HK1105689A1 - Pcr elbow determination by use a double sigmoid function curve fit with the levenberg-marquardt and normalization - Google Patents

Pcr elbow determination by use a double sigmoid function curve fit with the levenberg-marquardt and normalization

Info

Publication number
HK1105689A1
HK1105689A1 HK07110781.5A HK07110781A HK1105689A1 HK 1105689 A1 HK1105689 A1 HK 1105689A1 HK 07110781 A HK07110781 A HK 07110781A HK 1105689 A1 HK1105689 A1 HK 1105689A1
Authority
HK
Hong Kong
Prior art keywords
levenberg
marquardt
normalization
sigmoid function
curve fit
Prior art date
Application number
HK07110781.5A
Other languages
English (en)
Inventor
Laurent Francioli
Rolf Knobel
Ronald T Kurnik
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/316,315 external-priority patent/US7668663B2/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1105689A1 publication Critical patent/HK1105689A1/xx

Links

Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G06F17/17—Function evaluation by approximation methods, e.g. inter- or extrapolation, smoothing, least mean square method
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F2218/00—Aspects of pattern recognition specially adapted for signal processing
    • G06F2218/02—Preprocessing
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F2218/00—Aspects of pattern recognition specially adapted for signal processing
    • G06F2218/08—Feature extraction
    • G06F2218/10—Feature extraction by analysing the shape of a waveform, e.g. extracting parameters relating to peaks

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Mathematical Physics (AREA)
  • Data Mining & Analysis (AREA)
  • Theoretical Computer Science (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Analysis (AREA)
  • Pure & Applied Mathematics (AREA)
  • Computational Mathematics (AREA)
  • Algebra (AREA)
  • Databases & Information Systems (AREA)
  • Software Systems (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
HK07110781.5A 2005-12-20 2007-10-04 Pcr elbow determination by use a double sigmoid function curve fit with the levenberg-marquardt and normalization HK1105689A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/316,315 US7668663B2 (en) 2005-12-20 2005-12-20 Levenberg-Marquardt outlier spike removal method
US11/349,550 US7680868B2 (en) 2005-12-20 2006-02-06 PCR elbow determination by use of a double sigmoid function curve fit with the Levenburg-Marquardt algorithm and normalization

Publications (1)

Publication Number Publication Date
HK1105689A1 true HK1105689A1 (en) 2008-02-22

Family

ID=37909665

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07110781.5A HK1105689A1 (en) 2005-12-20 2007-10-04 Pcr elbow determination by use a double sigmoid function curve fit with the levenberg-marquardt and normalization

Country Status (5)

Country Link
US (1) US7680868B2 (de)
EP (1) EP1801706B1 (de)
JP (1) JP4718432B2 (de)
CA (1) CA2571446A1 (de)
HK (1) HK1105689A1 (de)

