HK1069189A1 - A method for determining the activity and/or side-effects of a medicament by detecting the ratio of a mitochondrial nucleic acid in relation to a nuclear nucleic acid - Google Patents

A method for determining the activity and/or side-effects of a medicament by detecting the ratio of a mitochondrial nucleic acid in relation to a nuclear nucleic acid

Info

Publication number
HK1069189A1
HK1069189A1 HK05101744A HK05101744A HK1069189A1 HK 1069189 A1 HK1069189 A1 HK 1069189A1 HK 05101744 A HK05101744 A HK 05101744A HK 05101744 A HK05101744 A HK 05101744A HK 1069189 A1 HK1069189 A1 HK 1069189A1
Authority
HK
Hong Kong
Prior art keywords
nucleic acid
medicament
activity
relation
detecting
Prior art date
Application number
HK05101744A
Other languages
English (en)
Inventor
Bob Van Gemen
Eveline Catherina A Timmermans
Anthonij De Ronde
Irene Johanna Monica Dobbelaer
Original Assignee
Primagen B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP00204322A external-priority patent/EP1211323A1/en
Application filed by Primagen B V filed Critical Primagen B V
Publication of HK1069189A1 publication Critical patent/HK1069189A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
HK05101744A 2000-12-04 2005-03-01 A method for determining the activity and/or side-effects of a medicament by detecting the ratio of a mitochondrial nucleic acid in relation to a nuclear nucleic acid HK1069189A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00204322A EP1211323A1 (en) 2000-12-04 2000-12-04 Tests based on nucleic acids of endosymbiont cellular organelles
EP01202168 2001-06-06
PCT/NL2001/000883 WO2002046470A2 (en) 2000-12-04 2001-12-04 Testing endosymbiont cellular organelles and compounds identifiable therewith

Publications (1)

Publication Number Publication Date
HK1069189A1 true HK1069189A1 (en) 2005-05-13

Family

ID=26072883

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05101744A HK1069189A1 (en) 2000-12-04 2005-03-01 A method for determining the activity and/or side-effects of a medicament by detecting the ratio of a mitochondrial nucleic acid in relation to a nuclear nucleic acid

Country Status (13)

Country Link
US (2) US6967016B2 (zh)
EP (1) EP1229130B1 (zh)
JP (1) JP4472253B2 (zh)
KR (1) KR20040034582A (zh)
CN (1) CN1322143C (zh)
AU (2) AU2002219707A1 (zh)
CA (1) CA2364294C (zh)
DK (1) DK1229130T3 (zh)
ES (1) ES2445748T3 (zh)
HK (1) HK1069189A1 (zh)
IL (1) IL156286A0 (zh)
NZ (2) NZ526519A (zh)
WO (1) WO2002046470A2 (zh)

