HK1137180A1 - Method for the purification of recombinant blood coagulation factor ix enriched in sulfated and/or phosphorylated molecules - Google Patents

Method for the purification of recombinant blood coagulation factor ix enriched in sulfated and/or phosphorylated molecules

Info

Publication number
HK1137180A1
HK1137180A1 HK10100867.8A HK10100867A HK1137180A1 HK 1137180 A1 HK1137180 A1 HK 1137180A1 HK 10100867 A HK10100867 A HK 10100867A HK 1137180 A1 HK1137180 A1 HK 1137180A1
Authority
HK
Hong Kong
Prior art keywords
sulfated
enriched
purification
blood coagulation
coagulation factor
Prior art date
Application number
HK10100867.8A
Other languages
English (en)
Inventor
Artur Mitterer
Meinhard Hasslacher
Christian Fiedler
Original Assignee
Baxter Int
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int
Publication of HK1137180A1 publication Critical patent/HK1137180A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
HK10100867.8A 2007-02-28 2010-01-27 Method for the purification of recombinant blood coagulation factor ix enriched in sulfated and/or phosphorylated molecules HK1137180A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90400907P 2007-02-28 2007-02-28
PCT/EP2008/001522 WO2008104372A1 (fr) 2007-02-28 2008-02-26 Méthode de purification du facteur ix de coagulation du sang de recombinaison enrichi en molécules sulfatées et/ou phosphorylées

Publications (1)

Publication Number Publication Date
HK1137180A1 true HK1137180A1 (en) 2010-07-23

Family

ID=39537538

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10100867.8A HK1137180A1 (en) 2007-02-28 2010-01-27 Method for the purification of recombinant blood coagulation factor ix enriched in sulfated and/or phosphorylated molecules

Country Status (5)

Country Link
US (2) US8399632B2 (fr)
EP (1) EP2125866B1 (fr)
DK (1) DK2125866T3 (fr)
HK (1) HK1137180A1 (fr)
WO (1) WO2008104372A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0922716A2 (pt) * 2008-12-02 2016-11-01 Novo Nordisk Healthcare Ag purificação de polipeptídeo
US8697844B2 (en) 2009-11-24 2014-04-15 Novo Nordisk A/S Method of purifying pegylated proteins
KR20120108989A (ko) * 2009-12-18 2012-10-05 시에스엘 리미티드 폴리펩타이드를 정제하는 방법
WO2011086197A1 (fr) 2010-01-18 2011-07-21 Novo Nordisk Health Care Ag Purification de facteurs de coagulation sanguins
NZ603289A (en) * 2010-04-29 2014-07-25 Baxter Int Purification method for divalent cation binding proteins on anion exchange resin
MY188828A (en) 2010-09-17 2022-01-06 Takeda Pharmaceuticals Co Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral ph
US9488625B2 (en) 2010-12-15 2016-11-08 Baxalta GmbH Purification of factor VIII using a conductivity gradient
SG193545A1 (en) 2011-03-29 2013-11-29 Glaxosmithkline Llc Buffer system for protein purification
US10378004B2 (en) * 2011-10-14 2019-08-13 Baxalta GmbH Protein purification by anion exchange chromatography
EP2748180B1 (fr) * 2011-10-14 2018-08-15 Baxalta GmbH Purification de protéines par chromatographie par echange d'anions
SI2970376T1 (sl) * 2013-03-15 2018-09-28 Baxalta Incorporated Metoda čiščenja za vitamin k odvisne proteine z anionsko izmenjevalno kromatografijo
WO2015200645A1 (fr) 2014-06-25 2015-12-30 Jhl Biotech, Inc. Procédés et réactifs destinés à la purification de protéines

