HK1108283A1 - Alkil-pyridines as 11-beta inhibitors for diabetes - Google Patents
Alkil-pyridines as 11-beta inhibitors for diabetesInfo
- Publication number
- HK1108283A1 HK1108283A1 HK08102253.0A HK08102253A HK1108283A1 HK 1108283 A1 HK1108283 A1 HK 1108283A1 HK 08102253 A HK08102253 A HK 08102253A HK 1108283 A1 HK1108283 A1 HK 1108283A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- alkil
- pyridines
- diabetes
- beta inhibitors
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04104856 | 2004-10-04 | ||
PCT/EP2005/010372 WO2006037501A1 (en) | 2004-10-04 | 2005-09-26 | Alkil-pyridines as 11-beta inhibitors for diabetes |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1108283A1 true HK1108283A1 (en) | 2008-05-02 |
Family
ID=35276680
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK08102253.0A HK1108283A1 (en) | 2004-10-04 | 2008-02-28 | Alkil-pyridines as 11-beta inhibitors for diabetes |
Country Status (19)
Country | Link |
---|---|
US (1) | US7482341B2 (xx) |
EP (1) | EP1799647A1 (xx) |
JP (2) | JP5414990B2 (xx) |
KR (1) | KR100874313B1 (xx) |
CN (1) | CN101035762B (xx) |
AR (1) | AR054688A1 (xx) |
AU (1) | AU2005291561B2 (xx) |
BR (1) | BRPI0516454A (xx) |
CA (1) | CA2582276C (xx) |
HK (1) | HK1108283A1 (xx) |
IL (1) | IL182310A0 (xx) |
MX (1) | MX2007003913A (xx) |
MY (1) | MY139522A (xx) |
NO (1) | NO20071658L (xx) |
NZ (1) | NZ554014A (xx) |
RU (1) | RU2383533C2 (xx) |
TW (1) | TWI298721B (xx) |
WO (1) | WO2006037501A1 (xx) |
ZA (1) | ZA200702716B (xx) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2582276C (en) * | 2004-10-04 | 2011-09-13 | F. Hoffmann-La Roche Ag | Alkil-pyridines as 11-beta inhibitors for diabetes |
WO2006106423A2 (en) * | 2005-04-07 | 2006-10-12 | Pfizer Inc. | Amino sulfonyl derivatives as inhibitors of human 11-.beta.-hydrosysteroid dehydrogenase |
CN101218235A (zh) * | 2005-05-10 | 2008-07-09 | 沃泰克斯药物股份有限公司 | 作为离子通道调控剂的二环衍生物 |
EA200702498A1 (ru) * | 2005-06-16 | 2008-06-30 | Пфайзер Инк. | N-(пиридин-2-ил)сульфонамидные производные |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
PL2094663T3 (pl) * | 2006-09-21 | 2011-07-29 | Piramal Life Sciences Ltd | Pochodne pirydyny do leczenia zaburzeń matabolicznych związanych z insulinoopornością lub hiperglikemią |
CA2734710A1 (en) * | 2007-08-22 | 2009-02-26 | Proteologics Ltd. | Pyrimidine and pyridine derivatives as posh and posh-ap inhibitors |
US8114868B2 (en) * | 2008-07-25 | 2012-02-14 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
US8871208B2 (en) * | 2009-12-04 | 2014-10-28 | Abbvie Inc. | 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof |
US20130158035A1 (en) * | 2010-08-24 | 2013-06-20 | Brigham Young University | Antimetastatic compounds |
EP2687507B1 (en) * | 2011-03-14 | 2016-03-09 | Taisho Pharmaceutical Co., Ltd. | Nitrogen-containing condensed heterocyclic compound |
TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
CN104974084A (zh) * | 2015-07-19 | 2015-10-14 | 佛山市赛维斯医药科技有限公司 | 一类胺基二吡啶叔醇结构的11β-HSD1抑制剂及其用途 |
TW201811766A (zh) | 2016-08-29 | 2018-04-01 | 瑞士商諾華公司 | N-(吡啶-2-基)吡啶-磺醯胺衍生物及其用於疾病治療之用途 |
RU2652993C1 (ru) * | 2017-06-07 | 2018-05-04 | федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Новое 2-стирилпроизводное 4-(2,6-диметил-4-оксо-5-фенил-4н-пиримидин-1-ил)-бензсульфамида, обладающее эндотелеопротекторной активностью |
EP4361131A1 (en) * | 2021-06-21 | 2024-05-01 | Iregene Therapeutics Ltd | Oct4 high-selectivity activator |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0001899D0 (sv) * | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
