HK1200752A1 - 用於集成的樣品製備、反應和檢測的設備與方法 - Google Patents

用於集成的樣品製備、反應和檢測的設備與方法

Info

Publication number
HK1200752A1
HK1200752A1 HK15101264.0A HK15101264A HK1200752A1 HK 1200752 A1 HK1200752 A1 HK 1200752A1 HK 15101264 A HK15101264 A HK 15101264A HK 1200752 A1 HK1200752 A1 HK 1200752A1
Authority
HK
Hong Kong
Prior art keywords
reaction
detection
methods
sample preparation
integrated sample
Prior art date
Application number
HK15101264.0A
Other languages
English (en)
Inventor
赫蘇斯．清
菲利普．尤．輝．李
布魯斯．理查森
Original Assignee
盧米耐克斯公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 盧米耐克斯公司 filed Critical 盧米耐克斯公司
Publication of HK1200752A1 publication Critical patent/HK1200752A1/zh

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/65—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being directly submitted to a pulsating movement, e.g. by means of an oscillating piston or air column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/715—Feeding the components in several steps, e.g. successive steps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7174—Feed mechanisms characterised by the means for feeding the components to the mixer using pistons, plungers or syringes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0265—Drop counters; Drop formers using valves to interrupt or meter fluid flow, e.g. using solenoids or metering valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/028—Modular arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0672—Integrated piercing tool
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B01L3/527—Containers specially adapted for storing or dispensing a reagent for a plurality of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
HK15101264.0A 2011-05-04 2015-02-05 用於集成的樣品製備、反應和檢測的設備與方法 HK1200752A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161482494P 2011-05-04 2011-05-04
US201161497401P 2011-06-15 2011-06-15
PCT/US2012/036491 WO2012151473A2 (en) 2011-05-04 2012-05-04 Apparatus and methods for integrated sample preparation, reaction and detection

Publications (1)

Publication Number Publication Date
HK1200752A1 true HK1200752A1 (zh) 2015-08-14

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
HK15101264.0A HK1200752A1 (zh) 2011-05-04 2015-02-05 用於集成的樣品製備、反應和檢測的設備與方法
HK18104389.1A HK1244835A1 (zh) 2011-05-04 2018-04-03 用於集成的樣品製備、反應和檢測的設備與方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK18104389.1A HK1244835A1 (zh) 2011-05-04 2018-04-03 用於集成的樣品製備、反應和檢測的設備與方法

Country Status (7)

Country Link
US (2) US9248422B2 (zh)
EP (2) EP3081301B1 (zh)
CN (2) CN104023834B (zh)
AU (2) AU2012250619B2 (zh)
CA (1) CA2834790C (zh)
HK (2) HK1200752A1 (zh)
WO (1) WO2012151473A2 (zh)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005027714A2 (en) 2003-07-12 2005-03-31 Accelr8 Technology Corporation Sensitive and rapid biodetection
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
BR112012021202B1 (pt) 2010-02-23 2020-06-09 Genturadx Usa Inc aparelho e métodos para preparação, reação e detecção integradas de amostras
US8877464B2 (en) * 2010-07-29 2014-11-04 Roche Molecular Systems, Inc. Qualitative and quantitative detection of microbial nucleic acids
JP5887041B2 (ja) * 2010-08-02 2016-03-16 ウェイト、ブレント、エル． ポリメラーゼ連鎖反応のための加圧可能なカートリッジ
EP2683831B1 (en) 2011-03-07 2015-09-23 Accelerate Diagnostics, Inc. Rapid cell purification systems
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
MX2015009264A (es) 2013-01-18 2016-03-31 Biomeme Inc Dispositivo analitico.
CN110938671A (zh) 2013-03-13 2020-03-31 经纬生物科技有限公司 非复制型转导颗粒和基于转导颗粒的报告系统
US9481903B2 (en) 2013-03-13 2016-11-01 Roche Molecular Systems, Inc. Systems and methods for detection of cells using engineered transduction particles
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
US9540675B2 (en) 2013-10-29 2017-01-10 GeneWeave Biosciences, Inc. Reagent cartridge and methods for detection of cells
MX2016005480A (es) 2013-11-01 2016-08-03 Biomeme Inc Dispositivo de preparacion y extraccion de muestras.