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US20050153381A1 (en) * 2002-02-14 2005-07-14 Marusich Michael F. Immunocapture of mitochondrial protein complexes
EP1418242A1 (en) * 2002-11-08 2004-05-12 PrimaGen Holding B.V. Method for quantifying a ratio between at least two nucleic acid sequences
AU2003279621A1 (en) * 2002-11-08 2004-06-07 Primagen Holding B.V. Method for quantifying a ratio between at least two nucleic acid sequences
EP1418241A1 (en) * 2002-11-08 2004-05-12 PrimaGen Holding B.V. Method for quantifying a ratio between at least two nucleic acid sequences
US20040110241A1 (en) * 2002-12-06 2004-06-10 Segal Mark S. Materials and methods for monitoring vascular endothelial function
CN104383542B (zh) 2003-04-08 2017-09-26 普罗热尼奇制药公司 包含甲基纳曲酮的药物配方
DK2270159T3 (en) * 2003-05-21 2015-04-20 Andes Biotechnologies S A Markers for pre-cancerous cells and cancer cells and a method for affecting cell proliferation
EP1493823A1 (en) * 2003-07-02 2005-01-05 PrimaGen Holding B.V. HMG coenzyme A reductase inhibitors affect the mitochondrial DNA content of cells
US20070077578A1 (en) * 2004-03-02 2007-04-05 Primagen Holding B.V. Diagnosis of (a risk of ) disease and monitoring of therapy
EP1571225A1 (en) * 2004-03-02 2005-09-07 PrimaGen Holding B.V. Diagnosis of a disease and monitoring of therapy using the AC133 gene
JP5435864B2 (ja) 2004-05-28 2014-03-05 アシュラジェン インコーポレイテッド マイクロｒｎａに関与する方法および組成物
EP1652935A1 (en) * 2004-10-29 2006-05-03 PrimaGen Holding B.V. Methods using mitochondrial nucleic acid for determining a health status of an individual
EP1807532B1 (en) 2004-10-29 2015-03-11 PrimaGen Holding B.V. Methods using mitochondrial nucleic acid for determining a health status of an individual
DK2302055T3 (da) 2004-11-12 2014-10-13 Asuragen Inc Fremgangsmåder og sammensætninger involverende miRNA og miRNA-inhibitormolekyler
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
MX2007010833A (es) 2005-03-07 2009-02-17 Univ Chicago Uso de antagonistas opioides para atenuar proliferacion y migracion de células endoteliales.
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
US20070072211A1 (en) 2005-06-30 2007-03-29 Roche Molecular Systems, Inc. Asymmetric PCR coupled with post-PCR characterization for the identification of nucleic acids
US20070134678A1 (en) * 2005-12-12 2007-06-14 Rees Dianne M Comparative genome hybridization of organelle genomes
EP2115138A2 (en) * 2006-09-19 2009-11-11 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
MX351611B (es) 2007-03-29 2017-10-20 Wyeth Llc Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas.
SI2139890T1 (sl) 2007-03-29 2014-12-31 Wyeth Llc Antagonisti perifernih opioidnih receptorjev in njih uporaba
PA8774201A1 (es) 2007-03-29 2009-06-23 Progenics Pharm Inc Antagonista del receptor
US20090024330A1 (en) * 2007-07-19 2009-01-22 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems relating to epigenetic phenotypes
US20090022666A1 (en) * 2007-07-19 2009-01-22 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems relating to mitochondrial DNA information
US20090024333A1 (en) * 2007-07-19 2009-01-22 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems relating to mitochondrial DNA phenotypes
EP2198050A1 (en) 2007-09-14 2010-06-23 Asuragen, INC. Micrornas differentially expressed in cervical cancer and uses thereof
US8071562B2 (en) 2007-12-01 2011-12-06 Mirna Therapeutics, Inc. MiR-124 regulated genes and pathways as targets for therapeutic intervention
EP2730578A1 (en) 2008-02-06 2014-05-14 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnal trexone
EP2278966B1 (en) 2008-03-21 2019-10-09 The University of Chicago Treatment with opioid antagonists and mtor inhibitors
EP2285960B1 (en) 2008-05-08 2015-07-08 Asuragen, INC. Compositions and methods related to mir-184 modulation of neovascularization or angiogenesis
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
WO2012097849A2 (en) * 2011-01-18 2012-07-26 Merck Patent Gmbh Mitochondrial genome-restricted dna sequences
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease

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US5506101A (en) * 1993-06-30 1996-04-09 Cedars-Sinai Medical Center Method for detection of susceptibility mutations for ototoxic deafness
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Also Published As

Publication number Publication date
JP4472253B2 (ja) 2010-06-02
DK1229130T3 (en) 2014-02-24
CA2364294C (en) 2013-04-02
WO2002046470A3 (en) 2004-01-15
US20050208549A1 (en) 2005-09-22
EP1229130A3 (en) 2003-10-22
CN1526022A (zh) 2004-09-01
IL156286A0 (en) 2004-01-04
ES2445748T3 (es) 2014-03-05
CA2364294A1 (en) 2002-06-04
EP1229130B1 (en) 2013-11-20
AU2008200491B2 (en) 2011-04-28
NZ526519A (en) 2006-08-31
AU2008200491A8 (en) 2011-05-26
JP2004530416A (ja) 2004-10-07
AU2008200491B8 (en) 2011-05-26
US20020164612A1 (en) 2002-11-07
US6967016B2 (en) 2005-11-22
KR20040034582A (ko) 2004-04-28
CN1322143C (zh) 2007-06-20
WO2002046470A2 (en) 2002-06-13
EP1229130A2 (en) 2002-08-07
AU2008200491A1 (en) 2008-02-21
NZ543940A (en) 2008-04-30
AU2002219707A1 (en) 2002-06-18

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PE Patent expired

Effective date: 20211203