CN1633428A (zh) * | 2001-11-22 | 2005-06-29 | 比奥维特罗姆股份公司 | 11-β-羟基类固醇脱氢酶1型抑制剂 |
CA2466491A1 (en) * | 2001-11-22 | 2003-05-30 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
TW200503994A (en) * | 2003-01-24 | 2005-02-01 | Novartis Ag | Organic compounds |
EP1606282B1 (en) * | 2003-02-24 | 2008-11-12 | Arena Pharmaceuticals, Inc. | Phenyl- and pyridylpipereidinye-derivatives as modulators of glucose metabolism |
JPWO2005040135A1 (ja) * | 2003-10-24 | 2007-03-08 | 小野薬品工業株式会社 | 抗ストレス薬およびその医薬用途 |
CN1897944A (zh) * | 2003-12-19 | 2007-01-17 | 辉瑞有限公司 | 用于治疗糖尿病和肥胖症的11-β-羟基类固醇脱氢酶-1型(11-β-HSD-1 ) 抑制剂苯磺酰胺基-吡啶-2-基衍生物和相关化合物 |
OA13344A (en) * | 2003-12-19 | 2007-04-13 | Pfizer | Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 (11-beta-HSD-1) for the treatment of diabetes and obesity. |
CA2582276C (en) * | 2004-10-04 | 2011-09-13 | F. Hoffmann-La Roche Ag | Alkil-pyridines as 11-beta inhibitors for diabetes |
-
2005
- 2005-09-26 CA CA2582276A patent/CA2582276C/en not_active Expired - Fee Related
- 2005-09-26 RU RU2007116431/04A patent/RU2383533C2/ru not_active IP Right Cessation
- 2005-09-26 EP EP05787516A patent/EP1799647A1/en not_active Withdrawn
- 2005-09-26 AU AU2005291561A patent/AU2005291561B2/en not_active Ceased
- 2005-09-26 NZ NZ554014A patent/NZ554014A/en not_active IP Right Cessation
- 2005-09-26 BR BRPI0516454-0A patent/BRPI0516454A/pt not_active IP Right Cessation
- 2005-09-26 CN CN200580033852XA patent/CN101035762B/zh not_active Expired - Fee Related
- 2005-09-26 KR KR1020077007626A patent/KR100874313B1/ko not_active IP Right Cessation
- 2005-09-26 MX MX2007003913A patent/MX2007003913A/es active IP Right Grant
- 2005-09-26 JP JP2007535052A patent/JP5414990B2/ja not_active Expired - Fee Related
- 2005-09-26 WO PCT/EP2005/010372 patent/WO2006037501A1/en active Application Filing
- 2005-09-29 US US11/238,598 patent/US7482341B2/en not_active Expired - Fee Related
- 2005-09-30 TW TW094134144A patent/TWI298721B/zh not_active IP Right Cessation
- 2005-09-30 AR ARP050104148A patent/AR054688A1/es unknown
- 2005-10-03 MY MYPI20054649A patent/MY139522A/en unknown
-
2007
- 2007-03-29 IL IL182310A patent/IL182310A0/en unknown
- 2007-03-29 NO NO20071658A patent/NO20071658L/no not_active Application Discontinuation
- 2007-03-30 ZA ZA200702716A patent/ZA200702716B/xx unknown
-
2008
- 2008-02-28 HK HK08102253.0A patent/HK1108283A1/xx not_active IP Right Cessation
-
2011
- 2011-03-24 JP JP2011065606A patent/JP5351199B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2582276A1 (en) | 2006-04-13 |
AR054688A1 (es) | 2007-07-11 |
US20060074237A1 (en) | 2006-04-06 |
JP2008515826A (ja) | 2008-05-15 |
US7482341B2 (en) | 2009-01-27 |
ZA200702716B (en) | 2008-07-30 |
JP5351199B2 (ja) | 2013-11-27 |
IL182310A0 (en) | 2007-07-24 |
CN101035762A (zh) | 2007-09-12 |
AU2005291561A1 (en) | 2006-04-13 |
WO2006037501A9 (en) | 2007-08-02 |
EP1799647A1 (en) | 2007-06-27 |
RU2007116431A (ru) | 2008-11-10 |
JP2011157373A (ja) | 2011-08-18 |
NZ554014A (en) | 2010-06-25 |
KR100874313B1 (ko) | 2008-12-18 |
CN101035762B (zh) | 2010-09-29 |
KR20070063527A (ko) | 2007-06-19 |
NO20071658L (no) | 2007-05-03 |
CA2582276C (en) | 2011-09-13 |
MX2007003913A (es) | 2007-05-21 |
TWI298721B (en) | 2008-07-11 |
AU2005291561B2 (en) | 2010-02-25 |
MY139522A (en) | 2009-10-30 |
WO2006037501A1 (en) | 2006-04-13 |
RU2383533C2 (ru) | 2010-03-10 |
JP5414990B2 (ja) | 2014-02-12 |
TW200616958A (en) | 2006-06-01 |
BRPI0516454A (pt) | 2008-09-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20140926 |