HK1080167A1 - 代谢表型化 - Google Patents

代谢表型化 Download PDF

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Publication number
HK1080167A1
HK1080167A1 HK06100119.0A HK06100119A HK1080167A1 HK 1080167 A1 HK1080167 A1 HK 1080167A1 HK 06100119 A HK06100119 A HK 06100119A HK 1080167 A1 HK1080167 A1 HK 1080167A1
Authority
HK
Hong Kong
Prior art keywords
subject
data
administration
dose
post
Prior art date
Application number
HK06100119.0A
Other languages
English (en)
Chinese (zh)
Inventor
T．A．克莱顿
T．A．克萊頓
J．R．埃弗里特
J．C．林顿
J．R．埃弗裡特
J．K．尼克尔森
J．C．林頓
J．K．尼克爾森
Original Assignee
辉瑞大药厂
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0213786A external-priority patent/GB0213786D0/en
Priority claimed from GB0213895A external-priority patent/GB0213895D0/en
Application filed by 辉瑞大药厂 filed Critical 辉瑞大药厂
Publication of HK1080167A1 publication Critical patent/HK1080167A1/zh

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Saccharide Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
HK06100119.0A 2002-06-14 2003-06-16 代谢表型化 HK1080167A1 (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0213786A GB0213786D0 (en) 2002-06-14 2002-06-14 Metabolic phenotyping
GB1213786.7 2002-06-14
GB0213895.6 2002-06-17
GB0213895A GB0213895D0 (en) 2002-06-17 2002-06-17 Metabolic phenotyping
PCT/IB2003/002309 WO2003107270A2 (en) 2002-06-14 2003-06-16 Metabolic phenotyping

Publications (1)

Publication Number Publication Date
HK1080167A1 true HK1080167A1 (zh) 2006-04-21

Family

ID=29738094

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06100119.0A HK1080167A1 (zh) 2002-06-14 2003-06-16 代谢表型化

Country Status (15)

Country Link
US (2) US20050074745A1 (cg-RX-API-DMAC7.html)
EP (1) EP1540560B1 (cg-RX-API-DMAC7.html)
JP (1) JP4829496B2 (cg-RX-API-DMAC7.html)
KR (1) KR20050012281A (cg-RX-API-DMAC7.html)
AT (1) ATE502343T1 (cg-RX-API-DMAC7.html)
AU (1) AU2003232406A1 (cg-RX-API-DMAC7.html)
CA (1) CA2487836C (cg-RX-API-DMAC7.html)
DE (1) DE60336403D1 (cg-RX-API-DMAC7.html)
HK (1) HK1080167A1 (cg-RX-API-DMAC7.html)
HR (1) HRP20041174A2 (cg-RX-API-DMAC7.html)
IL (1) IL165329A0 (cg-RX-API-DMAC7.html)
IN (1) IN2004DN03762A (cg-RX-API-DMAC7.html)
NO (1) NO20045111L (cg-RX-API-DMAC7.html)
RU (1) RU2004136317A (cg-RX-API-DMAC7.html)
WO (1) WO2003107270A2 (cg-RX-API-DMAC7.html)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040142496A1 (en) * 2001-04-23 2004-07-22 Nicholson Jeremy Kirk Methods for analysis of spectral data and their applications: atherosclerosis/coronary heart disease
US20050037515A1 (en) * 2001-04-23 2005-02-17 Nicholson Jeremy Kirk Methods for analysis of spectral data and their applications osteoporosis
WO2003017177A2 (en) * 2001-08-13 2003-02-27 Beyong Genomics, Inc. Method and system for profiling biological systems
IN2004DN03762A (cg-RX-API-DMAC7.html) 2002-06-14 2010-01-08 Pfizer
WO2005020125A2 (en) * 2003-08-20 2005-03-03 Bg Medicine, Inc. Methods and systems for profiling biological systems
US7534619B2 (en) * 2005-10-27 2009-05-19 Brandon Horn Method for determining metabolic type
US7899625B2 (en) * 2006-07-27 2011-03-01 International Business Machines Corporation Method and system for robust classification strategy for cancer detection from mass spectrometry data
EP2428587A3 (en) * 2006-10-13 2012-07-18 Metabolon Inc. Biomarkers related to metabolic age and methods using the same
US20080286774A1 (en) * 2007-05-16 2008-11-20 The Regents Of The University Of California Real-time individualized therapy evaluation
US20100273203A1 (en) * 2009-04-23 2010-10-28 Board Of Trustees Of The University Of Arkansas Methods and compositions for detecting metabolites
US8660823B2 (en) * 2009-04-26 2014-02-25 Lester F. Ludwig Nonlinear and lie algebra structural analysis system for enzyme cascades, metabolic signal transduction, signaling pathways, catalytic chemical reaction networks, and immunology
GB0912685D0 (en) 2009-07-22 2009-08-26 Imp Innovations Ltd Methods
GB0912744D0 (en) 2009-07-22 2009-08-26 Imp Innovations Ltd Methods and uses
US8410064B2 (en) * 2009-08-24 2013-04-02 The Board Of Trustees Of The University Of Arkansas Classical cannabinoid metabolites and methods of use thereof
US8883218B2 (en) 2010-03-26 2014-11-11 The Board Of Trustees Of The University Of Arkansas Anti-cancer nanoparticle compositions and methods of use
GB201012297D0 (en) * 2010-07-22 2010-09-08 Ge Healthcare Uk Ltd A system and method for automated biological cell assay data analysis
WO2012018535A2 (en) * 2010-07-26 2012-02-09 Wellness Indicators, Inc. Wellness panel
US9095598B2 (en) 2010-12-28 2015-08-04 The Board Of Trustees Of The University Of Arkansas Stilbenoid derivatives and their uses
US9535144B2 (en) 2012-06-01 2017-01-03 Liposcience, Inc. NMR quantification of TMAO
US9470771B2 (en) 2012-06-08 2016-10-18 Liposcience, Inc. NMR measurements of NMR biomarker GlycA
US9928345B2 (en) 2012-06-08 2018-03-27 Liposciences, Inc. Multiple-marker risk parameters predictive of conversion to diabetes
US9361429B2 (en) 2012-06-08 2016-06-07 Liposcience, Inc. Multi-parameter diabetes risk evaluations
RU2533846C1 (ru) * 2013-05-13 2014-11-20 Сергей Леонидович Устьянцев Способ определения энтропии в организме человека или животного
CN104215623B (zh) * 2013-05-31 2018-09-25 欧普图斯(苏州)光学纳米科技有限公司 面向多行业检测的激光拉曼光谱智能化辨识方法及系统
US9953417B2 (en) 2013-10-04 2018-04-24 The University Of Manchester Biomarker method
US9519823B2 (en) * 2013-10-04 2016-12-13 The University Of Manchester Biomarker method
CN107764848A (zh) * 2016-08-18 2018-03-06 中国科学院烟台海岸带研究所 一种基于代谢组学评价石斑鱼饲料利用的方法
CN108766587B (zh) * 2018-05-11 2022-05-03 北京诺道认知医学科技有限公司 一种基于指定药物构建给药数据库的方法及装置
CN108717876B (zh) * 2018-05-11 2022-05-20 大连诺道认知医学技术有限公司 一种基于指定药物构建给药数据库的方法及装置
CN108445112B (zh) * 2018-05-29 2021-03-16 云南中烟工业有限责任公司 一种烟叶烟气中4-(n-甲基-n-亚硝胺)-1-(3-吡啶基)-丁酮的检测方法
WO2020081326A1 (en) * 2018-10-15 2020-04-23 Olaris, Inc. Spectographic metabolite-signature for identifying a subject's susceptibility to drugs
JP2022550916A (ja) 2019-10-10 2022-12-05 ジョージア テック リサーチ コーポレイション 深紫外線顕微鏡を用いた無標識の血液学的および組織病理学的分析
ES2955072T3 (es) * 2019-10-17 2023-11-28 Evonik Operations Gmbh Método de predicción de un valor de propiedad de un material usando análisis de componentes principales
CN120359409A (zh) * 2022-08-31 2025-07-22 美国控股实验室公司 通过nmr波谱法测量柠檬酸根和肌酐水平的方法和系统
WO2025028546A1 (ja) * 2023-08-01 2025-02-06 国立大学法人奈良先端科学技術大学院大学 電磁波散乱スペクトルによる細胞判別方法および装置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6658396B1 (en) * 1999-11-29 2003-12-02 Tang Sharon S Neural network drug dosage estimation
WO2002010746A2 (en) * 2000-07-28 2002-02-07 Lion Bioscience Ag Pharmacokinetic tool and method for predicting metabolism of a compound in a mammal
IN2004DN03762A (cg-RX-API-DMAC7.html) 2002-06-14 2010-01-08 Pfizer

Also Published As

Publication number Publication date
HRP20041174A2 (en) 2005-06-30
DE60336403D1 (de) 2011-04-28
NO20045111L (no) 2005-01-12
US20090192721A1 (en) 2009-07-30
KR20050012281A (ko) 2005-01-31
CA2487836A1 (en) 2003-12-24
CA2487836C (en) 2014-12-02
WO2003107270A3 (en) 2005-04-21
WO2003107270A2 (en) 2003-12-24
EP1540560A2 (en) 2005-06-15
US8577617B2 (en) 2013-11-05
US20050074745A1 (en) 2005-04-07
ATE502343T1 (de) 2011-04-15
RU2004136317A (ru) 2006-01-27
AU2003232406A1 (en) 2003-12-31
IL165329A0 (en) 2006-01-15
IN2004DN03762A (cg-RX-API-DMAC7.html) 2010-01-08
JP2005534899A (ja) 2005-11-17
JP4829496B2 (ja) 2011-12-07
EP1540560B1 (en) 2011-03-16

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