GT199800200AA - AZAPOLYCLIC COMPOUNDS CONDENSED WITH ARYL (FRACTIONAL APPLICATION NO. 1, DERIVED FROM PATENT PI-1998-0200). - Google Patents

AZAPOLYCLIC COMPOUNDS CONDENSED WITH ARYL (FRACTIONAL APPLICATION NO. 1, DERIVED FROM PATENT PI-1998-0200).

Info

Publication number
GT199800200AA
GT199800200AA GT199800200AK GT199800200K GT199800200AA GT 199800200A A GT199800200A A GT 199800200AA GT 199800200A K GT199800200A K GT 199800200AK GT 199800200 K GT199800200 K GT 199800200K GT 199800200A A GT199800200A A GT 199800200AA
Authority
GT
Guatemala
Prior art keywords
azapolyclic
aryl
compounds
derived
compounds condensed
Prior art date
Application number
GT199800200AK
Other languages
Spanish (es)
Inventor
Jothan Wadsworth Coe
Paige Roanne Palmer Brooks
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22094096&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT199800200A(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of GT199800200AA publication Critical patent/GT199800200AA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/24—Camphidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

ESTA INVENCION SE REFIERE A COMPUESTOS AZAPOLICICLICOS CONDENSADOS CON ARILO, TALES COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS NEUROLOGICOS Y PSICOLOGICOS; TALES COMO ANSIEDAD, TRASTORNOS DE PANICO, DEPRESION, TRASTORNO BIPOLAR, AUTISMO, TRASTORNOS DEL SUEÑO, ETC. ESTOS COMPUESTOS TIENEN LA ESTRUCTURA QUIMICA (I), EN LA QUE R1, R2, & R3, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE.THIS INVENTION REFERS TO ARYL-CONDENSED AZAPOLYCLIC COMPOUNDS, SUCH COMPOUNDS ARE USEFUL FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS; SUCH AS ANXIETY, PANIC DISORDERS, DEPRESSION, BIPOLAR DISORDER, AUTISM, SLEEP DISORDERS, ETC. THESE COMPOUNDS HAVE THE CHEMICAL STRUCTURE (I), IN WHICH R1, R2, & R3 ARE FUNCTIONAL GROUPS DESCRIBED IN THE FILE.

GT199800200AK 1997-12-31 1998-12-15 AZAPOLYCLIC COMPOUNDS CONDENSED WITH ARYL (FRACTIONAL APPLICATION NO. 1, DERIVED FROM PATENT PI-1998-0200). GT199800200AA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7024597P 1997-12-31 1997-12-31

Publications (1)

Publication Number Publication Date
GT199800200AA true GT199800200AA (en) 2000-06-07

Family

ID=22094096

Family Applications (2)

Application Number Title Priority Date Filing Date
GT199800200A GT199800200A (en) 1997-12-31 1998-12-15 AZAPOLYCLIC COMPOUNDS CONDENSED WITH ARYL.
GT199800200AK GT199800200AA (en) 1997-12-31 1998-12-15 AZAPOLYCLIC COMPOUNDS CONDENSED WITH ARYL (FRACTIONAL APPLICATION NO. 1, DERIVED FROM PATENT PI-1998-0200).

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GT199800200A GT199800200A (en) 1997-12-31 1998-12-15 AZAPOLYCLIC COMPOUNDS CONDENSED WITH ARYL.