WO2015088942A1 (en) 2013-12-12 2015-06-18 3M Innovative Properties Company Apparatus and method for preparing a biological sample for analysis
US10195610B2 (en) 2014-03-10 2019-02-05 Click Diagnostics, Inc. Cartridge-based thermocycler
US9827567B2 (en) 2014-04-22 2017-11-28 Nanosphere, Inc. Diagnostic cartridges having flexible seals
US9937494B2 (en) * 2014-06-16 2018-04-10 Life Technologies Corporation Reagent mixer and fluid control devices
US9890424B2 (en) 2014-06-17 2018-02-13 Life Technologies Corporation Sequencing device
KR102465287B1 (ko) 2014-08-11 2022-11-09 루미넥스 코포레이션 핵산 검정에서 개선된 용융 판별 및 멀티플렉싱을 위한 프로브
WO2016089477A1 (en) * 2014-10-16 2016-06-09 Cepheid Biosecurity screening system and method
CA2972587A1 (en) 2014-12-31 2016-07-07 Click Diagnostics, Inc. Devices and methods for molecular diagnostic testing
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
AU2016243656A1 (en) 2015-03-30 2017-11-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
JP6433398B2 (ja) * 2015-09-25 2018-12-05 ウシオ電機株式会社 光学測定器
US10351893B2 (en) 2015-10-05 2019-07-16 GeneWeave Biosciences, Inc. Reagent cartridge for detection of cells
CN116859069A (zh) 2016-02-17 2023-10-10 贝克顿·迪金森公司 用于相同的诊断测试的自动化样品制备系统
WO2017145080A1 (en) * 2016-02-23 2017-08-31 Bigtec Private Limited A cartridge for purifying a sample and analysis
CN109073664B (zh) 2016-04-22 2022-12-06 贝克顿·迪金森公司 自动诊断分析仪及其操作方法
US10987674B2 (en) 2016-04-22 2021-04-27 Visby Medical, Inc. Printed circuit board heater for an amplification module
CN115754323A (zh) 2016-04-22 2023-03-07 贝克顿·迪金森公司 自动化诊断分析仪和用于自动化诊断分析仪的操作的方法
WO2017197040A1 (en) 2016-05-11 2017-11-16 Click Diagnostics, Inc. Devices and methods for nucleic acid extraction
WO2018005710A1 (en) 2016-06-29 2018-01-04 Click Diagnostics, Inc. Devices and methods for the detection of molecules using a flow cell
USD800331S1 (en) 2016-06-29 2017-10-17 Click Diagnostics, Inc. Molecular diagnostic device
USD800913S1 (en) 2016-06-30 2017-10-24 Click Diagnostics, Inc. Detection window for molecular diagnostic device
USD800914S1 (en) 2016-06-30 2017-10-24 Click Diagnostics, Inc. Status indicator for molecular diagnostic device
AU2017290753B2 (en) * 2016-06-30 2021-12-09 Visby Medical, Inc. Devices and methods for nucleic acid extraction
US11077444B2 (en) 2017-05-23 2021-08-03 Roche Molecular Systems, Inc. Packaging for a molecular diagnostic cartridge
CA3069984A1 (en) 2017-07-27 2019-01-31 Biomerieux, Inc. Isolation tube
US11207674B2 (en) * 2017-08-09 2021-12-28 Biogx, Inc. Method of customizing a universal reagent cartridge with a lyophilized target-specific reagent
EP3707276A4 (en) * 2017-11-09 2022-02-23 Visby Medical, Inc. PORTABLE MOLECULAR DIAGNOSTIC DEVICE AND METHODS FOR DETECTING TARGET VIRUSES
US11459604B2 (en) 2018-07-12 2022-10-04 Luminex Corporation Systems and methods for performing variable sample preparation and analysis processes
DE102018131088A1 (de) * 2018-12-05 2020-06-10 Biofluidix Gmbh Flüssigkeitsdosiervorrichtung zur ballistischen Abgabe von Dosiermengen im Nanoliterbereich, Flüssigkeitsdosierverfahren und Pipettierspitze hierfür
CA3131142A1 (en) 2019-03-21 2020-09-24 Peter EISENHOWER Multi-function analytic devices
CN110195017B (zh) * 2019-06-11 2022-04-15 郑州大学第二附属医院 一种帕金森病致病基因突变筛查检测方法
WO2021138544A1 (en) 2020-01-03 2021-07-08 Visby Medical, Inc. Devices and methods for antibiotic susceptibility testing
US20210299668A1 (en) * 2020-03-30 2021-09-30 Singular Genomics Systems, Inc. Sequencing system with preheating
CN111790462B (zh) * 2020-08-13 2024-01-09 河南默深智工医疗科技有限公司 一种微流控检测用加热装置
JP2023545631A (ja) 2020-09-18 2023-10-31 バイオミーム，インコーポレイテッド 試料を分析するための運搬可能デバイスおよび方法
CN112858161B (zh) * 2021-01-12 2022-03-11 西南石油大学 一种测定气体水合物和管道壁面粘附力的装置及方法
CN113174324B (zh) * 2021-01-15 2022-03-11 北京中科生仪科技有限公司 Pcr反应装置

Family Cites Families (228)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2940448A (en) * 1957-04-29 1960-06-14 Jr Norman B Furlong Disposable blood-gas analyzer
SE327840B (zh) 1968-01-25 1970-08-31 Atuokemi Ab
US3802782A (en) 1970-08-19 1974-04-09 Rohe Scientific Corp Chemical analyzer performing sequential analysis of samples
US4004150A (en) 1975-05-01 1977-01-18 Samuel Natelson Analytical multiple component readout system
US4201578A (en) 1977-11-03 1980-05-06 Eastman Kodak Company Blocked competing developers for color transfer
US4448534A (en) 1978-03-30 1984-05-15 American Hospital Corporation Antibiotic susceptibility testing
FI63296C (fi) 1980-07-11 1983-05-10 Eflab Oy Fotometer
JPS5848836A (ja) 1981-09-18 1983-03-22 Toa Medical Electronics Co Ltd 光学式自動分析測定装置
