HK1164343A1 - 構象動力肽 - Google Patents

構象動力肽

Info

Publication number
HK1164343A1
HK1164343A1 HK12104909.8A HK12104909A HK1164343A1 HK 1164343 A1 HK1164343 A1 HK 1164343A1 HK 12104909 A HK12104909 A HK 12104909A HK 1164343 A1 HK1164343 A1 HK 1164343A1
Authority
HK
Hong Kong
Prior art keywords
conformationally dynamic
peptides
dynamic peptides
conformationally
dynamic
Prior art date
Application number
HK12104909.8A
Other languages
English (en)
Inventor
D Roxanne Duan
Jonathan R Moll
Alan Rudolph
Renee Wegrzyn
Original Assignee
System Of Systems Analytics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by System Of Systems Analytics Inc filed Critical System Of Systems Analytics Inc
Publication of HK1164343A1 publication Critical patent/HK1164343A1/zh

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
HK12104909.8A 2009-01-30 2012-05-18 構象動力肽 HK1164343A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14865909P 2009-01-30 2009-01-30
PCT/US2010/022435 WO2010088411A2 (en) 2009-01-30 2010-01-28 Conformationally dynamic peptides

Publications (1)

Publication Number Publication Date
HK1164343A1 true HK1164343A1 (zh) 2012-09-21

Family

ID=42174089

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12104909.8A HK1164343A1 (zh) 2009-01-30 2012-05-18 構象動力肽

Country Status (9)

Country Link
US (2) US20100233095A1 (zh)
EP (1) EP2391644B1 (zh)
JP (1) JP2012516452A (zh)
CN (1) CN102365295A (zh)
AU (1) AU2010208181B2 (zh)
CA (1) CA2750409C (zh)
HK (1) HK1164343A1 (zh)
MX (1) MX2011007916A (zh)
WO (1) WO2010088411A2 (zh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
MX2009001079A (es) * 2006-07-28 2009-02-10 Adlyfe Inc Sondas de peptido para diagnosis y terapeutica.
AU2010208181B2 (en) 2009-01-30 2015-04-30 Presympto, Inc. Conformationally dynamic peptides
KR20180026562A (ko) 2009-09-22 2018-03-12 메디카고 인코포레이티드 식물-유래 단백질의 제조방법
US20120282169A1 (en) * 2009-11-06 2012-11-08 Adlyfe, Inc. Detection and treatment of traumatic brain injury
US10513539B2 (en) 2011-02-10 2019-12-24 Ruprecht-Karls-Universitat Heidelberg Hydrophobic modified peptides and their use for liver specific targeting
CN103402546B (zh) 2011-02-10 2018-04-13 海德堡鲁普雷希特卡尔斯大学 用于肝特异性诊断的疏水性修饰肽
BR112013022557A2 (pt) * 2011-03-04 2017-08-01 Shire Human Genetic Therapies ligantes de peptídeo composições de polipeptídeo e métodos para uso dos mesmos
US8580922B2 (en) 2011-03-04 2013-11-12 Shire Human Genetic Therapies, Inc. Peptide linkers for polypeptide compositions and methods for using same
TWI620816B (zh) 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
WO2012128722A2 (en) * 2011-03-23 2012-09-27 Agency For Science, Technology And Research Recombinant protein biosensors and a method for detecting the presence of an analyte molecule
CA2834056A1 (en) 2011-04-27 2012-11-01 Adlyfe, Inc. Ocular detection of amyloid proteins
US11435358B2 (en) 2011-06-23 2022-09-06 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
CA2839702C (en) * 2011-06-23 2021-04-20 Board Of Regents, The University Of Texas System Identifying peptides at the single molecule level
WO2013016578A2 (en) * 2011-07-26 2013-01-31 University Of Southern California Controlled release of ocular biopharmaceuticals using bioresponsive protein polymers
EP2746402A1 (en) * 2013-03-12 2014-06-25 Academisch Medisch Centrum Method of prognosis of Alzheimers disease and substrates for use therein
US9588129B2 (en) * 2013-03-15 2017-03-07 Amira Medical Technologies Inc. Methods for analyzing blood to detect diseases associated with abnormal protein aggregation
EP3194980A4 (en) 2014-09-15 2018-07-04 Board of Regents, The University of Texas System Improved single molecule peptide sequencing
WO2016139643A2 (en) * 2015-03-04 2016-09-09 University College Dublin, National University Of Ireland, Dublin Molecular sensors
CN105254655B (zh) * 2015-11-20 2017-03-22 江汉大学 一种基于bodipy的荧光氨基酸及其合成方法与应用
WO2018014025A1 (en) * 2016-07-15 2018-01-18 Ji Hoon Lee Chemiluminescent biosensor for detecting coagulation factors
US11124552B2 (en) 2017-10-25 2021-09-21 Ac Immune Sa Compositions of phosphorylated tau peptides and uses thereof
WO2019134070A1 (en) * 2018-01-02 2019-07-11 Rui Jin Hospital, Shanghai Jiao Tong University School Of Medicine Panda as novel therapeutic
WO2023245057A2 (en) * 2022-06-15 2023-12-21 The Board Of Regents Of The University Of Texas System Structure-based probe for detection of transthyretin amyloid fibrils and aggregates

