HK1137180A1 - Method for the purification of recombinant blood coagulation factor ix enriched in sulfated and/or phosphorylated molecules - Google Patents

Method for the purification of recombinant blood coagulation factor ix enriched in sulfated and/or phosphorylated molecules

Info

Publication number
HK1137180A1
HK1137180A1 HK10100867.8A HK10100867A HK1137180A1 HK 1137180 A1 HK1137180 A1 HK 1137180A1 HK 10100867 A HK10100867 A HK 10100867A HK 1137180 A1 HK1137180 A1 HK 1137180A1
Authority
HK
Hong Kong
Prior art keywords
sulfated
enriched
purification
blood coagulation
coagulation factor
Prior art date
Application number
HK10100867.8A
Other languages
English (en)
Inventor
Artur Mitterer
Meinhard Hasslacher
Christian Fiedler
Original Assignee
Baxter Int
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int
Publication of HK1137180A1 publication Critical patent/HK1137180A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
HK10100867.8A 2007-02-28 2010-01-27 Method for the purification of recombinant blood coagulation factor ix enriched in sulfated and/or phosphorylated molecules HK1137180A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90400907P 2007-02-28 2007-02-28
PCT/EP2008/001522 WO2008104372A1 (en) 2007-02-28 2008-02-26 Method for the purification of recombinant blood coagulation factor ix enriched in sulfated and/or phosphorylated molecules

Publications (1)

Publication Number Publication Date
HK1137180A1 true HK1137180A1 (en) 2010-07-23

Family

ID=39537538

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10100867.8A HK1137180A1 (en) 2007-02-28 2010-01-27 Method for the purification of recombinant blood coagulation factor ix enriched in sulfated and/or phosphorylated molecules

Country Status (5)

Country Link
US (2) US8399632B2 (xx)
EP (1) EP2125866B1 (xx)
DK (1) DK2125866T3 (xx)
HK (1) HK1137180A1 (xx)
WO (1) WO2008104372A1 (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2544860C2 (ru) * 2008-12-02 2015-03-20 Ново Нордиск Хелс Кеа Аг Очистка полипептидов
CN102639553A (zh) 2009-11-24 2012-08-15 诺沃—诺迪斯克保健股份有限公司 纯化聚乙二醇化蛋白质的方法
WO2011073235A1 (en) * 2009-12-18 2011-06-23 Csl Ltd. Method of purifying polypeptides
KR20120118028A (ko) 2010-01-18 2012-10-25 노보 노르디스크 헬스 케어 악티엔게젤샤프트 혈액 응고 인자의 정제
DK2563805T3 (da) 2010-04-29 2020-05-18 Baxalta GmbH Oprensningsfremgangsmåde til divalente kationbindende proteiner på anionbytningsresin
KR101879885B1 (ko) 2010-09-17 2018-07-18 박스알타 인코퍼레이티드 약산성 내지 중성 ｐｈ에서 히스티딘을 갖는 수성 제형을 통한 면역글로불린의 안정화
WO2012082933A1 (en) * 2010-12-15 2012-06-21 Baxter International, Inc. Eluate collection using conductivity gradient
CN107915769A (zh) 2011-03-29 2018-04-17 葛兰素史密斯克莱有限责任公司 用于蛋白纯化的缓冲液体系
ES2908920T3 (es) * 2011-10-14 2022-05-04 Takeda Pharmaceuticals Co Purificación de proteínas mediante cromatografía de intercambio aniónico
AU2012322949B2 (en) * 2011-10-14 2015-07-02 Takeda Pharmaceutical Company Limited Protein purification by anion exchange chromatography
US10202417B2 (en) * 2013-03-15 2019-02-12 Baxalta Incorporated Purification method for vitamin K dependent proteins by anion exchange chromatography
WO2015200645A1 (en) 2014-06-25 2015-12-30 Jhl Biotech, Inc. Methods and reagents for purification of proteins

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2045167T5 (es) * 1987-10-23 1996-07-01 Centre Regional De Transfusion Preparacion de concentrado de factor ix humano de elevada pureza y de otras proteinas plasmaticas.
US4981952A (en) * 1988-10-04 1991-01-01 Eli Lilly And Company Method for the purification of vitamin K-dependent proteins
DE4406515C1 (de) * 1994-02-28 1995-10-19 Immuno Ag Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine
US5714583A (en) * 1995-06-07 1998-02-03 Genetics Institute, Inc. Factor IX purification methods
JP2001522230A (ja) * 1997-02-14 2001-11-13 アメリカン・レツド・クロス トランスジェニック動物乳房組織における活性ヒト第▲ｉｘ▼因子の発現
EP1991257B1 (en) * 2006-03-07 2015-05-06 Baxter International Inc. Highly phosphorylated and sulfated recombinant factor ix

Also Published As

Publication number Publication date
US20080207879A1 (en) 2008-08-28
US8399632B2 (en) 2013-03-19
US20130150557A1 (en) 2013-06-13
EP2125866B1 (en) 2013-05-22
EP2125866A1 (en) 2009-12-02
DK2125866T3 (da) 2013-07-29
WO2008104372A1 (en) 2008-09-04

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