HK1080517A1 - Nucleic acid and amino acid sequences encoding high-level expressor factor viii polypeptides and methods of use - Google Patents
Nucleic acid and amino acid sequences encoding high-level expressor factor viii polypeptides and methods of useInfo
- Publication number
- HK1080517A1 HK1080517A1 HK06103163A HK06103163A HK1080517A1 HK 1080517 A1 HK1080517 A1 HK 1080517A1 HK 06103163 A HK06103163 A HK 06103163A HK 06103163 A HK06103163 A HK 06103163A HK 1080517 A1 HK1080517 A1 HK 1080517A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- methods
- factor viii
- amino acid
- nucleic acid
- sequences encoding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32738801P | 2001-10-05 | 2001-10-05 | |
PCT/US2002/033403 WO2003031598A2 (en) | 2001-10-05 | 2002-10-07 | Nucleic acid and amino acid sequences encoding high-level expressor factor viii polypeptides and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1080517A1 true HK1080517A1 (en) | 2006-04-28 |
Family
ID=23276347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK06103163A HK1080517A1 (en) | 2001-10-05 | 2006-03-13 | Nucleic acid and amino acid sequences encoding high-level expressor factor viii polypeptides and methods of use |
Country Status (10)
Country | Link |
---|---|
US (3) | US7635763B2 (xx) |
EP (1) | EP1572889B1 (xx) |
JP (2) | JP4634036B2 (xx) |
AT (1) | ATE417618T1 (xx) |
AU (1) | AU2002337901B2 (xx) |
CA (1) | CA2461443C (xx) |
DE (1) | DE60230456D1 (xx) |
ES (1) | ES2319745T3 (xx) |
HK (1) | HK1080517A1 (xx) |
WO (1) | WO2003031598A2 (xx) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7560107B2 (en) | 1996-06-26 | 2009-07-14 | Emory University | Modified factor VIII |
AU2002337901B2 (en) * | 2001-10-05 | 2008-01-17 | Expression Therapeutics Llc | Nucleic acid and amino acid sequences encoding high-level expressor factor VIII polypeptides and methods of use |
EP1636360A4 (en) | 2003-06-03 | 2006-11-08 | Cell Genesys Inc | COMPOSITIONS AND METHODS FOR ENHANCED EXPRESSION OF RECOMBINANT POLYPEPTIDES FROM A SINGLE VECTOR USING A PEPTIDE CLEAVAGE SITE |
US7485291B2 (en) | 2003-06-03 | 2009-02-03 | Cell Genesys, Inc. | Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof |
SI1750733T1 (sl) | 2004-05-03 | 2014-03-31 | Emory University | POSTOPEK DAJANJA PRAĹ IÄŚJEGA fVIII BREZ DOMENE B |
PL1824988T3 (pl) | 2004-11-12 | 2018-01-31 | Bayer Healthcare Llc | Ukierunkowana na miejsce modyfikacja czynnika VIII |
CA2724630A1 (en) * | 2008-05-16 | 2009-11-19 | Bayer Healthcare Llc | Targeted coagulation factors and method of using the same |
ES2721478T3 (es) * | 2010-11-05 | 2019-07-31 | Baxalta Inc | Nueva variante del factor VIII antihemofílico que tiene actividad específica aumentada |
ES2722209T3 (es) * | 2011-07-08 | 2019-08-08 | Bioverativ Therapeutics Inc | Polipéptidos quiméricos e híbridos del Factor VIII, y métodos de uso de los mismos |
US8986991B2 (en) * | 2012-07-03 | 2015-03-24 | Expression Therapeutics, Llc | High yield suspension cell line, system and method for making same |
EP3904376A1 (en) * | 2013-06-24 | 2021-11-03 | Xiao, Weidong | Mutant factor viii compositions and methods |
US10058624B2 (en) * | 2015-04-16 | 2018-08-28 | Emory University | Recombinant promoters and vectors for protein expression in liver and use thereof |
SG10202106307UA (en) | 2015-11-13 | 2021-07-29 | Takeda Pharmaceuticals Co | Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a |
CN108602876B (zh) | 2015-11-13 | 2022-07-05 | 武田药品工业株式会社 | 用于血友病a的基因治疗的具有增加的表达的编码重组fviii变体的病毒载体 |
MX2018012537A (es) | 2016-04-15 | 2019-02-25 | Univ Pennsylvania | Terapia de genes para tratar hemofilia a. |
EP3672605A1 (en) | 2017-08-23 | 2020-07-01 | Wake Forest University Health Sciences | In utero transplantation of factor viii-expressing cells for treatment of hemophilia |
