HK1047752A1 - 具有核激素受體調節活性的有機硅化合物 - Google Patents
具有核激素受體調節活性的有機硅化合物Info
- Publication number
- HK1047752A1 HK1047752A1 HK02109360.1A HK02109360A HK1047752A1 HK 1047752 A1 HK1047752 A1 HK 1047752A1 HK 02109360 A HK02109360 A HK 02109360A HK 1047752 A1 HK1047752 A1 HK 1047752A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- nuclear hormone
- hormone receptor
- modulating activity
- receptor modulating
- organosilyl compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/0805—Compounds with Si-C or Si-Si linkages comprising only Si, C or H atoms
- C07F7/0807—Compounds with Si-C or Si-Si linkages comprising only Si, C or H atoms comprising Si as a ring atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13873199P | 1999-06-11 | 1999-06-11 | |
| PCT/US2000/015972 WO2000077011A1 (en) | 1999-06-11 | 2000-06-09 | Organosilyl compounds having nuclear hormone receptor modulating activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1047752A1 true HK1047752A1 (zh) | 2003-03-07 |
Family
ID=22483369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK02109360.1A HK1047752A1 (zh) | 1999-06-11 | 2002-12-27 | 具有核激素受體調節活性的有機硅化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6452032B1 (zh) |
| EP (1) | EP1185539B1 (zh) |
| JP (1) | JP2003502337A (zh) |
| CN (1) | CN1368975A (zh) |
| AT (1) | ATE283860T1 (zh) |
| AU (1) | AU774538B2 (zh) |
| BR (1) | BR0011741A (zh) |
| CA (1) | CA2375797A1 (zh) |
| DE (1) | DE60016404T2 (zh) |
| HK (1) | HK1047752A1 (zh) |
| WO (1) | WO2000077011A1 (zh) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030144360A1 (en) * | 2001-11-19 | 2003-07-31 | Allergan Sales, Inc. | Composition and method for modulating BAR/FXR receptor activity |
| JP4434740B2 (ja) * | 2001-12-19 | 2010-03-17 | ブリストル−マイヤーズ スクイブ カンパニー | 核ホルモン受容体機能の調節剤である、縮合ヘテロ環化合物およびその類似体 |
| EP1465882B1 (en) * | 2001-12-21 | 2011-08-24 | X-Ceptor Therapeutics, Inc. | Hetrocyclic modulators of nuclear receptors |
| WO2004048391A1 (en) * | 2002-11-25 | 2004-06-10 | Amedis Pharmaceuticals Ltd. | Silicon compounds to be used as ligands for retinoid receptors |
| US7618956B2 (en) * | 2005-05-31 | 2009-11-17 | The Gillette Company | Reduction of hair growth |
| EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| ES2898676T3 (es) | 2015-11-25 | 2022-03-08 | Io Therapeutics Inc | Agonistas selectivos de rar-alfa resistentes a CYP26 en el tratamiento del cáncer |
| CN115671292A (zh) | 2016-06-10 | 2023-02-03 | Io治疗公司 | 用于癌症免疫疗法的受体选择性类视黄醇和rexinoid化合物和免疫调节剂 |
| MX2018015443A (es) | 2016-06-13 | 2019-04-11 | Gilead Sciences Inc | Compuestos moduladores de fxr (nr1h4). |
| CA2968836A1 (en) | 2016-06-13 | 2017-12-13 | Gilead Sciences, Inc. | Fxr (nr1h4) modulating compounds |
| US20180280394A1 (en) | 2017-03-28 | 2018-10-04 | Gilead Sciences, Inc. | Methods of treating liver disease |
| EP3651764A4 (en) | 2017-07-13 | 2021-09-22 | IO Therapeutics, Inc. | RETINOID AND REXINOID COMPOUNDS IMMUNOMODULATORS IN COMBINATION WITH IMMUNE MODULATORS FOR CANCER IMMUNOTHERAPY |
| EP3675843A4 (en) | 2017-08-31 | 2021-11-03 | IO Therapeutics, Inc. | RAR-SELECTIVE AGONISTS IN COMBINATION WITH IMMUNE MODULATORS FOR CANCER THERAPY |