US4626684A (en) 1983-07-13 1986-12-02 Landa Isaac J Rapid and automatic fluorescence immunoassay analyzer for multiple micro-samples
US5500188A (en) * 1984-03-01 1996-03-19 Molecular Devices Corporation Device for photoresponsive detection and discrimination
DE3441179A1 (de) 1984-11-10 1986-05-22 Dynatech Deutschland GmbH, 7306 Denkendorf Temperiereinrichtung fuer mikrokuevettenanordnungen, insbesondere mikrotitrationsplatten
US5656493A (en) 1985-03-28 1997-08-12 The Perkin-Elmer Corporation System for automated performance of the polymerase chain reaction
US5333675C1 (en) 1986-02-25 2001-05-01 Perkin Elmer Corp Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US5164598A (en) 1985-08-05 1992-11-17 Biotrack Capillary flow device
GB8607975D0 (en) 1986-04-01 1986-05-08 Fisons Plc Devices
US6645758B1 (en) 1989-02-03 2003-11-11 Johnson & Johnson Clinical Diagnostics, Inc. Containment cuvette for PCR and method of use
US5229297A (en) 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
DK374889D0 (da) 1989-07-28 1989-07-28 Koege Kemisk Vaerk Fremgangsmaade til procesovervaagning
JPH06100538B2 (ja) 1989-08-02 1994-12-12 株式会社日立製作所 原子吸光分光光度計
US5283624A (en) 1989-10-18 1994-02-01 Hitachi, Ltd. Multi-element simultaneous analysis atomic absorption spectroscopy photometer and multi-element simultaneous analytic method
US5073029A (en) 1990-02-16 1991-12-17 Eqm Research, Inc. Multisource device for photometric analysis and associated chromogens
ATE188509T1 (de) 1990-02-16 2000-01-15 Hoffmann La Roche Verbesserungen in der spezifität und zweckmässigkeit der polymerase-kettenreaktion
US5139745A (en) 1990-03-30 1992-08-18 Block Medical, Inc. Luminometer
JPH0678978B2 (ja) 1990-05-25 1994-10-05 スズキ株式会社 凝集パターン検出装置
US6787338B2 (en) 1990-06-04 2004-09-07 The University Of Utah Method for rapid thermal cycling of biological samples
US5935522A (en) 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US5541072A (en) 1994-04-18 1996-07-30 Immunivest Corporation Method for magnetic separation featuring magnetic particles in a multi-phase system
US5188455A (en) 1990-11-13 1993-02-23 The Pennsylvania Research Corporation Apparatus for remote mixing of fluids
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
US5242837A (en) 1990-12-24 1993-09-07 Slovacek Rudolf E Method for the rapid detection of analytes involving specific binding reactions and the use of light attenuating magnetic particles
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
CA2069537A1 (en) 1991-06-07 1992-12-08 Thomas A. Cook Multiple output referencing system for evanescent wave sensor
DE4123817C2 (de) 1991-07-18 1994-06-09 Berthold Lab Prof Dr Strahlungsmeßgerät, insbesondere zur Messung der Lumineszenz
JPH05157684A (ja) 1991-12-02 1993-06-25 Seikagaku Kogyo Co Ltd 吸光光度計
US5348853A (en) 1991-12-16 1994-09-20 Biotronics Corporation Method for reducing non-specific priming in DNA amplification
US5242660A (en) 1992-02-28 1993-09-07 Paul Hsei Sample preparation device
EP1130116A3 (en) 1992-04-06 2004-01-14 Abbott Laboratories Method and device for detection of nucleic acid using total internal reflectance
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5897783A (en) 1992-09-24 1999-04-27 Amersham International Plc Magnetic separation method
US5538849A (en) 1992-12-29 1996-07-23 Toyo Boseki Kabushiki Kaisha Apparatus for automated assay of DNA probe and method for assaying nucleic acid in sample
WO1994018218A1 (en) 1993-02-01 1994-08-18 Seq, Ltd. Methods and apparatus for dna sequencing
US5494646A (en) 1993-04-14 1996-02-27 Seymour; Eugene H. Sampling device and sample adequacy system
US5861124A (en) 1993-07-15 1999-01-19 Hamamatsu Photonics Kk Method and apparatus for detecting denaturation of nucleic acid
GB9314991D0 (en) 1993-07-20 1993-09-01 Sandoz Ltd Mechanical device
ATE208658T1 (de) 1993-07-28 2001-11-15 Pe Corp Ny Vorrichtung und verfahren zur nukleinsäurevervielfältigung
US5436718A (en) 1993-07-30 1995-07-25 Biolumin Corporation Mutli-functional photometer with movable linkage for routing optical fibers
US5397709A (en) 1993-08-27 1995-03-14 Becton Dickinson And Company System for detecting bacterial growth in a plurality of culture vials
JP3326708B2 (ja) 1993-08-31 2002-09-24 日水製薬株式会社 光学的測定装置およびその方法
CA2130013C (en) 1993-09-10 1999-03-30 Rolf Moser Apparatus for automatic performance of temperature cycles
US5525300A (en) 1993-10-20 1996-06-11 Stratagene Thermal cycler including a temperature gradient block
US5645801A (en) 1993-10-21 1997-07-08 Abbott Laboratories Device and method for amplifying and detecting target nucleic acids
US5415839A (en) 1993-10-21 1995-05-16 Abbott Laboratories Apparatus and method for amplifying and detecting target nucleic acids