US20200360441A1 (en) | 2017-08-23 | 2020-11-19 | Wake Forest University Health Sciences | Post-natal transplantation of factor viii-expressing cells for treatment of hemophilia |
TW202039546A (zh) | 2019-01-16 | 2020-11-01 | 美商巴克斯歐塔公司 | 用於a型血友病基因治療之編碼表現增加之重組fviii變異體的病毒載體 |
US11680109B2 (en) | 2019-05-29 | 2023-06-20 | Duke University | Compositions and methods for detection and measurement of RNA modifications through targeted RNA editing |
WO2022165390A1 (en) * | 2021-01-29 | 2022-08-04 | Expression Therapeutics, Llc | Nucleic acid and amino acid sequences encoding high-level expressor factor viii polypeptides and methods of use |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5859204A (en) | 1992-04-07 | 1999-01-12 | Emory University | Modified factor VIII |
US6180371B1 (en) | 1996-06-26 | 2001-01-30 | Emory University | Modified factor VIII |
US5744446A (en) | 1992-04-07 | 1998-04-28 | Emory University | Hybrid human/animal factor VIII |
US6376463B1 (en) | 1992-04-07 | 2002-04-23 | Emory University | Modified factor VIII |
US5364771A (en) | 1992-04-07 | 1994-11-15 | Emory University | Hybrid human/porcine factor VIII |
US5663060A (en) | 1992-04-07 | 1997-09-02 | Emory University | Hybrid human/animal factor VIII |
US5888974A (en) | 1992-04-07 | 1999-03-30 | Emory University | Hybrid human/animal factor VIII |
JPH08511423A (ja) * | 1993-06-10 | 1996-12-03 | ジェネティック セラピー,インコーポレイテッド | 血友病治療のためのアデノウイルスベクター |
US6818439B1 (en) * | 1994-12-30 | 2004-11-16 | Chiron Corporation | Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia and other disorders |
US6458563B1 (en) | 1996-06-26 | 2002-10-01 | Emory University | Modified factor VIII |
JP2002517180A (ja) * | 1997-12-05 | 2002-06-18 | ジ・イミユーン・リスポンス・コーポレーシヨン | 増大された発現を示す新規ベクターおよび遺伝子 |
US6200560B1 (en) * | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
AU2002337901B2 (en) * | 2001-10-05 | 2008-01-17 | Expression Therapeutics Llc | Nucleic acid and amino acid sequences encoding high-level expressor factor VIII polypeptides and methods of use |
-
2002
- 2002-10-07 AU AU2002337901A patent/AU2002337901B2/en not_active Ceased
- 2002-10-07 EP EP02773804A patent/EP1572889B1/en not_active Expired - Lifetime
- 2002-10-07 WO PCT/US2002/033403 patent/WO2003031598A2/en active Search and Examination
- 2002-10-07 AT AT02773804T patent/ATE417618T1/de not_active IP Right Cessation
- 2002-10-07 CA CA2461443A patent/CA2461443C/en not_active Expired - Lifetime
- 2002-10-07 DE DE60230456T patent/DE60230456D1/de not_active Expired - Lifetime
- 2002-10-07 ES ES02773804T patent/ES2319745T3/es not_active Expired - Lifetime
- 2002-10-07 JP JP2003534569A patent/JP4634036B2/ja not_active Expired - Lifetime
-
2004
- 2004-03-30 US US10/813,507 patent/US7635763B2/en active Active
-
2006
- 2006-03-13 HK HK06103163A patent/HK1080517A1/xx not_active IP Right Cessation
-
2009
- 2009-12-11 US US12/636,424 patent/US8188246B2/en not_active Expired - Lifetime
-
2010
- 2010-09-17 JP JP2010210204A patent/JP5162635B2/ja not_active Expired - Lifetime
-
2012
- 2012-05-27 US US13/481,840 patent/US8519111B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2011015698A (ja) | 2011-01-27 |
WO2003031598A3 (en) | 2006-01-05 |
EP1572889B1 (en) | 2008-12-17 |
US7635763B2 (en) | 2009-12-22 |
WO2003031598A2 (en) | 2003-04-17 |
US8519111B2 (en) | 2013-08-27 |
US20110077203A1 (en) | 2011-03-31 |
JP4634036B2 (ja) | 2011-02-16 |
US8188246B2 (en) | 2012-05-29 |
ATE417618T1 (de) | 2009-01-15 |
EP1572889A4 (en) | 2006-09-06 |
US20120270266A1 (en) | 2012-10-25 |
US20050118684A1 (en) | 2005-06-02 |
ES2319745T3 (es) | 2009-05-12 |
CA2461443A1 (en) | 2003-04-17 |
JP2005518783A (ja) | 2005-06-30 |
CA2461443C (en) | 2011-07-12 |
EP1572889A2 (en) | 2005-09-14 |
AU2002337901B2 (en) | 2008-01-17 |
DE60230456D1 (de) | 2009-01-29 |
JP5162635B2 (ja) | 2013-03-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20171007 |