ATE283860T1 - Organosiliciumvebindungen mit der fähigkeit zur modulation von im zellkern lokalisierten hormonrezeptoren - Google Patents
Organosiliciumvebindungen mit der fähigkeit zur modulation von im zellkern lokalisierten hormonrezeptorenInfo
- Publication number
- ATE283860T1 ATE283860T1 AT00941321T AT00941321T ATE283860T1 AT E283860 T1 ATE283860 T1 AT E283860T1 AT 00941321 T AT00941321 T AT 00941321T AT 00941321 T AT00941321 T AT 00941321T AT E283860 T1 ATE283860 T1 AT E283860T1
- Authority
- AT
- Austria
- Prior art keywords
- ability
- hormone receptors
- organosilicon compounds
- cell nuclear
- receptors localized
- Prior art date
Links
- 108091008039 hormone receptors Proteins 0.000 title 1
- 150000003961 organosilicon compounds Chemical class 0.000 title 1
- 102000007399 Nuclear hormone receptor Human genes 0.000 abstract 1
- 108020005497 Nuclear hormone receptor Proteins 0.000 abstract 1
- 150000002894 organic compounds Chemical class 0.000 abstract 1
- 229920001296 polysiloxane Polymers 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 102000027483 retinoid hormone receptors Human genes 0.000 abstract 1
- 108091008679 retinoid hormone receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/0805—Compounds with Si-C or Si-Si linkages comprising only Si, C or H atoms
- C07F7/0807—Compounds with Si-C or Si-Si linkages comprising only Si, C or H atoms comprising Si as a ring atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13873199P | 1999-06-11 | 1999-06-11 | |
| PCT/US2000/015972 WO2000077011A1 (en) | 1999-06-11 | 2000-06-09 | Organosilyl compounds having nuclear hormone receptor modulating activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE283860T1 true ATE283860T1 (de) | 2004-12-15 |
Family
ID=22483369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00941321T ATE283860T1 (de) | 1999-06-11 | 2000-06-09 | Organosiliciumvebindungen mit der fähigkeit zur modulation von im zellkern lokalisierten hormonrezeptoren |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6452032B1 (de) |
| EP (1) | EP1185539B1 (de) |
| JP (1) | JP2003502337A (de) |
| CN (1) | CN1368975A (de) |
| AT (1) | ATE283860T1 (de) |
| AU (1) | AU774538B2 (de) |
| BR (1) | BR0011741A (de) |
| CA (1) | CA2375797A1 (de) |
| DE (1) | DE60016404T2 (de) |
| HK (1) | HK1047752A1 (de) |
| WO (1) | WO2000077011A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030144360A1 (en) * | 2001-11-19 | 2003-07-31 | Allergan Sales, Inc. | Composition and method for modulating BAR/FXR receptor activity |
| HUP0500096A3 (en) * | 2001-12-19 | 2012-08-28 | Bristol Myers Squibb Co | Fused heterocyclic compounds and analogs thereof: modulators of nuclear hormone receptor function, process for producing them and pharmaceutical compositions containing them |
| EP1465882B1 (de) * | 2001-12-21 | 2011-08-24 | X-Ceptor Therapeutics, Inc. | Heterocyclische modulatoren von nukleären rezeptoren |
| AU2003286245A1 (en) * | 2002-11-25 | 2004-06-18 | Amedis Pharmaceuticals Ltd. | Silicon compounds to be used as ligands for retinoid receptors |
| US7618956B2 (en) * | 2005-05-31 | 2009-11-17 | The Gillette Company | Reduction of hair growth |
| EP2545964A1 (de) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Neuartige FXR- (NR1H4)-Binde- und -Aktivitätsmodulationsverbindungen |
| US10940127B2 (en) | 2015-11-25 | 2021-03-09 | Io Therapeutics, Inc. | Use of CYP26-resistant RAR alpha selective agonists in the treatment of cancer |
| JP2019517557A (ja) | 2016-06-10 | 2019-06-24 | アイオー セラピューティクス インコーポレイテッド | 癌免疫療法のための受容体選択的レチノイドおよびレキシノイド化合物および免疫調節因子 |
| CA2968836C (en) | 2016-06-13 | 2025-09-02 | Gilead Sciences, Inc. | FXR MODULATING COMPOUNDS (NR1H4) |
