HK1134903A1 - Stereoselective reduction of a morphinone - Google Patents
Stereoselective reduction of a morphinoneInfo
- Publication number
- HK1134903A1 HK1134903A1 HK09111985.5A HK09111985A HK1134903A1 HK 1134903 A1 HK1134903 A1 HK 1134903A1 HK 09111985 A HK09111985 A HK 09111985A HK 1134903 A1 HK1134903 A1 HK 1134903A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- morphinone
- stereoselective reduction
- stereoselective
- reduction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Steroid Compounds (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74533606P | 2006-04-21 | 2006-04-21 | |
PCT/US2007/009761 WO2007124114A2 (en) | 2006-04-21 | 2007-04-19 | Stereoselective reduction of a morphinone |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1134903A1 true HK1134903A1 (en) | 2010-05-20 |
Family
ID=38625648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK09111985.5A HK1134903A1 (en) | 2006-04-21 | 2009-12-21 | Stereoselective reduction of a morphinone |
Country Status (14)
Country | Link |
---|---|
US (2) | US8183376B2 (ja) |
EP (1) | EP2010539B1 (ja) |
JP (1) | JP5586223B2 (ja) |
KR (1) | KR101421747B1 (ja) |
CN (1) | CN101466381B (ja) |
AU (1) | AU2007240680B2 (ja) |
CA (1) | CA2646313C (ja) |
ES (1) | ES2629766T3 (ja) |
HK (1) | HK1134903A1 (ja) |
IL (1) | IL194735A (ja) |
MX (1) | MX2008013594A (ja) |
NZ (1) | NZ572252A (ja) |
WO (1) | WO2007124114A2 (ja) |
ZA (1) | ZA200809258B (ja) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA04003597A (es) | 2001-10-18 | 2004-07-30 | Nektar Therapeutics Al Corp | Conjugados polimericos de antagonistas opiaceos. |
US7786133B2 (en) * | 2003-12-16 | 2010-08-31 | Nektar Therapeutics | Chemically modified small molecules |
US20060182692A1 (en) * | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
AU2009244805B2 (en) * | 2008-05-07 | 2013-01-10 | Nektar Therapeutics | Oral administration of peripherally-acting opioid antagonists |
WO2009155259A1 (en) * | 2008-06-17 | 2009-12-23 | Mallinckrodt Inc. | Processes for the preparation of 6- beta-hydroxy morphinan compounds |
CA2734333A1 (en) * | 2008-09-16 | 2010-03-25 | Nektar Therapeutics | Pegylated opioids with low potential for abuse |
CA2758231A1 (en) | 2009-04-24 | 2010-10-28 | Brock University | Processes for the preparation of morphinane and morphinone compounds |
CA2802294C (en) | 2010-06-11 | 2016-05-10 | Rhodes Technologies | Process for n-dealkylation of tertiary amines |
WO2011154827A2 (en) | 2010-06-11 | 2011-12-15 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
NZ609874A (en) | 2010-09-30 | 2014-10-31 | Astrazeneca Ab | Crystalline naloxol-peg conjugate |
CN103289075B (zh) * | 2012-02-22 | 2016-01-20 | 天津键凯科技有限公司 | 聚乙二醇与纳洛酮的结合物及其药物组合物和应用 |
PT2914599T (pt) | 2012-10-30 | 2018-01-08 | Nektar Therapeutics | Forma de sal sólida de alfa-6-mpeg6-o-hidroxicodona como agonistas opioides e suas utilizações |
US9309256B2 (en) | 2014-04-28 | 2016-04-12 | Orphomed, Inc. | Pharmaceutically active dimers linked through phenolic hydroxyl groups |
US20160067362A1 (en) * | 2014-08-16 | 2016-03-10 | Memorial Sloan Kettering Cancer Center | Helical polycarbodiimide polymers and associated imaging, diagnostic, and therapeutic methods |
CN107033155B (zh) * | 2016-02-04 | 2019-04-26 | 国药集团国瑞药业有限公司 | 一种吗啡酮类化合物的立体选择性还原方法 |
US11077103B2 (en) * | 2016-11-23 | 2021-08-03 | Aurobindo Pharma Ltd. | Naloxegol oxalate and solid dispersion thereof |
CN110305142B (zh) * | 2019-07-12 | 2021-11-16 | 宜昌人福药业有限责任公司 | 一种6β-羟基吗啡衍生物的立体选择性合成方法 |
CN110330500B (zh) * | 2019-07-12 | 2021-11-23 | 宜昌人福药业有限责任公司 | 一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2654756A (en) | 1949-10-20 | 1953-10-06 | Mallinckrodt Chemical Works | Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone |
US2628962A (en) | 1949-10-20 | 1953-02-17 | Mallinckrodt Chemical Works | Method for preparing dihydrocodeinone, dihydromorphinone, and codeinone |
US2715626A (en) | 1950-07-05 | 1955-08-16 | Merck & Co Inc | Process of preparing dihydrocodeinone |
US2649454A (en) | 1951-08-20 | 1953-08-18 | Univ California | Method for preparing dihydromorphinone, dihydrocodeinone, and dihydropseudocodeinone |
