HK1168791A1 - 取代的咪唑並喹喔啉 - Google Patents

取代的咪唑並喹喔啉

Info

Publication number
HK1168791A1
HK1168791A1 HK12109599.2A HK12109599A HK1168791A1 HK 1168791 A1 HK1168791 A1 HK 1168791A1 HK 12109599 A HK12109599 A HK 12109599A HK 1168791 A1 HK1168791 A1 HK 1168791A1
Authority
HK
Hong Kong
Prior art keywords
imidazoquinoxalines
substituted
substituted imidazoquinoxalines
Prior art date
Application number
HK12109599.2A
Other languages
English (en)
Inventor
．科皮茨
．巴德爾
．伯默
．克雷夫特
．利瑙
．馬奈特
．普雷希特爾
．西邁斯特
．韋格沙伊德-格拉赫
Original Assignee
拜耳醫藥股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 拜耳醫藥股份有限公司 filed Critical 拜耳醫藥股份有限公司
Publication of HK1168791A1 publication Critical patent/HK1168791A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK12109599.2A 2009-04-29 2012-09-28 取代的咪唑並喹喔啉 HK1168791A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09159045 2009-04-29
PCT/EP2010/002543 WO2010124826A1 (en) 2009-04-29 2010-04-24 Substituted imidazoquinoxalines

Publications (1)

Publication Number Publication Date
HK1168791A1 true HK1168791A1 (zh) 2013-01-11

Family

ID=42313567

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12109599.2A HK1168791A1 (zh) 2009-04-29 2012-09-28 取代的咪唑並喹喔啉

Country Status (8)

