HK1199447A1 - Process for the crystallisation of cefadroxil - Google Patents

Process for the crystallisation of cefadroxil

Info

Publication number
HK1199447A1
HK1199447A1 HK14113022.9A HK14113022A HK1199447A1 HK 1199447 A1 HK1199447 A1 HK 1199447A1 HK 14113022 A HK14113022 A HK 14113022A HK 1199447 A1 HK1199447 A1 HK 1199447A1
Authority
HK
Hong Kong
Prior art keywords
cefadroxil
crystallisation
Prior art date
Application number
HK14113022.9A
Other languages
English (en)
Chinese (zh)
Inventor
卡洛斯．恩利奎．倫哈特
哈羅德．莫洛．穆迪
西奧多瑞斯．約翰內斯．格德弗里德．瑪麗亞．杜勒恩．范
Original Assignee
Dsm Sinochem Pharm Nl Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Sinochem Pharm Nl Bv filed Critical Dsm Sinochem Pharm Nl Bv
Publication of HK1199447A1 publication Critical patent/HK1199447A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK14113022.9A 2006-05-19 2014-12-29 Process for the crystallisation of cefadroxil HK1199447A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06114240 2006-05-19

Publications (1)

Publication Number Publication Date
HK1199447A1 true HK1199447A1 (en) 2015-07-03

Family

ID=37309255

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14113022.9A HK1199447A1 (en) 2006-05-19 2014-12-29 Process for the crystallisation of cefadroxil

Country Status (10)

Country Link
US (2) US8420806B2 (de)
EP (2) EP2024374A1 (de)
JP (1) JP2009537589A (de)
KR (1) KR101420451B1 (de)
CN (2) CN102351884B (de)
BR (1) BRPI0711924B1 (de)
ES (1) ES2609633T3 (de)
HK (1) HK1199447A1 (de)
MX (1) MX2008014711A (de)
WO (1) WO2007134987A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102134250B (zh) * 2011-01-19 2013-03-13 天津大学 一种头孢羟氨苄单水合物的结晶方法及结晶
CN102268019B (zh) * 2011-07-15 2013-07-10 海南美大制药有限公司 一种头孢羟氨苄化合物及其制法
CN104447795B (zh) * 2014-11-28 2016-08-17 珠海金鸿药业股份有限公司 一种头孢羟氨苄化合物及其药物组合物
CN105534937B (zh) * 2015-12-30 2019-12-03 石药集团欧意药业有限公司 一种头孢羟氨苄片剂及其制备方法
CN106588954B (zh) * 2016-11-08 2018-11-27 山东罗欣药业集团恒欣药业有限公司 一种抗感染药物羟氨苄晶体化合物及其组合物
CN106588953B (zh) * 2016-11-08 2018-11-27 山东罗欣药业集团恒欣药业有限公司 一种抗感染药物头孢羟氨苄晶型化合物及其组合物
AU2018273904A1 (en) * 2017-05-26 2019-11-28 Corteva Agriscience Llc Pyrazole amine reactive crystallization

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3489750A (en) * 1967-09-05 1970-01-13 Bristol Myers Co 7-amino-cephalosporanic and decephalosporanic acid derivatives
US3781282A (en) * 1971-01-20 1973-12-25 W Garbrecht Cephalosporin process and product
US3985741A (en) * 1972-09-15 1976-10-12 Bristol-Myers Company Production of p-hydroxycephalexin
US4091215A (en) 1974-06-05 1978-05-23 Bristol-Myers Company 7-D-α-Amino-.alpha.-(p-acetoxyphenyl)acetamido-3-methyl-3-cephem-4-carboxylic acid
GB1532682A (en) * 1976-04-27 1978-11-22 Bristol Myers Co Process for the preparation of cephadroxil
US4160863A (en) * 1977-04-07 1979-07-10 Bristol-Myers Company Process for the preparation of the crystalline monohydrate of 7-[D-α-aα-(p-hydroxyphenyl)acetamido]-3-methyl-3-cephem-4-carboxylic acid
US4223135A (en) 1979-03-19 1980-09-16 Bristol-Myers Company Production of cephalosporins
GB8714180D0 (en) 1987-06-17 1987-07-22 Rifar Srl Anhydrous crystalline cefadroxil
US4904776A (en) * 1987-04-24 1990-02-27 Rifar S.R.L. Method for producing crystalline cefadroxil hemihydrate
US4898938A (en) * 1987-08-03 1990-02-06 Rifar S.R.L. Method for preparing crystalline cefadroxil monohydrate
ES2010288A6 (es) * 1988-07-08 1989-11-01 Gema Sa Procedimiento para la obtencion de un pseudopolimorfo de cefadroxilo.
GB2240102B (en) * 1990-01-22 1993-10-20 Biochemie Gmbh Improvements in or relating to beta lactam production
ZA915142B (en) 1990-07-04 1992-05-27 Novo Nordisk As Process for preparation of beta-lactams
CN1095875C (zh) 1994-07-18 2002-12-11 吉斯特·布罗卡迪斯股份有限公司 在恒定的高反应物浓度下制备β－内酰胺的方法
KR100455252B1 (ko) * 1995-12-08 2005-01-15 디에스엠 기스트 베.파우. 항생제제조방법
NL1007302C2 (nl) * 1997-10-17 1999-04-20 Dsm Nv Werkwijze voor de bereiding van een ß-lactam antibioticum.
WO1999024441A1 (en) 1997-11-10 1999-05-20 Dsm N.V. Crystallization of beta-lactam compounds
PE20000879A1 (es) * 1998-04-29 2000-09-23 Dsm Nv METODO PARA CRISTALIZAR UN ANTIBIOTICO ß-LACTAMICO
US20040077849A1 (en) 2002-10-16 2004-04-22 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefadroxil
US8420846B2 (en) * 2008-08-25 2013-04-16 Jubilant Life Sciences Limited Process for producing (S)-3-[(1-dimethylamino)ethyl] phenyl-N-ethyl-N-methyl-carbamate via novel intermediates

Also Published As

Publication number Publication date
US20100010213A1 (en) 2010-01-14
BRPI0711924B1 (pt) 2023-11-28
JP2009537589A (ja) 2009-10-29
KR101420451B1 (ko) 2014-07-16
MX2008014711A (es) 2008-12-03
BRPI0711924A2 (pt) 2012-02-22
US20130217659A1 (en) 2013-08-22
CN102351884B (zh) 2015-06-17
CN102351884A (zh) 2012-02-15
KR20090010065A (ko) 2009-01-28
EP2754663A1 (de) 2014-07-16
ES2609633T3 (es) 2017-04-21
BRPI0711924A8 (pt) 2018-12-11
CN101448842A (zh) 2009-06-03
WO2007134987A1 (en) 2007-11-29
EP2024374A1 (de) 2009-02-18
EP2754663B1 (de) 2016-10-12
US8420806B2 (en) 2013-04-16

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20210505