HK1136770A1 - Histone deacetylase inhibitors with combined activity on class-i and class- iib histone deacetylases in combination with proteasome inhibitors - Google Patents

Histone deacetylase inhibitors with combined activity on class-i and class- iib histone deacetylases in combination with proteasome inhibitors

Info

Publication number
HK1136770A1
HK1136770A1 HK10100549.4A HK10100549A HK1136770A1 HK 1136770 A1 HK1136770 A1 HK 1136770A1 HK 10100549 A HK10100549 A HK 10100549A HK 1136770 A1 HK1136770 A1 HK 1136770A1
Authority
HK
Hong Kong
Prior art keywords
class
inhibitors
combination
histone
iib
Prior art date
Application number
HK10100549.4A
Other languages
English (en)
Inventor
Janine Arts
Peter Willem Jan Hellemans
Michel Marie Francois Janicot
Martin John Page
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1136770A1 publication Critical patent/HK1136770A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
HK10100549.4A 2006-09-15 2010-01-19 Histone deacetylase inhibitors with combined activity on class-i and class- iib histone deacetylases in combination with proteasome inhibitors HK1136770A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06120726 2006-09-15
US91589507P 2007-05-03 2007-05-03
PCT/EP2007/059518 WO2008031817A2 (en) 2006-09-15 2007-09-11 Histone deacetylase inhibitors with combined activity on class-i and class-iib histone deacetylases in combination with proteasome inhibitors

Publications (1)

Publication Number Publication Date
HK1136770A1 true HK1136770A1 (en) 2010-07-09

Family

ID=38824548

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10100549.4A HK1136770A1 (en) 2006-09-15 2010-01-19 Histone deacetylase inhibitors with combined activity on class-i and class- iib histone deacetylases in combination with proteasome inhibitors

Country Status (13)

Country Link
US (1) US20090312284A1 (ru)
EP (1) EP2066327B1 (ru)
JP (1) JP5185274B2 (ru)
KR (1) KR101489947B1 (ru)
AU (1) AU2007296256B2 (ru)
CA (1) CA2659070C (ru)
EA (1) EA020276B1 (ru)
HK (1) HK1136770A1 (ru)
HR (1) HRP20130080T1 (ru)
IL (1) IL197426A (ru)
MX (1) MX2009002925A (ru)
PL (1) PL2066327T3 (ru)
WO (1) WO2008031817A2 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ542445A (en) 2003-04-07 2008-03-28 Pharmacyclics Inc Hydroxamates as therapeutic agents
US8603521B2 (en) 2009-04-17 2013-12-10 Pharmacyclics, Inc. Formulations of histone deacetylase inhibitor and uses thereof
WO2012008514A1 (ja) 2010-07-15 2012-01-19 シャープ株式会社 画像のイントラ予測モード推定装置、画像符号化装置、画像復号装置、及び画像の符号化データ
WO2013021032A1 (en) 2011-08-11 2013-02-14 Janssen Pharmaceutica Nv Histone deacetylase inhibitors in combination with proteasome inhibitors and dexamethasone
SG2014014419A (en) 2011-09-13 2014-07-30 Pharmacyclics Inc Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof
US20150038541A1 (en) * 2012-03-19 2015-02-05 Aposignal Bioscience Llc Composition and methods for cell modulation
TWI649081B (zh) 2013-08-02 2019-02-01 製藥公司 治療固態腫瘤之方法
KR102002581B1 (ko) * 2016-10-04 2019-07-22 주식회사 종근당 혈액암 치료를 위한 hdac 저해제 및 프로테아좀 억제제 또는 면역조절성 약물을 포함하는 약학적 조합물
CN110314222B (zh) * 2019-08-07 2023-05-26 上海交通大学医学院附属瑞金医院 硼替佐米和帕比司他或伏立诺他的组合物在制备治疗耐药型mll白血病的药物中的应用
CN112029738B (zh) * 2020-08-18 2022-04-29 浙江省人民医院 人parkin蛋白乙酰化及其在药物制备中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083903A (en) * 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
PL1781639T3 (pl) * 2004-07-28 2012-07-31 Janssen Pharmaceutica Nv Podstawione pochodne indolilo-alkiloaminowe jako nowe inhibitory deacetylazy histonowej

Also Published As

Publication number Publication date
EA020276B1 (ru) 2014-10-30
CA2659070C (en) 2014-10-21
EP2066327A2 (en) 2009-06-10
EA200970284A1 (ru) 2009-06-30
KR101489947B1 (ko) 2015-02-04
JP5185274B2 (ja) 2013-04-17
US20090312284A1 (en) 2009-12-17
CA2659070A1 (en) 2008-03-20
IL197426A (en) 2014-12-31
PL2066327T3 (pl) 2013-03-29
JP2010503636A (ja) 2010-02-04
KR20090064383A (ko) 2009-06-18
AU2007296256B2 (en) 2013-05-30
HRP20130080T1 (hr) 2013-02-28
IL197426A0 (en) 2009-12-24
WO2008031817A3 (en) 2008-11-20
MX2009002925A (es) 2009-03-31
AU2007296256A1 (en) 2008-03-20
EP2066327B1 (en) 2012-11-14
WO2008031817A2 (en) 2008-03-20

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