GR880100073A - Retroviral expression vectors and methods for producing hbv antigens - Google Patents

Retroviral expression vectors and methods for producing hbv antigens

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Publication number
GR880100073A
GR880100073A GR880100073A GR880100073A GR880100073A GR 880100073 A GR880100073 A GR 880100073A GR 880100073 A GR880100073 A GR 880100073A GR 880100073 A GR880100073 A GR 880100073A GR 880100073 A GR880100073 A GR 880100073A
Authority
GR
Greece
Prior art keywords
methods
expression vectors
retroviral expression
present
hbv antigens
Prior art date
Application number
GR880100073A
Other languages
Greek (el)
Inventor
Mc Alan Lachlan
R David Milich
Joseph Sorge
Original Assignee
Scripps Clinic Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic Res filed Critical Scripps Clinic Res
Publication of GR880100073A publication Critical patent/GR880100073A/en

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  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η παρούσα εφεύρεσις αφορά εις μόρια DNA εξ ανασυνθέσεως δυνάμενον να εκφράσει τα γονίδια PreS1-PreS2 ή PreCore-Core του HBV εντός κυττάρων σπονδυλωτών οργανισμών, επιμολυνθέντων δι' αυτών. Περιγράφονται επίσης μέθοδοι παραγωγής συνθέσεων παρουσιαζουσών αντιγονικήν ικανότητα των HBsAg και HBeAg δια της χρησιμοποιήσεως κυττάρων επιμολυνθέντων δια των μορίων DNA εξ ανασυνθέσεως της παρούσης εφευρέσεως, ως επίσης τα επιμολυνθέντα κύτταρα και αυταί αύται αι αντιγονικαί συνθέσεις. Περιγράφονται επίσης διαγνωστικά σύνολα των απαραιτήτων υλικών (ΚΙΤS) και εμβόλια περιέχοντα τας αντιγονικάς συνθέσεις της παρούσης εφευρέσεως.ωThe present invention relates to recombinant DNA molecules capable of expressing the PreS1-PreS2 or PreCore-Core genes of HBV in cells of vertebrate organisms infected by them. Also described are methods of producing HBsAg and HBeAg antigenic compositions using cells transfected with the recombinant DNA molecules of the present invention, as well as the transfected cells and these antigenic compositions. Also described are diagnostic kit kits (KITS) and vaccines containing the antigenic compositions of the present invention.

GR880100073A 1987-02-11 1988-02-11 Retroviral expression vectors and methods for producing hbv antigens GR880100073A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1356287A 1987-02-11 1987-02-11

Publications (1)

Publication Number Publication Date
GR880100073A true GR880100073A (en) 1988-12-16

Family

ID=21760585

Family Applications (1)

Application Number Title Priority Date Filing Date
GR880100073A GR880100073A (en) 1987-02-11 1988-02-11 Retroviral expression vectors and methods for producing hbv antigens

Country Status (5)

Country Link
ES (1) ES2009532A6 (en)
GR (1) GR880100073A (en)
NZ (1) NZ223535A (en)
PT (1) PT86744A (en)
ZA (1) ZA88970B (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155198A1 (en) * 1984-02-02 1985-09-18 Institut National De La Sante Et De La Recherche Medicale (Inserm) Yeast cloning and expression vectors for a protein in an eucaryotic cell, containing at least a part of a retrovirus genome; transfected eucaryotic cells; process using these cells and obtained proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155198A1 (en) * 1984-02-02 1985-09-18 Institut National De La Sante Et De La Recherche Medicale (Inserm) Yeast cloning and expression vectors for a protein in an eucaryotic cell, containing at least a part of a retrovirus genome; transfected eucaryotic cells; process using these cells and obtained proteins

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CLAIMS NOT SEARCHED: 13-31 *
CLAIMS SEARCHED: 1-12 *
MOLECULAR AND CELLULAR BIOLOGY, vol. 6, no. 5, May 1986, pages 1393-1400, American Society for Microbiology; M.J. ROOSSINCK et al.: "Expression of hepatitis B viral core region in mammalian cells" *
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 83, March 1986, pages 1578-1582; J.-H. OU et al.: "Hepatitis B virus gene function: The precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen" *
THE JOURNAL OF VIROLOGY, vol. 61, no. 3, March 1987, pages 683-692, American Society for Microbiology; A. McLACHLAN et al.: "Expression of hepatitis B virus surface and core antigens: influences of pre-S and precore sequences" *

Also Published As

Publication number Publication date
ZA88970B (en) 1988-08-10
NZ223535A (en) 1990-05-28
ES2009532A6 (en) 1989-10-01
PT86744A (en) 1989-02-28

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