Country Status (52)

Country Link
US (6) US6410550B1 (en)
EP (2) EP1044189B2 (en)
JP (1) JP3550359B2 (en)
KR (1) KR100408138B1 (en)
CN (2) CN1324013C (en)
AP (1) AP1170A (en)
AR (1) AR017967A1 (en)
AT (1) ATE386024T1 (en)
AU (1) AU753389C (en)
BG (1) BG65058B1 (en)
BR (2) BR9816186B1 (en)
CA (1) CA2316921C (en)
CO (1) CO4810373A1 (en)
CY (2) CY1107391T1 (en)
CZ (1) CZ301925B6 (en)
DE (2) DE122008000038I1 (en)
DK (1) DK1044189T4 (en)
DZ (1) DZ2697A1 (en)
EA (1) EA003190B1 (en)
EG (1) EG23816A (en)
ES (1) ES2301210T5 (en)
FR (1) FR08C0039I2 (en)
GT (2) GT199800200A (en)
HK (1) HK1031878A1 (en)
HN (1) HN1998000177A (en)
HR (2) HRP20000445B1 (en)
HU (2) HU230297B1 (en)
IL (2) IL136727A0 (en)
IS (1) IS5514A (en)
LU (1) LU91442I2 (en)
MA (1) MA26589A1 (en)
ME (1) ME00459B (en)
MY (1) MY118163A (en)
NL (1) NL300355I2 (en)
NO (2) NO319115B1 (en)
NZ (1) NZ504482A (en)
OA (1) OA11428A (en)
PA (1) PA8463901A1 (en)
PE (1) PE20000053A1 (en)
PL (1) PL209404B1 (en)
PT (1) PT1044189E (en)
RS (1) RS50069B (en)
SA (1) SA99191123B1 (en)
SG (1) SG102686A1 (en)
SI (1) SI1044189T2 (en)
SK (1) SK286886B6 (en)
TN (1) TNSN98237A1 (en)
TR (1) TR200001840T2 (en)
TW (1) TW513412B (en)
UA (1) UA66825C2 (en)
WO (1) WO1999035131A1 (en)
ZA (1) ZA9811911B (en)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1044189T4 (en) * 1997-12-31 2015-03-30 Pfizer Prod Inc Aryl-fused fused azapolycyclic connections
US6605610B1 (en) * 1997-12-31 2003-08-12 Pfizer Inc Aryl fused azapolycyclic compounds
US8188043B2 (en) 1999-07-28 2012-05-29 The Board Of Trustees Of The Leland Stanford Jr. University Nicotine in therapeutic angiogenesis and vasculogenesis
ES2313900T3 (en) 1999-07-28 2009-03-16 The Board Of Trustees Of The Leland Stanford Junior University NICOTINE IN ANGIOGENESIS AND THERAPEUTIC VASCULOGENESIS.
IL137937A0 (en) * 1999-08-27 2001-10-31 Pfizer Prod Inc A pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal
US20020010192A1 (en) * 2000-06-02 2002-01-24 Coe Jotham Wadsworth Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss
US20020016334A1 (en) * 2000-07-31 2002-02-07 Coe Jotham Wadsworth Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD)
DE60225433T2 (en) * 2001-04-20 2008-06-12 Pfizer Products Inc., Groton PROCESS FOR THE PREPARATION OF 1,3-SUBSTITUTED INDENES AND ARYL-ANNULATED AZAPOLYCYCLIC COMPOUNDS
JP4137645B2 (en) * 2001-05-14 2008-08-20 ファイザー・プロダクツ・インク 5,8,14-Triazatetracyclo [10.3.1.02, 11.04,9] -hexadeca-2 (11), 3,5,7,9-pentane citrate and pharmaceutical composition thereof object
CA2447405C (en) * 2001-05-14 2006-10-17 Pfizer Products Inc. Tartrate salts of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof
ES2258652T3 (en) * 2001-11-29 2006-09-01 Pfizer Products Inc. SUCCINATE SALTS OF 5,8,14-TRIAZATETRACICLO (10.3.1.02,11.04,9) -HEXADECA-2 (11), 3,5,7,9-PENTAENE AND PHARMACEUTICAL COMPOSITIONS OF THE SAME.
PL369886A1 (en) 2001-11-30 2005-05-02 Pfizer Products Inc. Aryl fused azapolycyclic compounds
ES2282492T3 (en) * 2001-11-30 2007-10-16 Pfizer Products Inc. PHARMACEUTICAL COMPOSITIONS OF CONTROLLED LIBERATION ORALS 5,8,14-TRIAZATETRACICLO (10.3.1.0 (2,11) .0 (4,9) -HEXADECA-2 (11) 3,5,7,9-PENTAENO.
US7320788B2 (en) * 2002-02-14 2008-01-22 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for Celiac Sprue
