HK1141829A1 - 水溶液中嗜熱菌蛋白酶的穩定化 - Google Patents

水溶液中嗜熱菌蛋白酶的穩定化

Info

Publication number
HK1141829A1
HK1141829A1 HK10108074.0A HK10108074A HK1141829A1 HK 1141829 A1 HK1141829 A1 HK 1141829A1 HK 10108074 A HK10108074 A HK 10108074A HK 1141829 A1 HK1141829 A1 HK 1141829A1
Authority
HK
Hong Kong
Prior art keywords
thermolysin
stabilization
aqueous solution
aqueous
solution
Prior art date
Application number
HK10108074.0A
Other languages
English (en)
Inventor
Werner Hoelke
Antje Liehre
Johann-Peter Thalhofer
Markus Weber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1141829A1 publication Critical patent/HK1141829A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24027—Thermolysin (3.4.24.27)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK10108074.0A 2008-08-27 2010-08-24 水溶液中嗜熱菌蛋白酶的穩定化 HK1141829A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08015100 2008-08-27

Publications (1)

Publication Number Publication Date
HK1141829A1 true HK1141829A1 (zh) 2010-11-19

Family

ID=39874957

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10108074.0A HK1141829A1 (zh) 2008-08-27 2010-08-24 水溶液中嗜熱菌蛋白酶的穩定化

Country Status (9)

Country Link
US (3) US8211684B2 (zh)
EP (2) EP2607481B1 (zh)
JP (1) JP5634043B2 (zh)
KR (1) KR20100025480A (zh)
CN (1) CN101659950B (zh)
CA (1) CA2676509C (zh)
ES (2) ES2577006T3 (zh)
HK (1) HK1141829A1 (zh)
SG (1) SG159481A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2408909B1 (en) 2009-03-19 2017-11-29 Roche Diagnostics GmbH Improved blends containing proteases
WO2014009276A1 (en) 2012-07-09 2014-01-16 Roche Diagnostics Gmbh Recombinantly produced neutral protease originating from paenibacillus polymyxa
WO2014078581A1 (en) 2012-11-14 2014-05-22 Smith & Nephew, Inc. Stable thermolysin hydrogel
US10202632B2 (en) 2014-05-06 2019-02-12 Diasys Diagnostic Systems Gmbh Enzymatic determination of HbA1c
CN105624140A (zh) * 2016-03-29 2016-06-01 常州大学 一种提高过氧化氢酶存储稳定性的方法
EP3663398A4 (en) * 2017-07-31 2021-05-05 Amano Enzyme Inc. THERMOLYSIN SOLUTION

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0646844A (ja) * 1992-08-03 1994-02-22 Daiwa Kasei Kk 液状酵素剤の製造法
TW306932B (zh) * 1993-08-27 1997-06-01 Holland Sweetener Co
JPH08131170A (ja) * 1994-08-26 1996-05-28 Holland Sweetener Co Vof 酵素の使用、貯蔵及び輸送方法
US6617127B2 (en) * 1998-12-22 2003-09-09 Holland Sweetener Company, V.O.F. Synthesis and recovery of aspartame involving enzymatic deformylation step
US20030078192A1 (en) * 2000-02-03 2003-04-24 Winter Gregory Paul Combinatorial protein domains
JPWO2002085840A1 (ja) * 2001-04-20 2004-08-12 味の素株式会社 Ｎ−ホルミルアミノ酸の製造方法及びその使用
US20030198631A1 (en) 2002-04-18 2003-10-23 Healthpoint, Ltd. Thermolysin enzymatic wound debrider

Also Published As

Publication number Publication date
KR20100025480A (ko) 2010-03-09
US20150337282A1 (en) 2015-11-26
US20120244598A1 (en) 2012-09-27
US9574186B2 (en) 2017-02-21
US8211684B2 (en) 2012-07-03
CA2676509A1 (en) 2010-02-27
US9045743B2 (en) 2015-06-02
EP2161333B1 (en) 2013-11-27
JP5634043B2 (ja) 2014-12-03
JP2010051314A (ja) 2010-03-11
EP2607481A1 (en) 2013-06-26
EP2161333A1 (en) 2010-03-10
ES2577006T3 (es) 2016-07-12
CA2676509C (en) 2017-06-13
SG159481A1 (en) 2010-03-30
EP2607481B1 (en) 2016-04-20
ES2445866T3 (es) 2014-03-05
CN101659950A (zh) 2010-03-03
US20100248326A1 (en) 2010-09-30
CN101659950B (zh) 2014-03-12

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20180825