US5503805A (en) 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
US5580523A (en) 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
CA2159830C (en) 1994-04-29 2001-07-03 Timothy M Woudenberg System for real time detection of nucleic acid amplification products
SE9401594D0 (sv) 1994-05-06 1994-05-06 Pharmacia Lkb Biotech Method of nucleic acid transfer
US5511558A (en) * 1994-06-06 1996-04-30 Becton, Dickinson And Company Blood collection assembly having additive dispensing means and method for sample collection using same
US5976896A (en) 1994-06-06 1999-11-02 Idexx Laboratories, Inc. Immunoassays in capillary tubes
DE4420732A1 (de) 1994-06-15 1995-12-21 Boehringer Mannheim Gmbh Vorrichtung zur Behandlung von Nukleinsäuren aus einer Probe
US5837144A (en) 1994-06-16 1998-11-17 Boehringer Mannheim Gmbh Method of magnetically separating liquid components
US5508197A (en) 1994-07-25 1996-04-16 The Regents, University Of California High-speed thermal cycling system and method of use
US5627041A (en) 1994-09-02 1997-05-06 Biometric Imaging, Inc. Disposable cartridge for an assay of a biological sample
US5705628A (en) 1994-09-20 1998-01-06 Whitehead Institute For Biomedical Research DNA purification and isolation using magnetic particles
US5576197A (en) 1995-04-07 1996-11-19 Molecular Bio-Products Polymerase chain reaction container and methods of using the same
US5578818A (en) 1995-05-10 1996-11-26 Molecular Dynamics LED point scanning system
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US20020022261A1 (en) 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5686300A (en) 1995-09-11 1997-11-11 Becton Dickinson And Company Fluorescence detector
US5639668A (en) 1995-09-14 1997-06-17 Boehringer Mannheim Corporation Optical apparatus for performing an immunoassay
US6004512A (en) 1995-12-08 1999-12-21 Mj Research Sample cartridge slide block
US5657118A (en) 1996-01-23 1997-08-12 Lee; John T. S. Device and method for detection/measurement of light
US5661301A (en) 1996-02-07 1997-08-26 The Penn State Research Foundation Spectroscopy and mapping of atoms, molecules and surface features via difference frequency generation with a scanning tunneling microscope or related instruments
US5863801A (en) 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
US6074827A (en) 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US5882903A (en) 1996-11-01 1999-03-16 Sarnoff Corporation Assay system and method for conducting assays
US5825478A (en) 1996-11-15 1998-10-20 Wilcox; Steven Multifunctional photometer apparatus
AU5895898A (en) 1996-12-20 1998-07-17 Gamera Bioscience Corporation An affinity binding-based system for detecting particulates in a fluid
US6027945A (en) 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
DE19707226A1 (de) 1997-02-24 1998-08-27 Bodenseewerk Perkin Elmer Co Lichtabtastvorrichtung
ES2544455T3 (es) 1997-02-28 2015-08-31 Cepheid Montaje para reacción química con intercambio de calor, ópticamente interrogada
US6074868A (en) 1997-03-03 2000-06-13 Regents Of The University Of Minnesota Alumina plate method and device for controlling temperature
US6143496A (en) * 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US5989499A (en) 1997-05-02 1999-11-23 Biomerieux, Inc. Dual chamber disposable reaction vessel for amplification reactions
US6429007B1 (en) 1997-05-02 2002-08-06 BIOMéRIEUX, INC. Nucleic acid amplification reaction station for disposable test devices
FR2763396A1 (fr) 1997-05-15 1998-11-20 Tosoh Corp Appareil de dosage, et dispositif de support de recipients utilise avec ledit appareil
EP0983499B1 (en) 1997-05-23 2005-10-26 Becton, Dickinson and Company Automated microbiological testing apparatus and methods therefor
SE9702005D0 (sv) 1997-05-28 1997-05-28 Alphahelix Ab New reaction vessel and method for its use
US6071748A (en) 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
US6043506A (en) 1997-08-13 2000-03-28 Bio-Rad Laboratories, Inc. Multi parameter scanner
US6061128A (en) 1997-09-04 2000-05-09 Avocet Medical, Inc. Verification device for optical clinical assay systems
US6597450B1 (en) 1997-09-15 2003-07-22 Becton, Dickinson And Company Automated Optical Reader for Nucleic Acid Assays
US6222619B1 (en) 1997-09-18 2001-04-24 University Of Utah Research Foundation Diagnostic device and method
US6982431B2 (en) 1998-08-31 2006-01-03 Molecular Devices Corporation Sample analysis systems
US6297018B1 (en) 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
ES2309022T3 (es) 1997-12-24 2008-12-16 Cepheid Dispositivo y procedimiento para lisis.