US7303871B2 (en) 2002-02-14 2007-12-04 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for Celiac Sprue
US8143210B2 (en) 2002-02-14 2012-03-27 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
US7265093B2 (en) * 2002-05-14 2007-09-04 The Board Of Trustees Of The Leland Stanford Junior University Drug therapy for Celiac Sprue
US7462688B2 (en) * 2002-05-14 2008-12-09 The Board Of Trustees Of The Leland Stanford Junior University Peptides for diagnostic and therapeutic methods for celiac sprue
US7202216B2 (en) * 2002-05-14 2007-04-10 The Board Of Trustees Of The Leland Stanford Junior University Drug therapy for celiac sprue
WO2003096979A2 (en) * 2002-05-14 2003-11-27 The Board Of Trustees Of The Leland Stanford Junior University Drug therapy for celiac sprue
ATE402134T1 (en) * 2002-11-20 2008-08-15 Pfizer Prod Inc METHOD FOR PRODUCING INDANEOUS-1,3-DICARBONIC ACIDS
ES2383595T3 (en) * 2002-11-20 2012-06-22 The Board Of Trustees Of The Leland Stanford Junior University Celiac disease diagnostic procedure
PL377292A1 (en) * 2002-11-25 2006-01-23 Pfizer Products Inc. Improved process for the preparation of 1,3-substituted indenes
US20070066827A1 (en) * 2003-01-15 2007-03-22 Pfizer Inc. Process for the preparation of aryl fused polycyclic lactams
US20040224962A1 (en) * 2003-05-09 2004-11-11 Pfizer Inc Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss
US20040224963A1 (en) * 2003-05-09 2004-11-11 Pfizer Inc Pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal
JP2006528237A (en) * 2003-05-20 2006-12-14 ファイザー・プロダクツ・インク Pharmaceutical composition of varenicline
WO2004108725A1 (en) * 2003-06-04 2004-12-16 Pfizer Products Inc. Preparation of substituted quinoxalines from the dianline with 2,3-dihydroxy-1,4-dioxane
DE602004023299D1 (en) * 2003-07-21 2009-11-05 Pfizer Prod Inc NICOTINE DEPENDENCE REDUCING HETEROARYL CONDENSED AZAPOLYCYCLIC COMPOUNDS
WO2005007630A2 (en) * 2003-07-21 2005-01-27 Pfizer Products Inc. Aryl fused azapolycyclic compounds
US20050043406A1 (en) * 2003-08-22 2005-02-24 Pfizer Inc Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss
US20050043407A1 (en) * 2003-08-22 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
US7579313B2 (en) 2003-11-18 2009-08-25 The Board Of Trustees Of The Leland Stanford Junior University Transglutaminase inhibitors and methods of use thereof
US7563864B2 (en) * 2004-04-26 2009-07-21 Celiac Sprue Research Foundation Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten
US7534426B2 (en) * 2004-04-26 2009-05-19 The Board Of Trustees Of The Leland Stanford Junior University Glutenase enzyme assays
US7628985B2 (en) * 2004-04-26 2009-12-08 The Board Of Regents Of The Leland Stanford Junior University Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis
WO2006006071A1 (en) * 2004-07-07 2006-01-19 Pfizer Products Inc. Resolution of an aryl-fused azapolycyclic compound
US7766018B2 (en) 2004-09-30 2010-08-03 Smoke-Break, Inc. Device and composition for reducing the incidence of tobacco smoking
BRPI0607838A2 (en) * 2005-02-24 2009-06-13 Pfizer Prod Inc preparation of a substituted high purity quinoxaline
US20060211649A1 (en) * 2005-03-21 2006-09-21 Eric Marchewitz Use of cytisine for enhancing physical performance
