HK1012638A1 - Angiostatic steroids - Google Patents

Angiostatic steroids

Info

Publication number
HK1012638A1
HK1012638A1 HK98113831A HK98113831A HK1012638A1 HK 1012638 A1 HK1012638 A1 HK 1012638A1 HK 98113831 A HK98113831 A HK 98113831A HK 98113831 A HK98113831 A HK 98113831A HK 1012638 A1 HK1012638 A1 HK 1012638A1
Authority
HK
Hong Kong
Prior art keywords
disclosed
angiostatic steroids
ocular hypertension
neovascularization
controlling
Prior art date
Application number
HK98113831A
Other languages
English (en)
Inventor
Abbot F Clark
Raymond E Conrow
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/941,485 external-priority patent/US5371078A/en
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Publication of HK1012638A1 publication Critical patent/HK1012638A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0027—Azides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
HK98113831A 1991-11-22 1998-12-17 Angiostatic steroids HK1012638A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US79616991A 1991-11-22 1991-11-22
US89244892A 1992-06-02 1992-06-02
US07/941,485 US5371078A (en) 1988-10-31 1992-09-08 Angiostatic steroids and methods and compositions for controlling ocular hypertension
PCT/US1992/010133 WO1993010141A2 (fr) 1991-11-22 1992-11-23 Steroïdes angiostatiques

Publications (1)

Publication Number Publication Date
HK1012638A1 true HK1012638A1 (en) 1999-08-06

Family

ID=27419924

Family Applications (4)

Application Number Title Priority Date Filing Date
HK02107972.5A HK1046370A1 (zh) 1991-11-22 1998-12-17 抑制血管的類固醇
HK02107973.4A HK1046371A1 (zh) 1991-11-22 1998-12-17 抑制血管的類固醇
HK98113831A HK1012638A1 (en) 1991-11-22 1998-12-17 Angiostatic steroids
HK02107971.6A HK1046369A1 (zh) 1991-11-22 1998-12-17 抑制血管的類固醇

Family Applications Before (2)

Application Number Title Priority Date Filing Date
HK02107972.5A HK1046370A1 (zh) 1991-11-22 1998-12-17 抑制血管的類固醇
HK02107973.4A HK1046371A1 (zh) 1991-11-22 1998-12-17 抑制血管的類固醇

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK02107971.6A HK1046369A1 (zh) 1991-11-22 1998-12-17 抑制血管的類固醇

Country Status (10)

Country Link
EP (4) EP1236469A3 (fr)
JP (1) JP3378245B2 (fr)
AT (1) ATE232540T1 (fr)
AU (1) AU678961B2 (fr)
CA (4) CA2425849C (fr)
DE (1) DE69232925T2 (fr)
DK (1) DK0614463T3 (fr)
ES (1) ES2187503T3 (fr)
HK (4) HK1046370A1 (fr)
WO (1) WO1993010141A2 (fr)

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US5504074A (en) * 1993-08-06 1996-04-02 Children's Medical Center Corporation Estrogenic compounds as anti-angiogenic agents
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WO2004091630A1 (fr) * 2003-04-18 2004-10-28 Advanced Medicine Research Institute Remedes a des affections, a usage ophtalmique
US8477592B2 (en) 2003-05-14 2013-07-02 Qualcomm Incorporated Interference and noise estimation in an OFDM system
US8489949B2 (en) 2003-08-05 2013-07-16 Qualcomm Incorporated Combining grant, acknowledgement, and rate control commands
US7315527B2 (en) 2003-08-05 2008-01-01 Qualcomm Incorporated Extended acknowledgement and rate control channel
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Also Published As

Publication number Publication date
WO1993010141A2 (fr) 1993-05-27
ATE232540T1 (de) 2003-02-15
EP1236469A2 (fr) 2002-09-04
CA2425849A1 (fr) 1993-05-27
HK1046370A1 (zh) 2003-01-10
EP1236471A2 (fr) 2002-09-04
EP1236470A2 (fr) 2002-09-04
EP1236469A3 (fr) 2004-09-01
HK1046371A1 (zh) 2003-01-10
DE69232925D1 (de) 2003-03-20
AU678961B2 (en) 1997-06-19
CA2425841A1 (fr) 1993-05-27
EP1236470A3 (fr) 2004-09-01
EP0614463B1 (fr) 2003-02-12
EP1236471A3 (fr) 2004-12-15
CA2123405C (fr) 2008-01-15
CA2123405A1 (fr) 1993-05-27
ES2187503T3 (es) 2003-06-16
CA2425849C (fr) 2007-02-27
JP3378245B2 (ja) 2003-02-17
AU3223593A (en) 1993-06-15
DE69232925T2 (de) 2003-06-18
DK0614463T3 (da) 2003-03-31
EP0614463A1 (fr) 1994-09-14
CA2425846A1 (fr) 1993-05-27
HK1046369A1 (zh) 2003-01-10
JPH07501081A (ja) 1995-02-02
CA2425841C (fr) 2006-01-10
WO1993010141A3 (fr) 1993-09-02

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20111123