HK1137415A1 - Positively charged water-soluble prodrugs of mustards and related compounds with very high skin penetration rates - Google Patents
Positively charged water-soluble prodrugs of mustards and related compounds with very high skin penetration ratesInfo
- Publication number
- HK1137415A1 HK1137415A1 HK10100931.0A HK10100931A HK1137415A1 HK 1137415 A1 HK1137415 A1 HK 1137415A1 HK 10100931 A HK10100931 A HK 10100931A HK 1137415 A1 HK1137415 A1 HK 1137415A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- mustards
- positively charged
- related compounds
- skin penetration
- charged water
- Prior art date
Links
- 235000003351 Brassica cretica Nutrition 0.000 title 1
- 235000003343 Brassica rupestris Nutrition 0.000 title 1
- 241000219193 Brassicaceae Species 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 235000010460 mustard Nutrition 0.000 title 1
- 230000035515 penetration Effects 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/242—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyaryl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2429—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of arylalkanols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2006/053619 WO2008041059A1 (en) | 2006-10-03 | 2006-10-03 | Positively charged water-soluble prodrugs of mustards and related compounds with very high skin penetration rates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1137415A1 true HK1137415A1 (en) | 2010-07-30 |
Family
ID=39268129
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK10100931.0A HK1137415A1 (en) | 2006-10-03 | 2010-01-28 | Positively charged water-soluble prodrugs of mustards and related compounds with very high skin penetration rates |
| HK15103662.4A HK1203188A1 (en) | 2006-10-03 | 2015-04-15 | Positively charged water-soluble prodrugs of mustards and related compounds with very high skin penetration rates |
| HK16104109.2A HK1216096A1 (zh) | 2006-10-03 | 2016-04-11 | 具有快速皮膚穿透速度的帶正電荷的水溶性的芥子類化合物及其相關化合物的前藥 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15103662.4A HK1203188A1 (en) | 2006-10-03 | 2015-04-15 | Positively charged water-soluble prodrugs of mustards and related compounds with very high skin penetration rates |
| HK16104109.2A HK1216096A1 (zh) | 2006-10-03 | 2016-04-11 | 具有快速皮膚穿透速度的帶正電荷的水溶性的芥子類化合物及其相關化合物的前藥 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US10189774B2 (xx) |
| EP (2) | EP2792670A1 (xx) |
| CN (1) | CN101511774B (xx) |
| HK (3) | HK1137415A1 (xx) |
| WO (1) | WO2008041059A1 (xx) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| KR101853971B1 (ko) | 2007-06-04 | 2018-05-02 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도 |
| BRPI0922263B1 (pt) * | 2008-12-04 | 2021-08-31 | Chongxi Yu | Composição de alta penetração de um fármaco principal, e seus usos |
| IN2014KN02583A (xx) | 2012-01-18 | 2015-05-08 | Techfields Pharma Co Ltd | |
| MX2015012559A (es) | 2013-03-15 | 2016-07-18 | Techfields Pharma Co Ltd | Novedosos fármacos de alta penetración y sus composiciones para el tratamiento de enfermedades de parkinson. |
| CN108627380B (zh) * | 2017-03-15 | 2020-10-20 | 中国人民解放军军事医学科学院毒物药物研究所 | 去除或减少有毒物质的方法以及检测有毒物质的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091552A (en) | 1986-06-30 | 1992-02-25 | Board Of Regents, The University Of Texas System | Novel antitumor aldophosphamide analogs |
| US5773435A (en) | 1987-08-04 | 1998-06-30 | Bristol-Myers Squibb Company | Prodrugs for β-lactamase and uses thereof |
| EP0569046B1 (en) | 1988-09-06 | 2002-11-13 | Pharmacia Aktiebolag | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| US5691371A (en) | 1993-05-25 | 1997-11-25 | Auckland Uniservices Limited | Nitrobenzyl mustard quaternary salts and their use as hypoxia-selective cytotoxic agents |
| KR100270650B1 (ko) * | 1994-12-23 | 2000-11-01 | 돈 리사 로얄 | 돌연변이된 숙주효소를 이용한 항체-지시된 효소 전구약제 치료 |
| GB9501052D0 (en) | 1995-01-19 | 1995-03-08 | Cancer Res Campaign Tech | Improvements relating to prodrugs |
| US5659061A (en) | 1995-04-20 | 1997-08-19 | Drug Innovation & Design, Inc. | Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities |
| DE19636889A1 (de) * | 1996-09-11 | 1998-03-12 | Felix Dr Kratz | Antineoplastisch wirkende Transferrin- und Albuminkonjugate zytostatischer Verbindungen aus der Gruppe der Anthrazykline, Alkylantien, Antimetabolite und Cisplatin-Analoga und diese enthaltende Arzneimittel |
| US6137003A (en) * | 1998-10-28 | 2000-10-24 | Shionogi Bioresearch | Bis (haloethyl) aminobenzene derivatives |
| GB9907414D0 (en) | 1999-03-31 | 1999-05-26 | Cancer Res Campaign Tech | Improvements relating to prodrugs |
| FR2795412B1 (fr) | 1999-06-23 | 2001-07-13 | Adir | Nouveaux derives d'ammonium quaternaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AU3104301A (en) * | 2000-01-20 | 2001-07-31 | Noven Pharmaceuticals, Inc. | Compositions and methods to effect the release profile in the transdermal administration of active agents |
| GB0102239D0 (en) | 2001-01-29 | 2001-03-14 | Cancer Res Ventures Ltd | Methods of chemical synthisis |
-
2006
- 2006-10-03 EP EP20140156554 patent/EP2792670A1/en active Pending
- 2006-10-03 EP EP06809490.3A patent/EP2077991B1/en not_active Not-in-force
- 2006-10-03 WO PCT/IB2006/053619 patent/WO2008041059A1/en active Search and Examination
- 2006-10-03 CN CN200680056000.7A patent/CN101511774B/zh active Active
-
2009
- 2009-04-03 US US12/418,564 patent/US10189774B2/en not_active Expired - Fee Related
-
2010
- 2010-01-28 HK HK10100931.0A patent/HK1137415A1/xx unknown
-
2015
- 2015-04-15 HK HK15103662.4A patent/HK1203188A1/xx unknown
-
2016
- 2016-04-11 HK HK16104109.2A patent/HK1216096A1/zh unknown
-
2018
- 2018-12-04 US US16/209,744 patent/US11479527B2/en active Active
-
2022
- 2022-10-24 US US18/049,041 patent/US20230097823A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008041059A1 (en) | 2008-04-10 |
| US20230097823A1 (en) | 2023-03-30 |
| US20100069336A1 (en) | 2010-03-18 |
| EP2077991A4 (en) | 2011-11-16 |
| CN101511774B (zh) | 2015-05-13 |
| US11479527B2 (en) | 2022-10-25 |
| EP2077991B1 (en) | 2014-02-26 |
| US20190233367A1 (en) | 2019-08-01 |
| HK1203188A1 (en) | 2015-10-23 |
| HK1216096A1 (zh) | 2016-10-14 |
| CN101511774A (zh) | 2009-08-19 |
| US10189774B2 (en) | 2019-01-29 |
| EP2792670A1 (en) | 2014-10-22 |
| EP2077991A1 (en) | 2009-07-15 |
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