EP1976495A2 (en) * 2006-01-06 2008-10-08 Aarhus Universitet Compounds acting on the serotonin transporter
KR20090005305A (en) * 2006-03-27 2009-01-13 화이자 프로덕츠 인크. Varenicline standards and impurity controls
KR20090007568A (en) * 2006-04-24 2009-01-19 화이자 프로덕츠 인코포레이티드 Asymmetric membranes for drug delivery devices
WO2008028903A2 (en) 2006-09-04 2008-03-13 Neurosearch A/S Pharmaceutical combinations of a nicotine receptor modulator and a cognitive enhancer
MX2009005043A (en) * 2006-11-09 2009-05-25 Pfizer Prod Inc Polymorphs of nicotinic intermediates.
CA2680590C (en) * 2007-03-16 2017-10-17 Jonathan David Gass Combination enzyme therapy for digestion of dietary gluten
WO2009034431A2 (en) 2007-09-10 2009-03-19 Pfizer Inc. Controlled-release dosage forms for varenicline
EP2260037A2 (en) * 2008-02-15 2010-12-15 Medichem, S.A. A polymorphic form of a pyrazino [2,3-h] [3] benzazepine derivative
US20090215787A1 (en) * 2008-02-22 2009-08-27 Mai De Ltd. Preparations of new polymorphic forms of varenicline tartrate
US9463190B2 (en) * 2008-03-31 2016-10-11 University Of South Florida Methods of treating disease-induced ataxia and non-ataxic imbalance
WO2009143347A2 (en) * 2008-05-22 2009-11-26 Teva Pharmaceutical Industries Ltd. Varenicline tosylate, an intermediate in the preparation process of varenicline l-tartrate
US20090318460A1 (en) * 2008-05-26 2009-12-24 Glenmark Amorphous varenicline tartrate and process for the preparation thereof
US20090318695A1 (en) * 2008-06-19 2009-12-24 Vinod Kumar Kansal Processes for the preparation of varenicline and intermediates thereof
WO2010005643A1 (en) * 2008-07-10 2010-01-14 Teva Pharmaceutical Industries Ltd. Processes for purifying varenicline l-tartrate salt and preparing crystalline forms of varenicline l-tartrate salt
WO2010023561A1 (en) * 2008-09-01 2010-03-04 Actavis Group Ptc Ehf Process for preparing varenicline, varenicline intermediates, and pharmaceutically acceptable salts thereof
EP2204369A1 (en) 2008-12-22 2010-07-07 Medichem, S.A. Process for preparing varenicline and intermediates for use therein
KR20110132564A (en) 2009-02-11 2011-12-08 선오비온 파마슈티컬스 인코포레이티드 Histamine h3 inverse agonists and antagonists and methods of use thereof
US20120093887A1 (en) 2009-06-10 2012-04-19 Actavis Group Ptc Ehf Amorphous varenicline tartrate co-precipitates
RU2012102052A (en) 2009-06-22 2013-11-20 Тева Фармасьютикал Индастриз Лтд. SOLID FORMS OF VARENIKLIN SALTS AND METHODS FOR THEIR PRODUCTION
WO2011031816A2 (en) * 2009-09-11 2011-03-17 Sepracor Inc. Histamine h3 inverse agonists and antagonists and methods of use thereof
WO2011110954A1 (en) 2010-03-09 2011-09-15 Actavis Group Ptc Ehf Highly pure varenicline or a pharmaceutically acceptable salt thereof substantially free of methylvarenicline impurity
KR101109389B1 (en) * 2010-04-30 2012-01-30 삼성전기주식회사 A printed circuit board and a method of manufacturing the same
WO2011140431A1 (en) 2010-05-06 2011-11-10 Teva Pharmaceutical Industries Ltd. Varenicline salts and crystal forms thereof
US20120004239A1 (en) 2010-06-11 2012-01-05 Medichem, S.A. Process for Preparing Quinoxaline Derivatives
BR112013032044A2 (en) 2011-06-30 2016-12-13 Toray Industries antipruritic
ITMI20111413A1 (en) * 2011-07-28 2013-01-29 Dipharma Francis Srl PROCEDURE FOR THE PREPARATION OF VARENICLINA