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US7991558B2 (en) * 2005-09-29 2011-08-02 Roche Molecular Systems, Inc. Systems and methods for determining real-time PCR cycle thresholds using cluster analysis
US7991561B2 (en) * 2005-09-29 2011-08-02 Roche Molecular Systems, Inc. Ct determination by cluster analysis with variable cluster endpoint
US7844403B2 (en) * 2005-12-20 2010-11-30 Roche Molecular Systems, Inc. Temperature step correction with double sigmoid Levenberg-Marquardt and robust linear regression
US7991562B2 (en) * 2005-12-20 2011-08-02 Roche Molecular Systems, Inc. PCR elbow determination using curvature analysis of a double sigmoid
US7668663B2 (en) * 2005-12-20 2010-02-23 Roche Molecular Systems, Inc. Levenberg-Marquardt outlier spike removal method
US8095322B2 (en) * 2007-06-29 2012-01-10 Roche Molecular Systems, Inc. Systems and methods for determining cross-talk coefficients in PCR and other data sets
US20100274511A1 (en) * 2007-09-20 2010-10-28 National University Corporation University Of Toyama Signal analysis method, signal analysis device and signal analysis program
US20090119020A1 (en) * 2007-09-25 2009-05-07 Roche Molecular Systems, Inc. Pcr elbow determination using quadratic test for curvature analysis of a double sigmoid
KR101413659B1 (ko) * 2007-12-06 2014-07-01 삼성전자주식회사 실시간 핵산 증폭 데이터로부터 시료 중의 표적 핵산의초기 농도를 결정하는 방법
KR20110008261A (ko) * 2008-04-24 2011-01-26 쓰리엠 이노베이티브 프로퍼티즈 컴파니 웨이블릿 변환을 사용한 핵산 증폭 곡선의 분석
US8374795B2 (en) * 2008-05-13 2013-02-12 Roche Molecular Systems, Inc. Systems and methods for step discontinuity removal in real-time PCR fluorescence data
US8219324B2 (en) * 2008-09-12 2012-07-10 Roche Molecular Systems, Inc. Real-time PCR elbow calling by equation-less algorithm
WO2010119407A1 (en) 2009-04-16 2010-10-21 Koninklijke Philips Electronics N.V. Methods for nucleic acid quantification
US8265879B2 (en) * 2009-04-17 2012-09-11 Roche Molecular Systems, Inc. Determination of single peak melting temperature by PCR analogy and double sigmoid equation
US8219366B2 (en) * 2009-08-26 2012-07-10 Roche Molecular Sytems, Inc. Determination of elbow values for PCR for parabolic shaped curves
US9938569B2 (en) 2009-09-10 2018-04-10 Diasorin S.P.A. Compensation for spectral crosstalk in multiplex nucleic acid amplification
KR20120098608A (ko) * 2009-09-12 2012-09-05 애주어 볼트 리미티드. 화학 반응내의 천이점 식별 장치 및 방법
US8666673B2 (en) 2010-05-14 2014-03-04 Biomerieux, Inc Identification and/or characterization of a microbial agent using taxonomic hierarchical classification
US8521484B2 (en) * 2010-06-02 2013-08-27 Livermore Software Technology Corp. Curve matching for parameter identification
WO2012123895A1 (en) * 2011-03-15 2012-09-20 Azure Vault Ltd Rate based identification of reaction points
US10176293B2 (en) 2012-10-02 2019-01-08 Roche Molecular Systems, Inc. Universal method to determine real-time PCR cycle threshold values
US9607128B2 (en) * 2013-12-30 2017-03-28 Roche Molecular Systems, Inc. Detection and correction of jumps in real-time PCR signals
EP3688760A4 (de) * 2017-09-28 2021-07-14 Seegene, Inc. Verfahren und vorrichtung zur analyse eines zielanalyten in einer probe
GB201809418D0 (en) * 2018-06-08 2018-07-25 Imperial Innovations Ltd A method for analysis of real-time amplification data
EP3820616A1 (de) * 2018-07-10 2021-05-19 Gen-Probe Incorporated Verfahren und systeme zur detektion und quantifizierung von nukleinsäuren
CN109117449B (zh) * 2018-07-27 2022-04-15 武汉文网亿联科技有限公司 基于非线性最小二乘模型测算网吧安装率的方法
CN112034162B (zh) * 2020-08-31 2023-12-08 成都艾科斯伦医疗科技有限公司 一种光学检测反应曲线优化算法
JP2024522640A (ja) 2021-06-25 2024-06-21 エフ． ホフマン－ラ ロシュ アーゲー 高感度で温度多重化ｐｃｒを行うための方法
CN114058683B (zh) * 2021-11-17 2022-09-30 杭州优思达生物技术有限公司 一种核酸扩增结果判定方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4281877B2 (ja) 1996-06-04 2009-06-17 ユニバーシティ オブ ユタ リサーチ ファウンデーション 生物学的プロセスを実行し且つモニタリングするためのシステムと方法
ATE295427T1 (de) 1996-06-04 2005-05-15 Univ Utah Res Found Überwachung der hybridisierung während pcr
GB9809839D0 (en) * 1998-05-09 1998-07-08 Glaxo Group Ltd Antibody
US7228237B2 (en) * 2002-02-07 2007-06-05 Applera Corporation Automatic threshold setting and baseline determination for real-time PCR
EP1647910A1 (de) * 2004-09-29 2006-04-19 Roche Diagnostics GmbH Qualitative Bestimmung einer Probe mittels eines Algorithmus
US7991561B2 (en) * 2005-09-29 2011-08-02 Roche Molecular Systems, Inc. Ct determination by cluster analysis with variable cluster endpoint
EP1798650A1 (de) * 2005-12-19 2007-06-20 Roche Diagnostics GmbH Analytisches Verfahren und Instrument
US7844403B2 (en) 2005-12-20 2010-11-30 Roche Molecular Systems, Inc. Temperature step correction with double sigmoid Levenberg-Marquardt and robust linear regression
EP1804172B1 (de) * 2005-12-20 2021-08-11 Roche Diagnostics GmbH Bestimmung des Wendepunktes einer PCR-Kurve mittels Krümmungsanalyse einer Doppelsigmoidfunktion
US7991562B2 (en) 2005-12-20 2011-08-02 Roche Molecular Systems, Inc. PCR elbow determination using curvature analysis of a double sigmoid
US7668663B2 (en) 2005-12-20 2010-02-23 Roche Molecular Systems, Inc. Levenberg-Marquardt outlier spike removal method

Also Published As

Publication number Publication date
JP4718432B2 (ja) 2011-07-06
EP1801706B1 (de) 2020-01-15
US7680868B2 (en) 2010-03-16
JP2007193783A (ja) 2007-08-02
CA2571446A1 (en) 2007-06-20
EP1801706A3 (de) 2017-08-09
US20070143385A1 (en) 2007-06-21
EP1801706A2 (de) 2007-06-27

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