US6050719A (en) 1998-01-30 2000-04-18 Affymetrix, Inc. Rotational mixing method using a cartridge having a narrow interior
JP3551293B2 (ja) 1998-02-02 2004-08-04 東洋紡績株式会社 核酸抽出装置
FI102906B1 (fi) 1998-02-23 1999-03-15 Bio Nobile Oy Menetelmä ja väline aineen siirtämiseksi
US6369893B1 (en) 1998-05-19 2002-04-09 Cepheid Multi-channel optical detection system
JP3813730B2 (ja) 1998-03-19 2006-08-23 浜松ホトニクス株式会社 蛍光測定装置
US7078224B1 (en) 1999-05-14 2006-07-18 Promega Corporation Cell concentration and lysate clearance using paramagnetic particles
US6057163A (en) 1998-04-28 2000-05-02 Turner Designs Luminescence and fluorescence quantitation system
ES2322859T3 (es) 1998-05-01 2009-06-30 Gen-Probe Incorporated Analizador de diagnostico automatizado.
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
US6818437B1 (en) 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
WO1999060397A1 (en) 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
US6232608B1 (en) 1998-08-18 2001-05-15 Molecular Devices Corporation Optimization systems in a scanning fluorometer
US6492162B1 (en) 1998-10-27 2002-12-10 Hitachi, Ltd. Apparatus for the recovery of nucleic acids
US6569631B1 (en) 1998-11-12 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
US6431476B1 (en) 1999-12-21 2002-08-13 Cepheid Apparatus and method for rapid ultrasonic disruption of cells or viruses
US6673620B1 (en) * 1999-04-20 2004-01-06 Cytologix Corporation Fluid exchange in a chamber on a microscope slide
US6838680B2 (en) 1999-05-12 2005-01-04 Aclara Biosciences, Inc. Multiplexed fluorescent detection in microfluidic devices
US7387891B2 (en) 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
US7423750B2 (en) 2001-11-29 2008-09-09 Applera Corporation Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion
US8815521B2 (en) 2000-05-30 2014-08-26 Cepheid Apparatus and method for cell disruption
US20040200909A1 (en) 1999-05-28 2004-10-14 Cepheid Apparatus and method for cell disruption
US6818185B1 (en) 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
US6706519B1 (en) 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
KR100865105B1 (ko) 1999-06-28 2008-10-24 캘리포니아 인스티튜트 오브 테크놀로지 마이크로 가공된 탄성중합체 밸브 및 펌프 시스템
US6353475B1 (en) 1999-07-12 2002-03-05 Caliper Technologies Corp. Light source power modulation for use with chemical and biochemical analysis
AU777180B2 (en) 1999-07-19 2004-10-07 Organon Teknika B.V. Device and method for mixing magnetic particles with a fluid
US6657169B2 (en) 1999-07-30 2003-12-02 Stratagene Apparatus for thermally cycling samples of biological material with substantial temperature uniformity
JP5006494B2 (ja) 1999-08-13 2012-08-22 バイエル・テクノロジー・サービシーズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 複数の分析物を測定するためのデバイス及び方法
JP4045475B2 (ja) 1999-09-06 2008-02-13 東洋紡績株式会社 核酸・蛋白質精製装置
JP3551860B2 (ja) 1999-10-05 2004-08-11 株式会社日立製作所 Ｄｎａ検査方法及びｄｎａ検査装置
US6699713B2 (en) 2000-01-04 2004-03-02 The Regents Of The University Of California Polymerase chain reaction system
US6358387B1 (en) 2000-03-27 2002-03-19 Caliper Technologies Corporation Ultra high throughput microfluidic analytical systems and methods
US6783934B1 (en) 2000-05-01 2004-08-31 Cepheid, Inc. Methods for quantitative analysis of nucleic acid amplification reaction
US6690467B1 (en) 2000-05-05 2004-02-10 Pe Corporation Optical system and method for optically analyzing light from a sample
GB0010910D0 (en) 2000-05-05 2000-06-28 Jones Osborn Analytical method and apparatus
US6672458B2 (en) 2000-05-19 2004-01-06 Becton, Dickinson And Company System and method for manipulating magnetically responsive particles fluid samples to collect DNA or RNA from a sample