ES2426838B1 (en) 2012-04-20 2014-05-07 Genetracer Biotech S.L Method to predict success in quitting tobacco use in response to drug treatment
ES2426517B1 (en) 2012-04-20 2014-05-14 Genetracer Biotech S.L Method to predict the safety of a drug treatment
CN103570502A (en) * 2012-07-18 2014-02-12 上海科胜药物研发有限公司 Preparation method for varenicline intermediate
US9636340B2 (en) 2013-11-12 2017-05-02 Ayyappan K. Rajasekaran Kinase inhibitors
CN103992272B (en) * 2014-06-09 2016-05-11 安徽省逸欣铭医药科技有限公司 A kind of pentazocine hydrochloride ester, Its Preparation Method And Use
KR20160126697A (en) 2015-04-24 2016-11-02 한미정밀화학주식회사 Novel crystalline varenicline oxalate hydrate, preparation method thereof, and pharmaceutical composition comprising same
KR20160143407A (en) 2015-06-05 2016-12-14 한미정밀화학주식회사 Novel varenicline mucate, crystalline form thereof, and method of preparation thereof
KR101724301B1 (en) 2016-11-22 2017-04-10 주식회사 한서켐 Novel crystal form I of varenicline salicylate and its preparing method
CN106674194B (en) * 2016-12-14 2019-03-05 山东省联合农药工业有限公司 A kind of nicotinic insecticide of structure novel and its preparation method and application
JP7137850B2 (en) 2017-03-03 2022-09-15 シーティーシー バイオ インク Formulation for buccal administration comprising an inclusion complex of varenicline or a pharmaceutically acceptable salt thereof
KR102463733B1 (en) 2017-06-30 2022-11-04 한미약품 주식회사 Pharmaceutical composition comprising Varenicline Oxalate with improved content uniformity and stability
WO2018154395A2 (en) 2018-06-11 2018-08-30 Alvogen Malta Operations (Row) Ltd Controlled release pharmaceutical composition of varenicline
KR20200034293A (en) 2018-09-21 2020-03-31 한미약품 주식회사 Varenicline formulation for controlled-release
TW202206078A (en) 2020-04-28 2022-02-16 美商奧伊斯特普安生物製藥公司 Local administration of nicotinic acetylcholine receptor agonists for the inhibition of coronavirus infections
CN113956255A (en) * 2020-07-20 2022-01-21 威智医药有限公司 Preparation method of varenicline intermediate, varenicline and salt thereof
WO2022035434A1 (en) 2020-08-14 2022-02-17 Almatica Pharma Llc Cocrystal of varenicline and oxalic acid, pharmaceutical composition thereof, and methods of use thereof
US11040983B1 (en) 2020-08-14 2021-06-22 Almatica Pharma Llc Cocrystal of varenicline and oxalic acid, pharmaceutical composition thereof, and methods of use thereof
WO2022147189A1 (en) * 2020-12-30 2022-07-07 Antares Pharma, Inc. Varenicline prodrugs
WO2022222019A1 (en) * 2021-04-20 2022-10-27 Suzhou Fude Zhaofeng Biochemical Technology Co., Ltd Total synthesis of varenicline
CN113277993B (en) * 2021-06-06 2023-07-21 湖南第一师范学院 Synthesis method of Tafamidis and derivatives thereof
WO2023275413A2 (en) 2021-12-23 2023-01-05 Medichem, S.A. Solid pharmaceutical formulations of varenicline
EP4241775A1 (en) 2022-03-11 2023-09-13 Par Pharmaceutical, Inc. Tablet comprising varenicline and process of preparation thereof
US11602537B2 (en) 2022-03-11 2023-03-14 Par Pharmaceutical, Inc. Varenicline compound and process of manufacture thereof
WO2023244574A1 (en) 2022-06-14 2023-12-21 Amygdala Neurosciences, Inc. Aldh-2 inhibitor compounds and methods of use
WO2024095172A1 (en) 2022-11-04 2024-05-10 Pfizer Inc. Prodrugs of varenicline and compounds containing vulnerable amines

