HK1044542B - 由11β-芳基-17，17-螺硫羥烷取代的類固醇 - Google Patents

由11β-芳基-17，17-螺硫羥烷取代的類固醇

Info

Publication number
HK1044542B
HK1044542B HK02106120.8A HK02106120A HK1044542B HK 1044542 B HK1044542 B HK 1044542B HK 02106120 A HK02106120 A HK 02106120A HK 1044542 B HK1044542 B HK 1044542B
Authority
HK
Hong Kong
Prior art keywords
spirothiolane
beta
aryl
substituted steroids
compounds
Prior art date
Application number
HK02106120.8A
Other languages
English (en)
Other versions
HK1044542A1 (en
Inventor
Edgar Cook C
S Shetty Rupa
A Kepler John
Y -W Lee David
Original Assignee
Res Triangle Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Triangle Inst filed Critical Res Triangle Inst
Publication of HK1044542A1 publication Critical patent/HK1044542A1/xx
Publication of HK1044542B publication Critical patent/HK1044542B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK02106120.8A 1999-07-21 2002-08-21 由11β-芳基-17，17-螺硫羥烷取代的類固醇 HK1044542B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/357,923 US6043235A (en) 1999-07-21 1999-07-21 11β-aryl-17, 17-spirothiolane-substituted steroids
PCT/US2000/019537 WO2001007462A1 (en) 1999-07-21 2000-07-20 11β-ARYL-17,17-SPIROTHIOLANE-SUBSTITUTED STEROIDS

Publications (2)

Publication Number Publication Date
HK1044542A1 HK1044542A1 (en) 2002-10-25
HK1044542B true HK1044542B (zh) 2005-02-25

Family

ID=23407590

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02106120.8A HK1044542B (zh) 1999-07-21 2002-08-21 由11β-芳基-17，17-螺硫羥烷取代的類固醇

Country Status (14)

Country Link
US (1) US6043235A (zh)
EP (1) EP1196428B1 (zh)
JP (1) JP4768181B2 (zh)
KR (1) KR100616025B1 (zh)
AT (1) ATE277071T1 (zh)
AU (1) AU774472B2 (zh)
CA (1) CA2379995C (zh)
DE (1) DE60014096T2 (zh)
DK (1) DK1196428T3 (zh)
ES (1) ES2228584T3 (zh)
HK (1) HK1044542B (zh)
NO (1) NO321524B1 (zh)
PT (1) PT1196428E (zh)
WO (1) WO2001007462A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262042B1 (en) * 1998-05-29 2001-07-17 Research Triangle Institute 17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
EP2422796A3 (en) 2006-03-07 2013-03-13 Geeta Shroff Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
KR200451979Y1 (ko) * 2008-04-11 2011-01-24 정종오 회전형 광고장치
DE102009034367A1 (de) * 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de) * 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2344286A1 (fr) * 1976-03-16 1977-10-14 Roussel Uclaf Nouveaux derives 17-spirosultines, les g-hydroxy acides correspondants, leur procede de preparation et leur application comme medicament
FR2374037A1 (fr) * 1976-10-27 1978-07-13 Roussel Uclaf Nouveaux derives steroides 17-spirosultines les g-hydroxy acides correspondants, leur procede de preparation et leur application comme medicament
ZA929315B (en) * 1991-12-20 1993-05-24 Akzo Nv 17-spirofuran-3'-ylidene steroids.
IL115659A (en) * 1994-10-27 2000-06-01 Akzo Nobel Nv Steroids with a 17-spiromethylene lactone or lactol group process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
US6043235A (en) 2000-03-28
PT1196428E (pt) 2005-02-28
CA2379995A1 (en) 2001-02-01
CA2379995C (en) 2008-10-14
JP4768181B2 (ja) 2011-09-07
NO321524B1 (no) 2006-05-15
EP1196428B1 (en) 2004-09-22
AU774472B2 (en) 2004-07-01
NO20020260L (no) 2002-03-14
DE60014096D1 (de) 2004-10-28
ES2228584T3 (es) 2005-04-16
NO20020260D0 (no) 2002-01-17
DK1196428T3 (da) 2005-01-24
KR100616025B1 (ko) 2006-08-30
KR20020092893A (ko) 2002-12-12
EP1196428A1 (en) 2002-04-17
JP2003531815A (ja) 2003-10-28
DE60014096T2 (de) 2005-10-06
HK1044542A1 (en) 2002-10-25
WO2001007462A1 (en) 2001-02-01
ATE277071T1 (de) 2004-10-15
EP1196428A4 (en) 2002-10-16
AU6220000A (en) 2001-02-13

Similar Documents

Publication Publication Date Title
CA2304770A1 (en) A use of steroidal saponins for the prophylaxis or treatment of dementia, and novel steroidal saponin compounds
EP1310509A3 (en) Novel anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
AU1266900A (en) Betulinic acid and derivatives thereof useful for the treatment of neuroectodermal tumors
PL343018A1 (en) Glucocorticoid-selective anti-inflammatory agents
NO20002676L (no) Androgene steroidforbindelser og en fremgangsmÕte for fremstilling og anvendelse av samme
EP1009755A4 (en) STEROID SULFATASE INHIBITORS AND METHODS OF PRODUCING AND USING THE SAME
UA6044A1 (uk) Спосіб одержання метіленових похідних андроста-1,4 -діен-3,17-діона
YU57201A (sh) 16-hidroksiestratrieni kao selektivno aktivni estrogeni
HK1044542A1 (en) 11-Beta-aryl-17, 17-spirothiolane-substituted steroids.
BG103060A (en) 19-nor-holan steroids as neurochemical initiators of the change of the operation of the hypothalamus in human organism
IL139861A0 (en) 17β-AMINO-AND HYDROXYLAMINO -11 β-ARYLSTEROID DERIVATIVES, METHODS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
BR9713176A (pt) Benzotiofenos amorfos,métodos de preparação e métodos de uso
WO2001062765A3 (en) Small molecule modulators of g protein-coupled receptor six
AP2000001793A0 (en) Novel polymorph forms.
IL154828A0 (en) 17alpha FLUOROALKYL STEROIDS, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS
EP0559706A4 (zh)
BG106078A (en) Thio-oxindole derivatives
EP1148061A3 (en) Process for preparation of 9, 11- epoxy steroids and intermediates useful therein
DE50006244D1 (en) Neue substituierte 3-phenoxy- und 3-phenylalkyloxy-2-phenyl-propylamine
AU3894399A (en) Benzocarbazole and indenoindole derived estrogenic agents
YU71400A (sh) Poboljšani postupak za pripremanje farmaceutski dragocenih derivata norbenzomorfana
MX9300677A (es) Procedimiento mejorado para la preparacion de dienos esteroidales substituidos.
WO1990015067A3 (fr) NOUVEAUX PROCEDES D'OBTENTION DE 6-METHYL 19-NOR STEROIDES ET LEUR CONVERSION EN 19-NOR PREGNADIENES 17α-SUBSTITUES
AU6524800A (en) Processes for the preparation of 2-arylvinyl alkyl ether and 1,4-diaryl-2-fluoro-2-butene compounds
IL150082A (en) Unsaturated 14,15 - cyclopropane

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20180720