Country Link
US (1) US8729082B2 (zh)
EP (1) EP2424537B1 (zh)
JP (1) JP6168773B2 (zh)
CN (1) CN102413831B (zh)
CA (1) CA2760077A1 (zh)
ES (1) ES2547328T3 (zh)
HK (1) HK1168791A1 (zh)
WO (1) WO2010124826A1 (zh)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2343297A1 (en) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines
EP2343294A1 (en) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Substituted triazolopyridines
TWI535442B (zh) 2010-05-10 2016-06-01 Kyowa Hakko Kirin Co Ltd A nitrogen-containing heterocyclic compound having an action of inhibiting the production of canine erythritine
CA2801031A1 (en) 2010-06-01 2011-12-08 Bayer Intellectual Property Gmbh Substituted imidazopyrazines
UY33452A (es) 2010-06-16 2012-01-31 Bayer Schering Pharma Ag Triazolopiridinas sustituidas
TWI541243B (zh) 2010-09-10 2016-07-11 拜耳知識產權公司 經取代咪唑并嗒
KR101567610B1 (ko) 2010-11-04 2015-11-09 주식회사 엘지화학 신규한 질소 함유 헤테로환 화합물 및 이를 이용한 유기 전자 소자
EP2651945A1 (en) 2010-12-17 2013-10-23 Bayer Intellectual Property GmbH 6-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
EP2651950A1 (en) * 2010-12-17 2013-10-23 Bayer Intellectual Property GmbH 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
CN103443100B (zh) * 2010-12-17 2016-03-23 拜耳知识产权有限责任公司 在过度增殖性病症的治疗中用作mps-1和tkk抑制剂的取代的6-咪唑并吡嗪
EP2651947B1 (en) 2010-12-17 2014-12-10 Bayer Intellectual Property GmbH 6-thio-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
CN103370322B (zh) * 2010-12-17 2016-02-10 拜耳知识产权有限责任公司 在过度增殖性病症的治疗中用作mps-1和tkk抑制剂的2-取代的咪唑并吡嗪
EP2651948A1 (en) 2010-12-17 2013-10-23 Bayer Intellectual Property GmbH Imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment hyperproliferative disorders
CA2831710A1 (en) 2011-03-31 2012-10-04 Bayer Intellectual Property Gmbh Substituted benzimidazoles as mps-1 kinase inhibitors
US20140255392A1 (en) 2011-04-06 2014-09-11 Bayer Intellectual Property Gmbh Substituted imidazopyridines and intermediates thereof
RS54044B1 (en) 2011-04-21 2015-10-30 Bayer Intellectual Property Gmbh TRIAZOLOPIRIDINI
WO2012160029A1 (en) 2011-05-23 2012-11-29 Bayer Intellectual Property Gmbh Substituted triazolopyridines
EP2781517B1 (en) 2011-11-09 2017-10-11 Kyowa Hakko Kirin Co., Ltd. Nitrogen-containing heterocyclic compound
UA112096C2 (uk) 2011-12-12 2016-07-25 Байєр Інтеллектуал Проперті Гмбх Заміщені триазолопіридини та їх застосування як інгібіторів ttk
US9512126B2 (en) 2012-03-14 2016-12-06 Bayer Intellectual Property Gmbh Substituted imidazopyridazines
EA027544B1 (ru) 2012-07-10 2017-08-31 Байер Фарма Акциенгезельшафт Способ получения замещенных триазолопиридинов
WO2014020043A1 (en) 2012-08-02 2014-02-06 Bayer Pharma Aktiengesellschaft Combinations for the treatment of cancer
WO2014020041A1 (en) 2012-08-02 2014-02-06 Bayer Pharma Aktiengesellschaft Combinations for the treatment of cancer
IL312316A (en) * 2012-09-26 2024-06-01 Aragon Pharmaceuticals Inc Antiandrogens for the treatment of castration-resistant prostate cancer without metastases
WO2014195274A1 (en) * 2013-06-07 2014-12-11 Bayer Pharma Aktiengesellschaft Substituted triazolopyridines
PL3008062T3 (pl) 2013-06-11 2017-08-31 Bayer Pharma Aktiengesellschaft Pochodne proleki podstawionych triazolopirydyn
FR3031105B1 (fr) * 2014-12-31 2018-04-06 Universite De Montpellier Nouveaux imidazo[1,2-a]quinoxalines et derives pour le traitement des cancers
CA2981844A1 (en) 2015-04-17 2016-10-20 Netherlands Translational Research Center B.V. Prognostic biomarkers for ttk inhibitor chemotherapy
WO2017037604A1 (en) * 2015-08-28 2017-03-09 Bheema Rao Paraselli Novel fyn kinase inhibitors
GB201522532D0 (en) * 2015-12-21 2016-02-03 Cancer Rec Tech Ltd Novel pyrrolo[3,2-c]pyridine-6-amino derivatives
CN110698418B (zh) * 2019-09-11 2022-07-01 广西师范大学 一种3-芳胺基喹喔啉-2-甲酰胺类衍生物及其制备方法和应用
WO2021169958A1 (zh) * 2020-02-24 2021-09-02 苏州欧康维视生物科技有限公司 作为Syk和VEGFR2双靶点抑制剂的1H-吡唑衍生物及应用
EP4286386A1 (en) * 2021-02-03 2023-12-06 Ocumension Therapeutics (Suzhou) Co., Ltd. Salt form and crystal form of pyrazole substituted imidazo[1,2- a]quinoxaline derivative
CN114621232B (zh) * 2022-03-31 2023-03-14 苏州欧康维视生物科技有限公司 一种Syk和VEGFR2双靶点抑制剂的制备方法及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1972629A1 (en) * 2007-03-23 2008-09-24 Mutabilis SA New imidazolo-heteroaryl derivatives with antibacterial properties
FR2921927B1 (fr) * 2007-10-03 2012-10-12 Univ De Montpellier 1 Imidazo°1,2-a!quinoxalines et derives pour le traitement des cancers

Also Published As

Publication number Publication date
JP2012525343A (ja) 2012-10-22
US8729082B2 (en) 2014-05-20
EP2424537A1 (en) 2012-03-07
CA2760077A1 (en) 2010-11-04
CN102413831B (zh) 2014-06-04
WO2010124826A1 (en) 2010-11-04
CN102413831A (zh) 2012-04-11
EP2424537B1 (en) 2015-07-08
JP6168773B2 (ja) 2017-07-26
US20120128662A1 (en) 2012-05-24
ES2547328T3 (es) 2015-10-05

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20180424