| CR20210385A (es) | 2019-01-15 | 2021-09-14 | Gilead Sciences Inc | Compuestos moduladores de fxr (nr1h4) |
| KR20210129128A (ko) | 2019-02-19 | 2021-10-27 | 길리애드 사이언시즈, 인코포레이티드 | Fxr 효능제의 고체 형태 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4588715A (en) * | 1984-06-04 | 1986-05-13 | Sandoz, Inc. | Heptenoic acid derivatives |
| US5071773A (en) | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
| US5234926A (en) | 1987-03-20 | 1993-08-10 | Allergan, Inc. | Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity |
| US5162546A (en) | 1989-09-19 | 1992-11-10 | Allergan, Inc. | Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity |
| US5272156A (en) | 1989-09-19 | 1993-12-21 | Allergan, Inc. | Acetylenes disubstituted with a heteroaromatic group and a 2-substituted 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity |
| US5053523A (en) | 1989-09-19 | 1991-10-01 | Allergan, Inc. | Ethynyl-chroman compounds |
| WO1992017471A1 (en) | 1991-03-26 | 1992-10-15 | Allergan, Inc. | Chromans and thiochromans with heteroarylethynyl substituents at the 7-position having retinoid-like biological activity |
| US5134159A (en) | 1991-03-26 | 1992-07-28 | Allergan, Inc. | 7-chromanyl esters of phenols and benzoic acids having retinoid-like activity |
| US5776699A (en) | 1995-09-01 | 1998-07-07 | Allergan, Inc. | Method of identifying negative hormone and/or antagonist activities |
| US5877207A (en) | 1996-03-11 | 1999-03-02 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
| JP2856175B2 (ja) * | 1996-10-25 | 1999-02-10 | 日本電気株式会社 | 液晶添加剤、液晶組成物およびそれを用いた液晶表示素子 |
| AU2409600A (en) | 1999-01-07 | 2000-07-24 | Tularik Inc. | Fxr receptor-mediated modulation of cholesterol metabolism |
-
2000
- 2000-06-09 AU AU56040/00A patent/AU774538B2/en not_active Ceased
- 2000-06-09 WO PCT/US2000/015972 patent/WO2000077011A1/en active IP Right Grant
- 2000-06-09 JP JP2001503868A patent/JP2003502337A/ja active Pending
- 2000-06-09 DE DE60016404T patent/DE60016404T2/de not_active Expired - Fee Related
- 2000-06-09 EP EP00941321A patent/EP1185539B1/en not_active Expired - Lifetime
- 2000-06-09 AT AT00941321T patent/ATE283860T1/de not_active IP Right Cessation
- 2000-06-09 CN CN00811425A patent/CN1368975A/zh active Pending
- 2000-06-09 US US09/591,042 patent/US6452032B1/en not_active Expired - Fee Related
- 2000-06-09 BR BR0011741-2A patent/BR0011741A/pt not_active IP Right Cessation
- 2000-06-09 CA CA002375797A patent/CA2375797A1/en not_active Abandoned
-
2002
- 2002-12-27 HK HK02109360.1A patent/HK1047752A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60016404D1 (de) | 2005-01-05 |
| US6452032B1 (en) | 2002-09-17 |
| CN1368975A (zh) | 2002-09-11 |
| WO2000077011A1 (en) | 2000-12-21 |
| AU5604000A (en) | 2001-01-02 |
| AU774538B2 (en) | 2004-07-01 |
| EP1185539B1 (en) | 2004-12-01 |
| ATE283860T1 (de) | 2004-12-15 |
| CA2375797A1 (en) | 2000-12-21 |
| JP2003502337A (ja) | 2003-01-21 |
| BR0011741A (pt) | 2002-03-19 |
| EP1185539A1 (en) | 2002-03-13 |
| DE60016404T2 (de) | 2005-10-27 |
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