03-30 2022-02-15 上海医药工业研究院 乙酰苄胺哌嗪和/或哌啶类衍生物及其作为脑神经保护剂的应用
WO2019156991A1 (en) * 2018-02-06 2019-08-15 The Regents Of The University Of California Methods of inhibiting formation of alpha synuclein aggregates
US20190381138A1 (en) * 2018-05-17 2019-12-19 Helixmith Co., Ltd. Treatment of neuropathic pain associated with chemotherapy-induced peripheral neuropathy
CN111574432A (zh) * 2020-06-17 2020-08-25 安徽省逸欣铭医药科技有限公司 一种可溶性环氧水解酶和γ-氨基丁酸双重抑制剂及用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR058277A1 (es) * 2005-12-09 2008-01-30 Solvay Pharm Gmbh N- sulfamoil - piperidin - amidas, composiciones farmaceuticas que las comprenden y procedimiento para su preparacion
TW200825072A (en) * 2006-10-20 2008-06-16 Arete Therapeutics Inc Soluble epoxide hydrolase inhibitors
CN101535259A (zh) * 2006-10-20 2009-09-16 亚瑞特医疗公司 作为可溶性环氧化物水解酶抑制剂的苯基脲化合物
EP2219450A4 (en) * 2007-11-08 2012-01-25 Univ California RELIEF OF NEUROPATHIC PAIN USING EET AND SEH INHIBITORS
US20090247521A1 (en) * 2007-12-28 2009-10-01 Arete Therapeutics, Inc. Soluble epoxide hydrolase inhibitors for the treatment of endothelial dysfunction

Also Published As

Publication number Publication date
US9850207B2 (en) 2017-12-26
WO2013116713A9 (en) 2013-10-03
CN104136022A (zh) 2014-11-05
WO2013116713A1 (en) 2013-08-08
EP2809314A1 (en) 2014-12-10
US20150065540A1 (en) 2015-03-05
EP2809314A4 (en) 2015-07-08

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