HK1114882A1 - Retrotransposon inhibition in therapy - Google Patents

Retrotransposon inhibition in therapy

Info

Publication number
HK1114882A1
HK1114882A1 HK08110413.0A HK08110413A HK1114882A1 HK 1114882 A1 HK1114882 A1 HK 1114882A1 HK 08110413 A HK08110413 A HK 08110413A HK 1114882 A1 HK1114882 A1 HK 1114882A1
Authority
HK
Hong Kong
Prior art keywords
retrotransposon
inhibition
therapy
retrotransposon inhibition
Prior art date
Application number
HK08110413.0A
Other languages
English (en)
Inventor
Enrico Garaci
Paola Sinibaldi
Corrado Spadafora
Carmine Pittoggi
Ilaria Sciamanna
Cristina Mearelli
Original Assignee
Ist Superiore Sanita
Enrico Garaci
Paola Sinibaldi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ist Superiore Sanita, Enrico Garaci, Paola Sinibaldi filed Critical Ist Superiore Sanita
Publication of HK1114882A1 publication Critical patent/HK1114882A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK08110413.0A 2004-12-30 2008-09-19 Retrotransposon inhibition in therapy HK1114882A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0428522A GB2421948A (en) 2004-12-30 2004-12-30 Retrotransposon inhibition to treat cancer
PCT/EP2005/014206 WO2006069812A2 (en) 2004-12-30 2005-12-30 Retrotransposon inhibition in therapy

Publications (1)

Publication Number Publication Date
HK1114882A1 true HK1114882A1 (en) 2008-11-14

Family

ID=34179046

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08110413.0A HK1114882A1 (en) 2004-12-30 2008-09-19 Retrotransposon inhibition in therapy

Country Status (9)

Country Link
US (1) US20090203892A1 (xx)
EP (1) EP1836303A2 (xx)
JP (1) JP5442203B2 (xx)
CN (1) CN101151371B (xx)
AU (1) AU2005321407B2 (xx)
CA (1) CA2594245A1 (xx)
GB (1) GB2421948A (xx)
HK (1) HK1114882A1 (xx)
WO (1) WO2006069812A2 (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013375157B2 (en) 2013-01-23 2018-07-12 Alienor Farma Increased dosage of Efavirenz for the treatment of cancer
WO2021076977A1 (en) * 2019-10-16 2021-04-22 King Abdullah University Of Science And Technology Methods for modulating human l1 retrotransposons rna and compositions for use therein
EP3940075A1 (en) * 2020-07-17 2022-01-19 Istituto Nazionale Di Genetica Molecolare-INGM Inhibitors of line1 and uses thereof
CN116157529A (zh) * 2020-12-22 2023-05-23 中国科学院动物研究所 鉴定和/或调节衰老的方法
CN114657281A (zh) * 2020-12-22 2022-06-24 中国科学院动物研究所 内源病毒作为衰老程度的标志物及其作为衰老干预靶标的应用
AU2022272235A1 (en) * 2021-05-11 2023-12-21 Myeloid Therapeutics, Inc. Methods and compositions for genomic integration
CN114107184B (zh) * 2021-11-26 2024-10-22 山东中医药大学第二附属医院 一种siRNA在牙髓干细胞成骨分化中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL360846A1 (en) * 2000-07-06 2004-09-20 Basf Aktiengesellschaft Method for producing bicyclic 1,3-diketones
WO2002062197A2 (en) * 2000-12-19 2002-08-15 Hospital For Special Surgery Markers for disease susceptibility and targets for therapy
US7737124B2 (en) * 2001-09-13 2010-06-15 California Institute Of Technology Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell
US20030203868A1 (en) * 2002-02-06 2003-10-30 Bushman Frederic D. Inhibition of pathogen replication by RNA interference
EP1572956A2 (en) * 2002-08-01 2005-09-14 City of Hope Methods and kits for synthesis of sirna expression cassettes
US20040029275A1 (en) * 2002-08-10 2004-02-12 David Brown Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
US20050113324A1 (en) * 2003-01-15 2005-05-26 Bondarev Igor E. Modulation of line-1 reverse transcriptase
EP1687323A4 (en) * 2003-08-08 2009-08-12 Life Technologies Corp METHODS AND COMPOSITIONS FOR DIRECT CLONING OF NUCLEIC ACID MOLECULES
WO2005089287A2 (en) * 2004-03-15 2005-09-29 City Of Hope Methods and compositions for the specific inhibition of gene expression by double-stranded rna

Also Published As

Publication number Publication date
CN101151371B (zh) 2012-08-08
AU2005321407A1 (en) 2006-07-06
GB2421948A (en) 2006-07-12
US20090203892A1 (en) 2009-08-13
GB0428522D0 (en) 2005-02-09
JP2008526710A (ja) 2008-07-24
CA2594245A1 (en) 2006-07-06
WO2006069812A2 (en) 2006-07-06
AU2005321407B2 (en) 2011-04-07
EP1836303A2 (en) 2007-09-26
WO2006069812A3 (en) 2006-09-14
CN101151371A (zh) 2008-03-26
JP5442203B2 (ja) 2014-03-12

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20161230