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3471503A (en) * 1967-05-05 1969-10-07 Mcneilab Inc 1,2,3,5,6,7-hexahydro-4-phenethyl-2,6-methano-4h-4- benzazonin-12-ols
CH644116A5 (en) * 1980-08-21 1984-07-13 Hoffmann La Roche IMIDAZOLE DERIVATIVES.
AU7083596A (en) * 1995-09-22 1997-04-09 Novo Nordisk A/S Novel substituted azacyclic or azabicyclic compounds
DK1044189T4 (en) * 1997-12-31 2015-03-30 Pfizer Prod Inc Aryl-fused fused azapolycyclic connections
US6605610B1 (en) * 1997-12-31 2003-08-12 Pfizer Inc Aryl fused azapolycyclic compounds
AU1918299A (en) * 1998-02-23 1999-09-06 Warner-Lambert Company Substituted quinoxaline derivatives as interleukin-8 receptor antagonists
EP0955301A3 (en) * 1998-04-27 2001-04-18 Pfizer Products Inc. 7-aza-bicyclo[2.2.1]-heptane derivatives, their preparation and use according to their affinity for neuronal nicotinic acetylcholine receptors
DK1076650T3 (en) * 1998-04-29 2004-05-24 Pfizer Prod Inc Aryl fused azapolycyclic compounds
EP1147112B1 (en) * 1999-01-29 2003-10-29 Abbott Laboratories Diazabicyclic derivatives as nicotinic acetylcholine receptor ligands
FR2788982B1 (en) * 1999-02-02 2002-08-02 Synthelabo PHARMACEUTICAL COMPOSITIONS CONTAINING NICOTINE AND THEIR APPLICATION IN SMOKING WITHDRAWAL
IL137937A0 (en) * 1999-08-27 2001-10-31 Pfizer Prod Inc A pharmaceutical composition for the prevention and treatment of nicotine addiction in a mammal
CA2447405C (en) * 2001-05-14 2006-10-17 Pfizer Products Inc. Tartrate salts of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof
JP4137645B2 (en) * 2001-05-14 2008-08-20 ファイザー・プロダクツ・インク 5,8,14-Triazatetracyclo [10.3.1.02, 11.04,9] -hexadeca-2 (11), 3,5,7,9-pentane citrate and pharmaceutical composition thereof object
ES2258652T3 (en) * 2001-11-29 2006-09-01 Pfizer Products Inc. SUCCINATE SALTS OF 5,8,14-TRIAZATETRACICLO (10.3.1.02,11.04,9) -HEXADECA-2 (11), 3,5,7,9-PENTAENE AND PHARMACEUTICAL COMPOSITIONS OF THE SAME.
PL369886A1 (en) * 2001-11-30 2005-05-02 Pfizer Products Inc. Aryl fused azapolycyclic compounds
ES2282492T3 (en) * 2001-11-30 2007-10-16 Pfizer Products Inc. PHARMACEUTICAL COMPOSITIONS OF CONTROLLED LIBERATION ORALS 5,8,14-TRIAZATETRACICLO (10.3.1.0 (2,11) .0 (4,9) -HEXADECA-2 (11) 3,5,7,9-PENTAENO.
WO2005007630A2 (en) * 2003-07-21 2005-01-27 Pfizer Products Inc. Aryl fused azapolycyclic compounds

