HK1136633A1 - Method for identifying the agonistic activity of a target compound on a potassium channel - Google Patents

Method for identifying the agonistic activity of a target compound on a potassium channel

Info

Publication number
HK1136633A1
HK1136633A1 HK10104384.4A HK10104384A HK1136633A1 HK 1136633 A1 HK1136633 A1 HK 1136633A1 HK 10104384 A HK10104384 A HK 10104384A HK 1136633 A1 HK1136633 A1 HK 1136633A1
Authority
HK
Hong Kong
Prior art keywords
identifying
target compound
potassium channel
agonistic activity
agonistic
Prior art date
Application number
HK10104384.4A
Other languages
English (en)
Inventor
Timo Struenker
Markus Cavalar
Gregor Bahrenberg
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of HK1136633A1 publication Critical patent/HK1136633A1/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
HK10104384.4A 2007-03-13 2010-05-04 Method for identifying the agonistic activity of a target compound on a potassium channel HK1136633A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007012029A DE102007012029A1 (de) 2007-03-13 2007-03-13 Verfahren zur Identifizierung der agonistischen Aktivität einer Zielverbindung auf einen Kaliumkanal
PCT/EP2008/001161 WO2008110247A1 (de) 2007-03-13 2008-02-15 Verfahren zur identifizierung der agonistischen aktivität einer zielverbindung auf einen kaliumkanal

Publications (1)

Publication Number Publication Date
HK1136633A1 true HK1136633A1 (en) 2010-07-02

Family

ID=39256928

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10104384.4A HK1136633A1 (en) 2007-03-13 2010-05-04 Method for identifying the agonistic activity of a target compound on a potassium channel

Country Status (8)

Country Link
US (1) US20080227819A1 (xx)
EP (1) EP2122364B1 (xx)
DE (1) DE102007012029A1 (xx)
ES (1) ES2399939T3 (xx)
HK (1) HK1136633A1 (xx)
PL (1) PL2122364T3 (xx)
TW (1) TW200900699A (xx)
WO (1) WO2008110247A1 (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9134307B2 (en) * 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
US8323911B2 (en) * 2010-05-13 2012-12-04 University Of South Carolina High throughput assay for discovering new inhibitors of the GIRK1/4 channel
EP4069226A4 (en) * 2019-12-06 2023-12-27 Icahn School of Medicine at Mount Sinai TREATMENT METHOD WITH KCNQ CHANNEL ACTIVATORS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040175691A1 (en) * 1998-12-03 2004-09-09 Brown Barry S. Use of the KCNQ2 and KCNQ3 genes for the discovery of agents useful in the treatment of neurological disorders
US6329367B1 (en) 1998-12-18 2001-12-11 Novo Nordisk A/S Fused 1,2,4-thiadiazine derivatives, their preparation and use
IL155317A0 (en) * 2000-10-13 2003-11-23 Bristol Myers Squibb Co Methods for detecting modulators of ion channels using thallium (i) sensitive assays
TWI287984B (en) 2000-10-17 2007-10-11 Wyeth Corp Pharmaceutical composition for modulating bladder function
US6852504B2 (en) * 2001-08-08 2005-02-08 Molecular Devices Corporation Method for measuring cellular transmembrane potential changes
WO2005111228A1 (ja) 2004-05-18 2005-11-24 Mitsubishi Pharma Corporation ミトコンドリアの膜電位を変化させる物質の評価方法

Also Published As

Publication number Publication date
DE102007012029A1 (de) 2008-09-18
TW200900699A (en) 2009-01-01
WO2008110247A8 (de) 2008-11-13
PL2122364T3 (pl) 2013-04-30
WO2008110247A1 (de) 2008-09-18
US20080227819A1 (en) 2008-09-18
ES2399939T3 (es) 2013-04-04
EP2122364A1 (de) 2009-11-25
EP2122364B1 (de) 2012-11-21

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20170215