US2654746A (en) | 1952-02-13 | 1953-10-06 | Lilly Co Eli | 1-dimethylamino-4-chloro-4-phenylbutane salt of penicillin |
US2806033A (en) | 1955-08-03 | 1957-09-10 | Lewenstein | Morphine derivative |
US3254088A (en) | 1961-03-14 | 1966-05-31 | Lewenstein | Morphine derivative |
US3332950A (en) | 1963-03-23 | 1967-07-25 | Endo Lab | 14-hydroxydihydronormorphinone derivatives |
IL26896A (en) | 1966-01-19 | 1970-11-30 | Endo Lab | 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones |
DE2538075A1 (de) * | 1975-08-27 | 1977-03-17 | Boehringer Sohn Ingelheim | N-tetrahydrofurfuryl-noroxymorphone, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung |
US4089855A (en) * | 1976-04-23 | 1978-05-16 | Cornell Research Foundation, Inc. | Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby |
GB1593191A (en) * | 1977-03-23 | 1981-07-15 | Reckitt & Colmann Prod Ltd | Derivatives of morphine |
US4451470A (en) * | 1982-07-06 | 1984-05-29 | E. I. Du Pont De Nemours And Company | Analgesic, antagonist, and/or anorectic 14-fluoromorphinans |
US5208338A (en) * | 1991-06-14 | 1993-05-04 | The United States Of America As Represented By The Department Of Health & Human Services. | Radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5α-epoxymorphinans |
DE4132159A1 (de) | 1991-09-27 | 1993-04-01 | Boehringer Ingelheim Kg | 14-hydroxy-n-(2-methoxyethyl)-7,8-dihydromorphin und -norisomorphin, verfahren zu deren herstellung und deren verwendung als arzneimittel |
CA2105072C (en) * | 1992-01-23 | 1998-07-28 | Hiroshi Nagase | Morphinan derivative and its pharmaceutical applications |
US5428159A (en) | 1994-04-08 | 1995-06-27 | Ciba-Geigy Corporation | Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine |
ES2127532T3 (es) * | 1994-05-31 | 1999-04-16 | Mallinckrodt Chemical Inc | Preparacion de nalbufina con niveles bajos del epimero beta. |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
MXPA04003597A (es) | 2001-10-18 | 2004-07-30 | Nektar Therapeutics Al Corp | Conjugados polimericos de antagonistas opiaceos. |
US7786133B2 (en) * | 2003-12-16 | 2010-08-31 | Nektar Therapeutics | Chemically modified small molecules |
-
2007
- 2007-04-19 JP JP2009506622A patent/JP5586223B2/ja active Active
- 2007-04-19 CN CN2007800215389A patent/CN101466381B/zh active Active
- 2007-04-19 NZ NZ572252A patent/NZ572252A/en unknown
- 2007-04-19 KR KR1020087028010A patent/KR101421747B1/ko active IP Right Grant
- 2007-04-19 WO PCT/US2007/009761 patent/WO2007124114A2/en active Application Filing
- 2007-04-19 ES ES07755867.4T patent/ES2629766T3/es active Active
- 2007-04-19 US US12/297,632 patent/US8183376B2/en active Active
- 2007-04-19 EP EP07755867.4A patent/EP2010539B1/en active Active
- 2007-04-19 MX MX2008013594A patent/MX2008013594A/es active IP Right Grant
- 2007-04-19 AU AU2007240680A patent/AU2007240680B2/en active Active
- 2007-04-19 CA CA2646313A patent/CA2646313C/en active Active
-
2008
- 2008-10-22 IL IL194735A patent/IL194735A/en active IP Right Grant
- 2008-10-28 ZA ZA200809258A patent/ZA200809258B/xx unknown
-
2009
- 2009-12-21 HK HK09111985.5A patent/HK1134903A1/xx unknown
-
2012
- 2012-04-13 US US13/447,131 patent/US8563726B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2646313C (en) | 2014-05-20 |
WO2007124114A3 (en) | 2008-11-27 |
CN101466381B (zh) | 2012-11-14 |
WO2007124114A2 (en) | 2007-11-01 |
JP2009534393A (ja) | 2009-09-24 |
US8183376B2 (en) | 2012-05-22 |
US8563726B2 (en) | 2013-10-22 |
KR20080110910A (ko) | 2008-12-19 |
AU2007240680A1 (en) | 2007-11-01 |
IL194735A (en) | 2015-09-24 |
US20130018190A1 (en) | 2013-01-17 |
US20090221766A1 (en) | 2009-09-03 |
NZ572252A (en) | 2011-09-30 |
KR101421747B1 (ko) | 2014-07-30 |
IL194735A0 (en) | 2009-08-03 |
ZA200809258B (en) | 2010-08-25 |
AU2007240680B2 (en) | 2013-05-02 |
EP2010539B1 (en) | 2017-06-14 |
CA2646313A1 (en) | 2007-11-01 |
JP5586223B2 (ja) | 2014-09-10 |
EP2010539A2 (en) | 2009-01-07 |
MX2008013594A (es) | 2009-01-16 |
CN101466381A (zh) | 2009-06-24 |
EP2010539A4 (en) | 2010-06-02 |
ES2629766T3 (es) | 2017-08-14 |
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