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565186A (en) 1994-05-13 1996-10-15 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US6448087B1 (en) 1997-12-12 2002-09-10 The Regents Of The University Of California Method for determining and modifying protein/peptide solubility
AU2002314794A1 (en) * 2001-05-23 2002-12-03 New York University Detection of alzheimer's amyloid by magnetic resonance imaging
US7166471B2 (en) * 2001-05-31 2007-01-23 Arete Associates Misfolded protein sensor method in body fluids
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
JP2004173695A (ja) * 2002-11-25 2004-06-24 F Hoffmann La Roche Ag Ｄｐｐ−ｉｖの結晶構造およびその使用方法
JP2004226176A (ja) * 2003-01-21 2004-08-12 Orion Corp ＣＡ−ＡＴＰａｓｅに対するホスホランバン機能を不活化する化合物（ホスホランバン不活性化剤）
JP5414972B2 (ja) * 2003-12-23 2014-02-12 バイオキット， エセ．アー． 病原体感染の検出のための組成物および方法
EP2298807A3 (en) * 2004-07-30 2011-05-18 Rinat Neuroscience Corp. Antibodies directed against amyloid-beta peptide and methods using same
US20060057671A1 (en) 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
US7282373B2 (en) * 2004-12-23 2007-10-16 Rutgers, The State University Of New Jersey Ultra-high specificity fluorescent labeling
JP5048522B2 (ja) * 2005-02-15 2012-10-17 エイディーライフ インコーポレイティッド 誤って折り畳まれたタンパク質およびプリオンを検出する方法
MX2009001079A (es) * 2006-07-28 2009-02-10 Adlyfe Inc Sondas de peptido para diagnosis y terapeutica.
US20090238754A1 (en) * 2008-03-21 2009-09-24 Adlyfe, Inc. Use of pyrene to carry peptides across the blood brain barrier
US20090274621A1 (en) * 2008-03-21 2009-11-05 Adlyfe, Inc Use of pyrene to carry non-peptide agents across the blood brain barrier
AU2010208181B2 (en) 2009-01-30 2015-04-30 Presympto, Inc. Conformationally dynamic peptides
US20120282169A1 (en) * 2009-11-06 2012-11-08 Adlyfe, Inc. Detection and treatment of traumatic brain injury

Also Published As

Publication number Publication date
AU2010208181A1 (en) 2011-08-11
MX2011007916A (es) 2011-11-18
EP2391644A2 (en) 2011-12-07
AU2010208181B2 (en) 2015-04-30
EP2391644B1 (en) 2016-04-13
JP2012516452A (ja) 2012-07-19
CN102365295A (zh) 2012-02-29
CA2750409A1 (en) 2010-08-05
US20100233095A1 (en) 2010-09-16
WO2010088411A3 (en) 2010-09-16
US9696316B2 (en) 2017-07-04
WO2010088411A2 (en) 2010-08-05
CA2750409C (en) 2019-03-05
US20150133632A1 (en) 2015-05-14

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