HK1166645A1 - Enzymatic synthesis of carba-nad carba-nad - Google Patents

Enzymatic synthesis of carba-nad carba-nad

Info

Publication number
HK1166645A1
HK1166645A1 HK12107334.6A HK12107334A HK1166645A1 HK 1166645 A1 HK1166645 A1 HK 1166645A1 HK 12107334 A HK12107334 A HK 12107334A HK 1166645 A1 HK1166645 A1 HK 1166645A1
Authority
HK
Hong Kong
Prior art keywords
carba
nad
enzymatic synthesis
enzymatic
synthesis
Prior art date
Application number
HK12107334.6A
Other languages
English (en)
Chinese (zh)
Inventor
Hartmut Duefel
Dieter Heindl
Carina Horn
Thomas Meier
Rainer Schmuck
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1166645A1 publication Critical patent/HK1166645A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/20Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/30Nucleotides
    • C12P19/32Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
HK12107334.6A 2009-07-27 2012-07-25 Enzymatic synthesis of carba-nad carba-nad HK1166645A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09166457 2009-07-27
PCT/EP2010/004523 WO2011012270A1 (fr) 2009-07-27 2010-07-23 Synthèse enzymatique de carba-nad

Publications (1)

Publication Number Publication Date
HK1166645A1 true HK1166645A1 (en) 2012-11-02

Family

ID=41412946

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12107334.6A HK1166645A1 (en) 2009-07-27 2012-07-25 Enzymatic synthesis of carba-nad carba-nad

Country Status (8)

Country Link
US (2) US8580949B2 (fr)
EP (1) EP2459728B1 (fr)
JP (1) JP5540096B2 (fr)
CN (1) CN102471793B (fr)
CA (1) CA2769155C (fr)
ES (1) ES2425631T3 (fr)
HK (1) HK1166645A1 (fr)
WO (1) WO2011012270A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5540096B2 (ja) * 2009-07-27 2014-07-02 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト カルバ−nadの酵素合成
WO2012101095A1 (fr) * 2011-01-26 2012-08-02 Roche Diagnostics Gmbh Procédé et substances permettant de préparer des composés de pyridinium n-substitués
CN102605026B (zh) * 2012-03-06 2013-04-17 苏州汉酶生物技术有限公司 一种氧化型辅酶i的制备方法
CN102605027B (zh) * 2012-03-06 2013-04-17 苏州汉酶生物技术有限公司 一种氧化型辅酶ii的酶催化制备方法
CN103233051B (zh) * 2012-12-19 2016-01-27 浙江嘉华化工有限公司 一种化学生物合成法规模化制备尼克酰胺腺嘌呤二核苷酸的方法
PL2936124T3 (pl) 2012-12-20 2017-08-31 F.Hoffmann-La Roche Ag Sposoby oceniania medycznych krzywych pomiarowych
KR101750638B1 (ko) 2012-12-20 2017-06-23 에프. 호프만-라 로슈 아게 체액의 샘플을 분석하는 방법
EP2781919A1 (fr) 2013-03-19 2014-09-24 Roche Diagniostics GmbH Procédé/dispositif permettant de générer une valeur corrigée de concentration d'un analyte dans un échantillon d'un fluide corporel
JP2016528175A (ja) 2013-06-04 2016-09-15 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Fretに有用な新規化合物およびそれに関連する方法
CN106884028B (zh) * 2015-12-16 2020-10-16 中国科学院大连化学物理研究所 酶促合成烟酰胺尿嘧啶二核苷酸的方法
CN106884029B (zh) * 2015-12-16 2020-10-30 中国科学院大连化学物理研究所 酶促合成烟酰胺胞嘧啶二核苷酸的方法
WO2017109003A1 (fr) 2015-12-21 2017-06-29 F. Hoffmann-La Roche Ag 3-hydroxybutyrate déshydrogénase mutant issu d'alcaligènes faecalis ainsi que des procédés et utilisations les impliquant
CN108473966A (zh) 2016-02-09 2018-08-31 豪夫迈·罗氏有限公司 来自类球红细菌的突变体3-羟基丁酸脱氢酶及其相关方法和用途
WO2018067235A1 (fr) 2016-10-05 2018-04-12 Roche Diabetes Care, Inc. Réactifs de détection et agencements d'électrodes pour éléments de test de diagnostic multi-analytes, ainsi que leurs procédés d'utilisation
EP3339431A1 (fr) 2016-12-22 2018-06-27 Roche Diabetes Care GmbH Variantes de glucose déshydrogénase à propriétés améliorées
WO2019166394A1 (fr) 2018-02-28 2019-09-06 F. Hoffmann-La Roche Ag Revêtement de biocompatibilité pour la mesure continue d'analytes
WO2020258111A1 (fr) * 2019-06-27 2020-12-30 邦泰合盛生物科技(深圳)有限公司 Procédé enzymatique pour la production industrielle de nad
WO2020258110A1 (fr) * 2019-06-27 2020-12-30 邦泰合盛生物科技(深圳)有限公司 Nad synthétase recombinante et gène et leur utilisation
CN111424064A (zh) * 2020-04-20 2020-07-17 比瑞博生物科技(北京)有限公司 一种基于酶法的高纯度nmn制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005035461A1 (de) * 2005-07-28 2007-02-15 Roche Diagnostics Gmbh Stabile NAD/NADH-Derivate
JP2010215488A (ja) * 2009-02-17 2010-09-30 Sumitomo Chemical Co Ltd チタン酸アルミニウム系セラミックス
EP2398909B1 (fr) * 2009-02-19 2015-07-22 F. Hoffmann-La Roche AG Cinétique réactionnelle rapide d'enzymes présentant une activité inférieure dans des couches chimiques sèches
JP5540096B2 (ja) * 2009-07-27 2014-07-02 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト カルバ−nadの酵素合成
EP2292751A1 (fr) * 2009-08-20 2011-03-09 Roche Diagnostics GmbH Stabilisation d'enzymes à l'aide de coenzymes stables
EP2287605A1 (fr) * 2009-08-20 2011-02-23 Roche Diagnostics GmbH Magasinage simplifié de systèmes intégrés

Also Published As

Publication number Publication date
CN102471793B (zh) 2014-04-30
ES2425631T3 (es) 2013-10-16
EP2459728A1 (fr) 2012-06-06
WO2011012270A1 (fr) 2011-02-03
EP2459728B1 (fr) 2013-06-05
JP5540096B2 (ja) 2014-07-02
WO2011012270A8 (fr) 2012-02-23
CA2769155A1 (fr) 2011-02-03
US8580949B2 (en) 2013-11-12
CA2769155C (fr) 2015-04-28
JP2013500026A (ja) 2013-01-07
US20140142291A1 (en) 2014-05-22
CN102471793A (zh) 2012-05-23
US20120130062A1 (en) 2012-05-24

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