US6520197B2 (en) 2000-06-02 2003-02-18 The Regents Of The University Of California Continuous laminar fluid mixing in micro-electromechanical systems
US6511277B1 (en) 2000-07-10 2003-01-28 Affymetrix, Inc. Cartridge loader and methods
WO2002014926A2 (en) 2000-08-15 2002-02-21 Nanostream, Inc. Optical devices with fluidic systems
US6545758B1 (en) 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer
US8048386B2 (en) 2002-02-25 2011-11-01 Cepheid Fluid processing and control
US7097809B2 (en) * 2000-10-03 2006-08-29 California Institute Of Technology Combinatorial synthesis system
US7142296B2 (en) 2000-10-30 2006-11-28 Sru Biosystems, Inc. Method and apparatus for detecting biomolecular interactions
US8097471B2 (en) * 2000-11-10 2012-01-17 3M Innovative Properties Company Sample processing devices
US6576459B2 (en) 2001-03-23 2003-06-10 The Regents Of The University Of California Sample preparation and detection device for infectious agents
GB0110476D0 (en) 2001-04-30 2001-06-20 Secr Defence Reagent delivery system
US6955589B2 (en) 2001-05-22 2005-10-18 Qed Technologies, Inc. Delivery system for magnetorheological fluid
US6825927B2 (en) 2001-06-15 2004-11-30 Mj Research, Inc. Controller for a fluorometer
US20030073110A1 (en) 2001-07-03 2003-04-17 Masaharu Aritomi Method for isolating nucleic acid and a cartridge for chemical reaction and for nucleic acid isolation
KR100451154B1 (ko) 2001-07-24 2004-10-02 엘지전자 주식회사 기판 내에서 유체를 조작하는 방법 및 이를 위한 장치
WO2003019158A2 (de) 2001-08-21 2003-03-06 Bestmann, Lukas Thermo-optisches analysesystem für biochemische reaktionen
JP5193408B2 (ja) 2001-09-13 2013-05-08 ベックマン コールター， インコーポレイテッド 自動分析装置
JP4558995B2 (ja) 2001-09-12 2010-10-06 ベックマン コールター， インコーポレイテッド 移送ユニットおよびその移送ユニットを備える自動分析装置
US7459302B2 (en) 2001-10-02 2008-12-02 Stratagene California Side-wall heater for thermocycler device
US6739531B2 (en) 2001-10-04 2004-05-25 Cepheid Apparatus and method for rapid disruption of cells or viruses
US7344894B2 (en) 2001-10-16 2008-03-18 Agilent Technologies, Inc. Thermal regulation of fluidic samples within a diagnostic cartridge
CA2462447A1 (en) 2001-10-19 2003-04-24 Monogen, Inc. Article handling system and method
KR100445560B1 (ko) 2001-10-31 2004-08-21 (주)바이오넥스 핵산 또는 생물학적 물질을 분리하기 위한 키트의 제조방법과, 그 방법에 의해 제조된 키트와, 그 키트를사용하는 장치
IL146404A0 (en) 2001-11-08 2002-07-25 E Afikin Computerized Dairy Ma Spectroscopic fluid analyzer
CA2469464A1 (en) 2001-12-07 2003-06-19 Dyax Corporation Method and apparatus for washing magnetically responsive particles
US7373253B2 (en) 2002-02-12 2008-05-13 Idaho Technology Multi-test analysis of real-time nucleic acid amplification
US20030203491A1 (en) 2002-04-26 2003-10-30 Andrevski Zygmunt M. Gravitational flow purification system
US7718072B2 (en) 2002-04-26 2010-05-18 Abbott Laboratories Structure and method for handling magnetic particles in biological assays
CA2489099C (en) * 2002-06-11 2012-12-18 Chempaq A/S A disposable cartridge for characterizing particles suspended in a liquid
US20040126783A1 (en) 2002-07-10 2004-07-01 Massachusetts Institute Of Technology Apparatus and method for isolating a nucleic acid from a sample
AU2003270832A1 (en) 2002-09-24 2004-04-19 U.S. Government As Represented By The Secretary Of The Army Portable thermocycler
US6730883B2 (en) 2002-10-02 2004-05-04 Stratagene Flexible heating cover assembly for thermal cycling of samples of biological material
GB0227765D0 (en) 2002-11-28 2003-01-08 Secr Defence Apparatus for processing a fluid sample
EP1608952B1 (en) 2002-12-20 2016-08-10 Life Technologies Corporation Assay apparatus and method using microfluidic arrays