Also Published As

Publication number Publication date
CN1715280A (en) 2006-01-04
HUS1600018I1 (en) 2018-05-02
OA11428A (en) 2004-05-03
DE69839131D1 (en) 2008-03-27
IL136727A (en) 2006-06-11
AR017967A1 (en) 2001-10-24
PE20000053A1 (en) 2000-02-07
NZ504482A (en) 2003-01-31
DE69839131T3 (en) 2015-05-07
BR9816186B1 (en) 2009-01-13
CN1285821A (en) 2001-02-28
US20020072524A1 (en) 2002-06-13
TNSN98237A1 (en) 2005-03-15
EP1044189B2 (en) 2015-02-25
DE69839131T2 (en) 2009-02-05
FR08C0039I2 (en) 2009-12-18
PT1044189E (en) 2008-04-22
ES2301210T3 (en) 2008-06-16
ES2301210T5 (en) 2015-05-07
HRP20050506A2 (en) 2006-03-31
AU753389B2 (en) 2002-10-17
HUP0100949A3 (en) 2002-12-28
NO20003422L (en) 2000-08-29
US6410550B1 (en) 2002-06-25
CA2316921A1 (en) 1999-07-15
PA8463901A1 (en) 2000-09-29
NO2006016I1 (en) 2006-11-27
CZ20002438A3 (en) 2002-11-13
MY118163A (en) 2004-09-30
KR20010033823A (en) 2001-04-25
JP2002500218A (en) 2002-01-08
JP3550359B2 (en) 2004-08-04
AP1170A (en) 2003-06-30
GT199800200A (en) 2000-06-07
HRP20000445B1 (en) 2009-04-30
LU91442I2 (en) 2008-07-21
BG65058B1 (en) 2007-01-31
BR9814592B1 (en) 2010-06-01
AU753389C (en) 2007-08-09
UA66825C2 (en) 2004-06-15
US6897310B2 (en) 2005-05-24
SI1044189T2 (en) 2015-05-29
AP9801422A0 (en) 1998-12-31
US6951938B2 (en) 2005-10-04
MA26589A1 (en) 2004-12-20
YU40300A (en) 2003-10-31
BR9814592A (en) 2000-10-17
EA003190B1 (en) 2003-02-27
ME00459B (en) 2011-10-10
ZA9811911B (en) 2000-06-29
SK286886B6 (en) 2009-07-06
CO4810373A1 (en) 1999-06-30
NO2006016I2 (en) 2008-10-20
SA99191123B1 (en) 2006-10-02
US6887884B2 (en) 2005-05-03
EP1044189A1 (en) 2000-10-18
KR100408138B1 (en) 2003-12-01
FR08C0039I1 (en) 2008-11-14
RS50069B (en) 2009-01-22
PL209404B1 (en) 2011-08-31
US20070275973A1 (en) 2007-11-29
HN1998000177A (en) 1999-02-09
BG104561A (en) 2001-01-31
US20020132824A1 (en) 2002-09-19
CY1107391T1 (en) 2010-07-28
DK1044189T3 (en) 2008-05-13
US20020111350A1 (en) 2002-08-15
HK1031878A1 (en) 2001-06-29
CZ301925B6 (en) 2010-08-04
ATE386024T1 (en) 2008-03-15
PL341824A1 (en) 2001-05-07
AU9641698A (en) 1999-07-26
US20020072525A1 (en) 2002-06-13
NO319115B1 (en) 2005-06-20
HU230297B1 (en) 2015-12-28
DE122008000038I1 (en) 2008-11-13
CY2008013I1 (en) 2009-11-04
HRP20000445A2 (en) 2001-04-30
HUP0100949A2 (en) 2001-08-28
NL300355I1 (en) 2008-08-01
TW513412B (en) 2002-12-11
EP1659114A3 (en) 2007-01-17
SK9712000A3 (en) 2002-03-05
NL300355I2 (en) 2008-11-03
DK1044189T4 (en) 2015-03-30
EA200000592A1 (en) 2000-12-25
EP1044189B1 (en) 2008-02-13
EG23816A (en) 2007-09-19
TR200001840T2 (en) 2000-12-21
CY2008013I2 (en) 2009-11-04
LU91442I9 (en) 2018-12-31
IS5514A (en) 2000-05-26
SI1044189T1 (en) 2008-06-30
CA2316921C (en) 2004-12-07
EP1659114A2 (en) 2006-05-24
DZ2697A1 (en) 2003-03-29
IL136727A0 (en) 2001-06-14
WO1999035131A1 (en) 1999-07-15
CN1324013C (en) 2007-07-04
SG102686A1 (en) 2004-03-26
NO20003422D0 (en) 2000-06-30