| ES2921432T3 (es) | 2016-06-13 | 2022-08-25 | Gilead Sciences Inc | Derivados de azetidina como moduladores de FXR (NR1H4) |
| EP4424364B1 (de) | 2017-03-28 | 2026-01-21 | Gilead Sciences, Inc. | Kombinationen zur verwendung bei der behandlung von zirrhose und leberfibrose |
| AU2018301810A1 (en) | 2017-07-13 | 2020-01-23 | Io Therapeutics, Inc. | Receptor subtype and function selective retinoid and rexinoid compounds in combination with immune modulators for cancer immunotherapy |
| US10363272B2 (en) | 2017-08-31 | 2019-07-30 | Io Therapeutics, Inc. | RAR selective agonists in combination with immune modulators for cancer immunotherapy |
| PE20211907A1 (es) | 2019-01-15 | 2021-09-28 | Gilead Sciences Inc | Compuestos moduladores de fxr (nr1h4) |
| KR102725082B1 (ko) | 2019-02-19 | 2024-11-04 | 길리애드 사이언시즈, 인코포레이티드 | Fxr 효능제의 고체 형태 |
| CN115246856A (zh) * | 2021-04-27 | 2022-10-28 | 上海旭成医药科技有限公司 | 视黄酸受体激动剂、其制备方法、中间体、药物组合物和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4588715A (en) * | 1984-06-04 | 1986-05-13 | Sandoz, Inc. | Heptenoic acid derivatives |
| US5071773A (en) | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
| US5234926A (en) | 1987-03-20 | 1993-08-10 | Allergan, Inc. | Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity |
| US5272156A (en) | 1989-09-19 | 1993-12-21 | Allergan, Inc. | Acetylenes disubstituted with a heteroaromatic group and a 2-substituted 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity |
| US5162546A (en) | 1989-09-19 | 1992-11-10 | Allergan, Inc. | Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity |
| US5053523A (en) | 1989-09-19 | 1991-10-01 | Allergan, Inc. | Ethynyl-chroman compounds |
| US5134159A (en) | 1991-03-26 | 1992-07-28 | Allergan, Inc. | 7-chromanyl esters of phenols and benzoic acids having retinoid-like activity |
| IE920949A1 (en) | 1991-03-26 | 1992-10-07 | Allergan Inc | Chromans and thiochromans with heteroarylethynyl¹substituents at the 7-position having retinoid-like¹biological activity |
| US5776699A (en) | 1995-09-01 | 1998-07-07 | Allergan, Inc. | Method of identifying negative hormone and/or antagonist activities |
| US5877207A (en) | 1996-03-11 | 1999-03-02 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
| JP2856175B2 (ja) * | 1996-10-25 | 1999-02-10 | 日本電気株式会社 | 液晶添加剤、液晶組成物およびそれを用いた液晶表示素子 |
| US6465258B1 (en) | 1999-01-07 | 2002-10-15 | Tularik, Inc. | FXR receptor-mediated modulation cholesterol metabolism |
-
2000
- 2000-06-09 AT AT00941321T patent/ATE283860T1/de not_active IP Right Cessation
- 2000-06-09 US US09/591,042 patent/US6452032B1/en not_active Expired - Fee Related
- 2000-06-09 CN CN00811425A patent/CN1368975A/zh active Pending
- 2000-06-09 WO PCT/US2000/015972 patent/WO2000077011A1/en not_active Ceased
- 2000-06-09 JP JP2001503868A patent/JP2003502337A/ja active Pending
- 2000-06-09 EP EP00941321A patent/EP1185539B1/de not_active Expired - Lifetime
- 2000-06-09 DE DE60016404T patent/DE60016404T2/de not_active Expired - Fee Related
- 2000-06-09 BR BR0011741-2A patent/BR0011741A/pt not_active IP Right Cessation
- 2000-06-09 HK HK02109360.1A patent/HK1047752A1/zh unknown
- 2000-06-09 CA CA002375797A patent/CA2375797A1/en not_active Abandoned
- 2000-06-09 AU AU56040/00A patent/AU774538B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN1368975A (zh) | 2002-09-11 |
| CA2375797A1 (en) | 2000-12-21 |
| HK1047752A1 (zh) | 2003-03-07 |
| DE60016404D1 (de) | 2005-01-05 |
| AU774538B2 (en) | 2004-07-01 |
| US6452032B1 (en) | 2002-09-17 |
| BR0011741A (pt) | 2002-03-19 |
| WO2000077011A1 (en) | 2000-12-21 |
| EP1185539B1 (de) | 2004-12-01 |
| AU5604000A (en) | 2001-01-02 |
| JP2003502337A (ja) | 2003-01-21 |
| DE60016404T2 (de) | 2005-10-27 |
| EP1185539A1 (de) | 2002-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |