HK1074389A1 - Small organic molecules that increase the activity of gelatinase a in ocular cells - Google Patents

Small organic molecules that increase the activity of gelatinase a in ocular cells

Info

Publication number
HK1074389A1
HK1074389A1 HK05105871.8A HK05105871A HK1074389A1 HK 1074389 A1 HK1074389 A1 HK 1074389A1 HK 05105871 A HK05105871 A HK 05105871A HK 1074389 A1 HK1074389 A1 HK 1074389A1
Authority
HK
Hong Kong
Prior art keywords
organic molecules
small organic
increase
activity
gelatinase
Prior art date
Application number
HK05105871.8A
Other languages
English (en)
Inventor
Bruce Alan Pfeffer
Rosemarie Beth Flick
Naveed Bin Kamal Shams
Stephen Paul Bartels
Original Assignee
Bausch & Lomb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bausch & Lomb filed Critical Bausch & Lomb
Publication of HK1074389A1 publication Critical patent/HK1074389A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/10—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Enzymes And Modification Thereof (AREA)
HK05105871.8A 2002-09-27 2005-07-11 Small organic molecules that increase the activity of gelatinase a in ocular cells HK1074389A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/260,448 US7071211B2 (en) 2002-09-27 2002-09-27 Small organic molecules that increase the activity of gelatinase a in ocular cells
PCT/US2003/029528 WO2004028538A1 (en) 2002-09-27 2003-09-19 Small organic molecules that increase the activity of gelatinase a in ocular cells

Publications (1)

Publication Number Publication Date
HK1074389A1 true HK1074389A1 (en) 2005-11-11

Family

ID=32041805

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05105871.8A HK1074389A1 (en) 2002-09-27 2005-07-11 Small organic molecules that increase the activity of gelatinase a in ocular cells

Country Status (18)

Country Link
US (2) US7071211B2 (ko)
EP (1) EP1542687B1 (ko)
JP (1) JP2006503070A (ko)
KR (1) KR20050057581A (ko)
CN (1) CN1684682A (ko)
AT (1) ATE421879T1 (ko)
AU (1) AU2003278842B2 (ko)
BR (1) BR0314802A (ko)
CA (1) CA2500200A1 (ko)
DE (1) DE60326051D1 (ko)
ES (1) ES2320440T3 (ko)
HK (1) HK1074389A1 (ko)
MX (1) MXPA05003113A (ko)
PL (1) PL375046A1 (ko)
RU (1) RU2005111964A (ko)
TW (1) TW200407158A (ko)
UA (1) UA81922C2 (ko)
WO (1) WO2004028538A1 (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1730476B (zh) * 2004-08-06 2011-04-06 中国医学科学院药物研究所 芳胺酮类化合物、其合成方法、含有其的药物组合物及用途
KR100784337B1 (ko) * 2004-11-12 2007-12-13 한국생명공학연구원 신규한 ｏ-아실옥심 유도체, 그의 제조방법 및 이를유효성분으로 하는 심장순환계 질환의 예방 및 치료용약학 조성물
US20060111388A1 (en) * 2004-11-19 2006-05-25 University Of North Texas Health Science Center At Fort Worth Phenanthroline and derivatives thereof used to lower intraocular pressure in an affected eye
CA2608476A1 (en) * 2005-06-28 2007-01-04 Bausch & Lomb Incorporated Preparations comprising arylazine substituted with a carbonylic moiety to increase the activity of gelatinase a in ocular cells
US20070004672A1 (en) * 2005-07-01 2007-01-04 Dharmendra Jani Long lasting alginate dry eye, related methods of manufacture and methods of use
US8202226B2 (en) * 2007-01-23 2012-06-19 Kci Licensing, Inc. Providing automated or manual guidance on dynamic patient positioning based on measured variables for ventilation control
CN103387960B (zh) * 2013-07-22 2015-08-19 南京医科大学 mTOR信号通路激活剂及其在原始卵泡体外激活中的应用
MX2016016480A (es) * 2014-07-02 2017-08-02 Inflectis Bioscience Nuevos usos terapeuticos de derivados de bencilidenguanidina para el tratamiento de proteopatias.
US10544093B2 (en) * 2014-07-02 2020-01-28 Inflectis Bioscience O-alkyl-benzylideneguanidine derivatives and therapeutic use for the treatment of disorders associated an accumulation of misfolded proteins
US20180230105A1 (en) 2017-01-13 2018-08-16 Regents Of The University Of Minnesota Therapeutic compounds
US20210177814A1 (en) 2018-05-09 2021-06-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of guanabenz or derivates thereof for the treatment of type i ifn-dependent pathologies
CN113072467B (zh) * 2021-03-24 2022-04-12 南方医科大学 含取代胍基衍生物及其在制备破骨细胞分化抑制剂上的应用