Similar Documents

Publication Publication Date Title
GT199800200AA (en) AZAPOLYCLIC COMPOUNDS CONDENSED WITH ARYL (FRACTIONAL APPLICATION NO. 1, DERIVED FROM PATENT PI-1998-0200).
GT199700079A (en) TRICYCLES DERIVATIVES REPLACED WITH PHENYLAMINE
GT199800058A (en) NICOTINAMIDE DERIVATIVES.
ATE469132T1 (en) SUBSTITUTED 5-ALKINYL-PYRIMIDINES WITH NEUROTROPHIC ACTION
SE9502167L (en) Insulin analog formulations
CR6620A (en) AMINO BICYCLE ACIDS AS PHARMACEUTICAL AGENTS
BR9901279A (en) Replaced tricycles
BR0112337A (en) Phospholipid derivatives of valproic acid and mixtures thereof
PT884316E (en) QUINAZOLIN-4-ONA AS MAP ANTAGONISTS
GT199800205A (en) INDOL 2,3-SUBSTITUTED COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS.
AR028705A1 (en) BIS-ARILSULPHONES
CR10062A (en) COMPOSITIONS AND METHODS OF TREATMENT FOR DISORDERS OF THE CENTRAL NERVOUS SYSTEM
GT199800135A (en) 2 - AMINOPYRIDINES WITH BRANCHED ALCOXY SUBSTITUTES.
DE602004020042D1 (en) he SSRI for the treatment of mood or anxiety disorders
AR010122A1 (en) RECOVERY PROCEDURE FOR HIGHLY PURIFIED VWF OR HIGHLY PURIFIED FACTOR VIII / VWF COMPLEX
BR9911917A (en) Compositions comprising gaba and caffeine analogs
DE60229430D1 (en) (20S) -1 ALPHA-HYDROXY-2-METHYLENE-19-NOR-BISHOMOPREGNACALCIFEROL AND ITS USES
DE69830450D1 (en) Novel Atropisomers of 2,3-Disubstituted- (5,6) -heteroaryl-fused-pyrimidin-4-ones
BR9811821A (en) 2-acylaminopropanamines as tachykinin receptor antagonists
BR0112131A (en) Pharmaceutical Compositions and Methods for Use
PA8642901A1 (en) AMIDAS OF ACID 5 AND 6-AMINOALQUIL INDOL-2-CARBOXILICO 3-SUBSTITUTES AND RELATED ANALOGS AS INHIBITORS OF CASEINA CINASA I
ATE309200T1 (en) ANTICONVULSIVE AND CNS-ACTIVE BIS-FLUORALKYLAMIDES
GT199800147A (en) SUBSTITUTED TETRAHIDRONAFTALENOS AND ANALOG COMPOUNDS.
GT200100184A (en) AMIDAS OF FENILCICLOHEXANOCARBOXILICO SUBSTITUTED ACID AND ITS USE.
BR0210407A (en) Compound, pharmaceutical composition, use of a compound and method of treating a living animal body disorder or disease, including a human