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3877529T2 (de) * 1987-10-23 1996-11-07 Centre Regional De Transfusion Herstellung von hoch-gereingtem menschlichen Faktor IX sowie anderem Plasmaproteinkonzentrat und dessen therapeutische Verwendung.
US4981952A (en) 1988-10-04 1991-01-01 Eli Lilly And Company Method for the purification of vitamin K-dependent proteins
DE4406515C1 (de) * 1994-02-28 1995-10-19 Immuno Ag Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine
US5714583A (en) 1995-06-07 1998-02-03 Genetics Institute, Inc. Factor IX purification methods
EP0971724B1 (fr) * 1997-02-14 2010-01-20 American Red Cross Expression du facteur ix humain actif, dans un tissu mammaire d'animal transgenique
WO2007101681A1 (fr) 2006-03-07 2007-09-13 Baxter International Inc Facteur ix recombinant fortement phosphorylé et sulfaté

Also Published As

Publication number Publication date
DK2125866T3 (da) 2013-07-29
US20080207879A1 (en) 2008-08-28
EP2125866A1 (fr) 2009-12-02
US8399632B2 (en) 2013-03-19
WO2008104372A1 (fr) 2008-09-04
EP2125866B1 (fr) 2013-05-22
US20130150557A1 (en) 2013-06-13

Similar Documents

Publication Publication Date Title
HK1137180A1 (en) Method for the purification of recombinant blood coagulation factor ix enriched in sulfated and/or phosphorylated molecules
EP1872811A4 (fr) Instrument d hémodialyse et procédé d hémodialyse
PL2073862T3 (pl) Sposób otrzymywania osocza bogatego w płytki krwi do nieprzetworzonego zastosowania i łączenia jej z komórkami skóry i kości
IL209758A (en) Process for purifying or enriching coagulation factor viii
ZA201101638B (en) Improvements in the absorption of therapeutic agents across mucosal membranes or the skin
EP2361643A4 (fr) Épurateur de sang et son procédé d'amorçage
EP2151273A4 (fr) Membrane à base de polysulfone pour le traitement du sang et procédé de fabrication de celle-ci
NO20081842L (no) Fremgangsmåter og sammensetninger for anvendelse ved behandling av pasienter med autoantistoff-positive sykdommer
HK1142908A1 (en) Pyrazinone derivatives and their use in the treatment of lung diseases
EP1958648A4 (fr) Procede therapeutique visant les troubles de la coagulation sanguine
SG131871A1 (en) Ultrafiltration membranes and methods of making and use of ultrafiltration membranes
EP2503935A4 (fr) Procédé pour la surveillance spectrophotométrique de l'oxygénation du sang d'organes dans le corps
PT2291394T (pt) Proteínas de fusão e seus usos no diagnóstico e tratamento de leishmaniose
IL205562A0 (en) Benzodiazepinone compounds useful in the treatment of skin conditions
HK1170429A1 (en) Alpha aminoamide derivatives useful in the treatment of cognitive disorders
DK1994155T4 (da) Polynukleotid- og polypeptidsekvenser involveret i fremgangsmåden med knogleremodellering
HK1147991A1 (en) Substituted (oxazolidinon-5-yl-methyl) -2-thiophene-carboxamides and use thereof in the field of blood coagulation
IL211459A0 (en) Pancreatic polypeptide and variants thereof for use in the treatment of intestinal disorders
IL194623A (en) Combination of Mazindole for the treatment of ADHD
HK1126861A1 (en) Molecules for the treatment of lung disease involving an immune reaction to connective tissue found in the lung
BR112012006005A2 (pt) "peptídeos no tratamento de transtorno associados ao estresse oxidativo"
IL193306A (en) Use of Enhanced Forms of Factor V in the Preparation of Medicines to Treat Hemostasis-Related Disorders and Isolated Nucleic Acid Molecules Encoded into These Enhanced Forms
GB0816650D0 (en) Therapeutic bone grwth and regeneration
AT504302B8 (de) Verfahren zur herstellung von w-mo-kompositpulvern und kompositpulver
GB0505689D0 (en) Improvements in or relating to the regeneration of water treatment substrates