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US3290320A (en) * 1963-06-12 1966-12-06 Schering Corp Benzoyl pyridine oximino ethers and methods for their manufacture
GB1019120A (en) 1964-03-18 1966-02-02 Shell Int Research Novel hydrazine compounds and compositions containing them
US3975533A (en) * 1970-04-29 1976-08-17 Shell Oil Company Therapeutic agents
US3686409A (en) * 1971-01-27 1972-08-22 Abbott Lab Combination of l-dopa and 2-imino-5-phenyl-4-oxazolidinone used to treat parkinson{40 s disease
FR2178304A5 (ko) 1972-03-27 1973-11-09 Rhone Poulenc Sa
GB1458355A (en) * 1973-01-31 1976-12-15 Agfa Gevaert Recording processes and materials containing a photo-and or thermo-sensitive amine progenitor
GB1554708A (en) * 1975-09-16 1979-10-24 Agfa Gevaert Stabilization of free-radical photosensitive materials
AT365410B (de) * 1978-08-31 1982-01-11 Ciba Geigy Ag Mittel zum schutz von kulturpflanzen vor aggressi-ven herbiziden
US4347372A (en) * 1978-09-01 1982-08-31 Ciba-Geigy Corporation Benzoxazolyl-glyoxylonitrile-2-oxime ether derivatives
US4453974A (en) * 1980-01-14 1984-06-12 Ciba-Geigy Corporation Phenyl- and naphthyl-glyoxylonitrile oximino carbamates for the protection of crops against injury by herbicides
FR2477537A1 (fr) 1980-03-07 1981-09-11 Francaise Sucrerie Nouvelles guanidines acylees, urees et urees substituees, leur procede de fabrication et leur application en tant que medicaments
JPS59157637A (ja) * 1983-02-25 1984-09-07 Fuji Photo Film Co Ltd 熱現像カラ−感光材料
US5260059A (en) * 1989-04-14 1993-11-09 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University Treatment of open-angle glaucoma by modulation matrix metalloproteinases and their inhibitor
CA2149640A1 (en) * 1992-11-25 1994-06-09 Kevin T. Chapman Carboxy-peptidyl derivatives as antidegenerative active agents
US5668133A (en) * 1992-12-09 1997-09-16 Alcon Laboratories, Inc. Ophthalmic compositions comprising emedastine and methods for their use
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Also Published As

Publication number Publication date
PL375046A1 (en) 2005-11-14
US7071211B2 (en) 2006-07-04
US20040068017A1 (en) 2004-04-08
WO2004028538A1 (en) 2004-04-08
JP2006503070A (ja) 2006-01-26
UA81922C2 (uk) 2008-02-25
DE60326051D1 (de) 2009-03-19
KR20050057581A (ko) 2005-06-16
TW200407158A (en) 2004-05-16
RU2005111964A (ru) 2005-10-10
EP1542687A1 (en) 2005-06-22
US20060121090A1 (en) 2006-06-08
CN1684682A (zh) 2005-10-19
CA2500200A1 (en) 2004-04-08
ES2320440T3 (es) 2009-05-22
ATE421879T1 (de) 2009-02-15
AU2003278842A1 (en) 2004-04-19
EP1542687B1 (en) 2009-01-28
MXPA05003113A (es) 2005-06-22
BR0314802A (pt) 2005-08-09
AU2003278842B2 (en) 2009-05-28

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20120919