US7584019B2 (en) 2003-12-15 2009-09-01 Dako Denmark A/S Systems and methods for the automated pre-treatment and processing of biological samples
US20060094108A1 (en) 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
KR100483684B1 (ko) 2003-01-29 2005-04-18 (주)바이오넥스 핵산 또는 다양한 생물학적 물질을 분리 및 정제하기 위한키트와, 이러한 키트를 이용하여 생물학적 물질의 분리또는 정제 작업을 자동화하기 위한 시스템
US7718421B2 (en) 2003-02-05 2010-05-18 Iquum, Inc. Sample processing
JP2006521092A (ja) 2003-04-04 2006-09-21 エフ．ホフマン−ラ　ロシュ　アーゲー マルチカラーリアルタイムｐｃｒ用の改良されたシステム
CN1767899A (zh) 2003-04-04 2006-05-03 皇家飞利浦电子股份有限公司 多微通道中的流体分隔
KR100528561B1 (ko) 2003-04-21 2005-11-16 엘지전자 주식회사 전자기력 구동 유량 제어 밸브 및 그의 제조방법과 이를이용한 열 교환 장치
DE10319045A1 (de) 2003-04-25 2004-12-09 november Aktiengesellschaft Gesellschaft für Molekulare Medizin Vorrichtung und Verfahren zur Aufbereitung Biopolymerhaltiger Flüssigkeiten
TW579430B (en) 2003-05-02 2004-03-11 Dr Chip Biotechnology Inc Automatic micro-fluid hybridization chip platform
US7148043B2 (en) 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
US8043846B2 (en) 2003-06-13 2011-10-25 The General Hospital Corporation Device and method for contacting picoliter volumes of fluid
WO2005011867A2 (en) 2003-07-31 2005-02-10 Handylab, Inc. Processing particle-containing samples
GB0323043D0 (en) 2003-09-24 2003-11-05 Lux Biotechnology Ltd Biochip
US7394547B2 (en) 2003-11-06 2008-07-01 Fortebio, Inc. Fiber-optic assay apparatus based on phase-shift interferometry
US20070281288A1 (en) 2004-01-27 2007-12-06 Shimshon Belkin Method and System for Detecting Analytes
US20060257991A1 (en) 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements
US7223949B2 (en) 2004-04-21 2007-05-29 Beckman Coulter, Inc. Analysis apparatus having improved temperature control unit
US20050244837A1 (en) 2004-04-28 2005-11-03 Cepheid Method and device for sample preparation control
CA2994321C (en) 2004-05-03 2023-08-08 Handylab, Inc. A microfluidic device and methods for processing polynucleotide-containing samples
WO2005111243A2 (en) 2004-05-07 2005-11-24 Cepheid Multiplexed detection of biological agents
AU2005253151B2 (en) 2004-06-07 2010-08-19 Iquum, Inc. Sample multiprocessing
US7585663B2 (en) 2004-08-26 2009-09-08 Applied Biosystems, Llc Thermal device, system, and method, for fluid processing device
DE102004042987A1 (de) 2004-09-06 2006-03-23 Roche Diagnostics Gmbh Push-Pull betriebene Pumpe für ein mikrofluidisches System
EP2261650A3 (en) 2004-09-15 2011-07-06 IntegenX Inc. Microfluidic devices
AU2005299590B2 (en) 2004-10-27 2010-09-16 Cepheid Closed-system multi-stage nucleic acid amplification reactions
CN101437615A (zh) * 2004-12-21 2009-05-20 法斯特拉克公司 用于诊断化验的试样盒
US20060165558A1 (en) * 2004-12-21 2006-07-27 Thomas Witty Cartridge for diagnostic assays
US8883487B2 (en) 2004-12-23 2014-11-11 Abbott Point Of Care Inc. Molecular diagnostics system and methods
US7699979B2 (en) 2005-01-07 2010-04-20 Board Of Trustees Of The University Of Arkansas Separation system and efficient capture of contaminants using magnetic nanoparticles
JP3921233B2 (ja) 2005-02-10 2007-05-30 松下電器産業株式会社 流体チップ、それを用いた流体移動制御方法、および化学反応装置
CA2597919A1 (en) 2005-02-15 2006-08-24 University Of Virginia Patent Foundation Nucleic acid isolation methods and materials and devices thereof
EP2333561A3 (en) 2005-03-10 2014-06-11 Gen-Probe Incorporated System for performing multi-formatted assays
US7507575B2 (en) 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
WO2006122311A2 (en) 2005-05-11 2006-11-16 The Trustees Of The University Of Pennsylvania Microfluidic chip
US20070036026A1 (en) 2005-05-16 2007-02-15 Laibinis Paul E Magnetic Particle Systems and Methods
