HK1008215A1 - Mercaptoketones and mercaptoalcohols, a process for their preparation and their use as inhibitors of matrix metalloproteinases - Google Patents
Mercaptoketones and mercaptoalcohols, a process for their preparation and their use as inhibitors of matrix metalloproteinasesInfo
- Publication number
- HK1008215A1 HK1008215A1 HK98109083A HK98109083A HK1008215A1 HK 1008215 A1 HK1008215 A1 HK 1008215A1 HK 98109083 A HK98109083 A HK 98109083A HK 98109083 A HK98109083 A HK 98109083A HK 1008215 A1 HK1008215 A1 HK 1008215A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- mmp
- mercaptoalcohols
- preparation
- carboxamido
- alkoxy
- Prior art date
Links
- 108010000684 Matrix Metalloproteinases Proteins 0.000 title abstract 7
- 102000002274 Matrix Metalloproteinases Human genes 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 2
- RVEZZJVBDQCTEF-UHFFFAOYSA-N sulfenic acid Chemical class SO RVEZZJVBDQCTEF-UHFFFAOYSA-N 0.000 title abstract 2
- SKOLWUPSYHWYAM-UHFFFAOYSA-N carbonodithioic O,S-acid Chemical class SC(S)=O SKOLWUPSYHWYAM-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000005518 carboxamido group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 210000002808 connective tissue Anatomy 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 108060005980 Collagenase Proteins 0.000 abstract 1
- 102000029816 Collagenase Human genes 0.000 abstract 1
- 108010026132 Gelatinases Proteins 0.000 abstract 1
- 102000013382 Gelatinases Human genes 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- -1 amino, carboxyl Chemical group 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000000593 degrading effect Effects 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 150000002825 nitriles Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 235000019833 protease Nutrition 0.000 abstract 1
- 108091007196 stromelysin Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
- 230000007838 tissue remodeling Effects 0.000 abstract 1
- 230000008427 tissue turnover Effects 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Catalysts (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pyridine Compounds (AREA)
- Fats And Perfumes (AREA)
- Steroid Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67799496A | 1996-07-10 | 1996-07-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1008215A1 true HK1008215A1 (en) | 1999-05-07 |
Family
ID=24720941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK98109083A HK1008215A1 (en) | 1996-07-10 | 1998-07-11 | Mercaptoketones and mercaptoalcohols, a process for their preparation and their use as inhibitors of matrix metalloproteinases |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0818443B1 (sk) |
| JP (1) | JPH1067737A (sk) |
| KR (1) | KR980009233A (sk) |
| CN (1) | CN1336367A (sk) |
| AT (1) | ATE210113T1 (sk) |
| AU (1) | AU731155B2 (sk) |
| BR (1) | BR9703800A (sk) |
| CA (1) | CA2208676A1 (sk) |
| CZ (1) | CZ202597A3 (sk) |
| DE (1) | DE69708770T2 (sk) |
| DK (1) | DK0818443T3 (sk) |
| ES (1) | ES2166048T3 (sk) |
| HK (1) | HK1008215A1 (sk) |
| HU (1) | HUP9701127A3 (sk) |
| IL (1) | IL121125A0 (sk) |
| NO (1) | NO308597B1 (sk) |
| NZ (1) | NZ328288A (sk) |
| PT (1) | PT818443E (sk) |
| SK (1) | SK88597A3 (sk) |
| TW (1) | TW424083B (sk) |
| ZA (1) | ZA976121B (sk) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994007481A1 (en) * | 1992-10-02 | 1994-04-14 | Merck & Co., Inc. | N-(mercaptoacyl)peptidyl derivatives as antidegenerative agents |
| GB9308695D0 (en) * | 1993-04-27 | 1993-06-09 | Celltech Ltd | Peptidyl derivatives |
| US5831004A (en) * | 1994-10-27 | 1998-11-03 | Affymax Technologies N.V. | Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use |
-
1997
- 1997-06-20 TW TW086108628A patent/TW424083B/zh not_active IP Right Cessation
- 1997-06-20 IL IL12112597A patent/IL121125A0/xx unknown
- 1997-06-23 CA CA002208676A patent/CA2208676A1/en not_active Abandoned
- 1997-06-26 CZ CZ972025A patent/CZ202597A3/cs unknown
- 1997-06-27 NO NO973004A patent/NO308597B1/no unknown
- 1997-06-30 KR KR1019970031756A patent/KR980009233A/ko not_active Application Discontinuation
- 1997-06-30 SK SK885-97A patent/SK88597A3/sk unknown
- 1997-06-30 BR BR9703800A patent/BR9703800A/pt active Search and Examination
- 1997-06-30 HU HU9701127A patent/HUP9701127A3/hu unknown
- 1997-07-08 JP JP9182181A patent/JPH1067737A/ja active Pending
- 1997-07-09 PT PT97305020T patent/PT818443E/pt unknown
- 1997-07-09 DE DE69708770T patent/DE69708770T2/de not_active Expired - Fee Related
- 1997-07-09 EP EP97305020A patent/EP0818443B1/en not_active Expired - Lifetime
- 1997-07-09 NZ NZ328288A patent/NZ328288A/xx unknown
- 1997-07-09 ZA ZA976121A patent/ZA976121B/xx unknown
- 1997-07-09 AT AT97305020T patent/ATE210113T1/de not_active IP Right Cessation
- 1997-07-09 ES ES97305020T patent/ES2166048T3/es not_active Expired - Lifetime
- 1997-07-09 DK DK97305020T patent/DK0818443T3/da active
- 1997-07-10 AU AU28571/97A patent/AU731155B2/en not_active Ceased
-
1998
- 1998-07-11 HK HK98109083A patent/HK1008215A1/xx not_active IP Right Cessation
-
2001
- 2001-04-17 CN CN01117103A patent/CN1336367A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPH1067737A (ja) | 1998-03-10 |
| KR980009233A (ko) | 1998-04-30 |
| NZ328288A (en) | 1999-01-28 |
| DE69708770T2 (de) | 2002-08-08 |
| TW424083B (en) | 2001-03-01 |
| DE69708770D1 (de) | 2002-01-17 |
| IL121125A0 (en) | 1997-11-20 |
| NO973004D0 (no) | 1997-06-27 |
| NO308597B1 (no) | 2000-10-02 |
| EP0818443A2 (en) | 1998-01-14 |
| CN1336367A (zh) | 2002-02-20 |
| CA2208676A1 (en) | 1998-01-10 |
| AU2857197A (en) | 1998-01-22 |
| ATE210113T1 (de) | 2001-12-15 |
| NO973004L (no) | 1998-01-12 |
| HUP9701127A2 (hu) | 1999-02-01 |
| HUP9701127A3 (en) | 2000-08-28 |
| CZ202597A3 (cs) | 1998-09-16 |
| SK88597A3 (en) | 1998-01-14 |
| ES2166048T3 (es) | 2002-04-01 |
| AU731155B2 (en) | 2001-03-22 |
| DK0818443T3 (da) | 2002-04-02 |
| ZA976121B (en) | 1999-01-11 |
| HU9701127D0 (en) | 1997-08-28 |
| BR9703800A (pt) | 1998-08-18 |
| EP0818443B1 (en) | 2001-12-05 |
| PT818443E (pt) | 2002-05-31 |
| EP0818443A3 (en) | 1998-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PF | Patent in force | ||
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20050709 |