AR054363A1 (es) 2005-05-23 2007-06-20 Astrazeneca Ab Compuestos que exhiben actividad moduladora en el receptor 5-hidroxi-triptamina 6
CA2614180A1 (en) 2005-07-06 2007-01-11 The Regents Of The University Of California Apparatuses, systems, and methods for isolating and separating biological materials
US20070054293A1 (en) 2005-08-30 2007-03-08 California Institute Of Technology Microfluidic chaotic mixing systems and methods
US7611673B2 (en) 2005-09-28 2009-11-03 California Institute Of Technology PMDS microfluidic components and methods of operation of the same
JP4682008B2 (ja) 2005-10-04 2011-05-11 キヤノン株式会社 生化学処理装置、これに用いる容器および検査装置
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US8337755B2 (en) 2006-03-13 2012-12-25 Veridex, Llc Operator independent programmable sample preparation and analysis system
US7892493B2 (en) 2006-05-01 2011-02-22 Koninklijke Philips Electronics N.V. Fluid sample transport device with reduced dead volume for processing, controlling and/or detecting a fluid sample
US8232091B2 (en) 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
WO2007139742A1 (en) 2006-05-22 2007-12-06 Biovest International Inc. Method and system for the production of cells and cell products and applications thereof
WO2007149696A1 (en) 2006-06-23 2007-12-27 Applera Corporation Systems and methods for cooling in biological analysis instruments
US7888107B2 (en) 2006-07-24 2011-02-15 Nanosphere, Inc. System using self-contained processing module for detecting nucleic acids
GB0618966D0 (en) 2006-09-26 2006-11-08 Iti Scotland Ltd Cartridge system
WO2008055257A2 (en) 2006-11-02 2008-05-08 Vectrant Technologies Inc. Cartridge for conducting diagnostic assays
WO2008057375A2 (en) 2006-11-03 2008-05-15 Siemens Healthcare Diagnostics Inc. Random access system and method for polymerase chain reaction testing
WO2008101196A1 (en) 2007-02-15 2008-08-21 Osmetech Molecular Diagnostics Fluidics devices
US20090011417A1 (en) * 2007-03-07 2009-01-08 George Maltezos Testing Device
CN101541962A (zh) * 2007-03-23 2009-09-23 株式会社东芝 核酸检测盒以及核酸检测装置
CN101970111B (zh) * 2007-06-21 2013-09-11 简·探针公司 用于执行处理的仪器和容器
JP2011505011A (ja) 2007-11-28 2011-02-17 スマート チューブ，インコーポレイテッド 生体試料の採取、刺激、安定化及び分析のためのデバイス、システム及び方法
US9409166B2 (en) 2007-12-10 2016-08-09 The Trustees Of The University Of Pennsylvania Integrated PCR reactor for cell lysis, nucleic acid isolation and purification, and nucleic acid amplication related applications
US20090186344A1 (en) 2008-01-23 2009-07-23 Caliper Life Sciences, Inc. Devices and methods for detecting and quantitating nucleic acids using size separation of amplicons
JP2011513712A (ja) 2008-02-21 2011-04-28 アヴァントラ バイオサイエンスィズ コーポレーション アレイ上の液体流に基づく検定
WO2010132834A1 (en) 2009-05-14 2010-11-18 Icubate, Inc. Apparatus for performing amplicon rescue multiplex pcr
EP2438154A1 (en) * 2009-06-02 2012-04-11 Integenx Inc. Fluidic devices with diaphragm valves
CN101718698B (zh) * 2009-11-20 2011-08-17 宁波基内生物技术有限公司 Pcr-ce联用微流控芯片激光诱导荧光分析仪
BR112012021202B1 (pt) 2010-02-23 2020-06-09 Genturadx Usa Inc aparelho e métodos para preparação, reação e detecção integradas de amostras

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US9931636B2 (en) 2018-04-03
CA2834790C (en) 2019-04-09
CA2834790A1 (en) 2012-11-08
AU2016200193A1 (en) 2016-02-04
US20120288897A1 (en) 2012-11-15
EP3081301A1 (en) 2016-10-19
EP2705130A2 (en) 2014-03-12
EP2705130B1 (en) 2016-07-06
HK1244835A1 (zh) 2018-08-17
CN104023834A (zh) 2014-09-03
AU2012250619A1 (en) 2013-11-14
AU2016200193B2 (en) 2018-05-10

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