GR880100073A - Retroviral expression vectors and methods for producing hbv antigens - Google Patents
Retroviral expression vectors and methods for producing hbv antigensInfo
- Publication number
- GR880100073A GR880100073A GR880100073A GR880100073A GR880100073A GR 880100073 A GR880100073 A GR 880100073A GR 880100073 A GR880100073 A GR 880100073A GR 880100073 A GR880100073 A GR 880100073A GR 880100073 A GR880100073 A GR 880100073A
- Authority
- GR
- Greece
- Prior art keywords
- methods
- expression vectors
- retroviral expression
- present
- hbv antigens
- Prior art date
Links
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- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Η παρούσα εφεύρεσις αφορά εις μόρια DNA εξ ανασυνθέσεως δυνάμενον να εκφράσει τα γονίδια PreS1-PreS2 ή PreCore-Core του HBV εντός κυττάρων σπονδυλωτών οργανισμών, επιμολυνθέντων δι' αυτών. Περιγράφονται επίσης μέθοδοι παραγωγής συνθέσεων παρουσιαζουσών αντιγονικήν ικανότητα των HBsAg και HBeAg δια της χρησιμοποιήσεως κυττάρων επιμολυνθέντων δια των μορίων DNA εξ ανασυνθέσεως της παρούσης εφευρέσεως, ως επίσης τα επιμολυνθέντα κύτταρα και αυταί αύται αι αντιγονικαί συνθέσεις. Περιγράφονται επίσης διαγνωστικά σύνολα των απαραιτήτων υλικών (ΚΙΤS) και εμβόλια περιέχοντα τας αντιγονικάς συνθέσεις της παρούσης εφευρέσεως.ωThe present invention relates to recombinant DNA molecules capable of expressing the PreS1-PreS2 or PreCore-Core genes of HBV in cells of vertebrate organisms infected by them. Also described are methods of producing HBsAg and HBeAg antigenic compositions using cells transfected with the recombinant DNA molecules of the present invention, as well as the transfected cells and these antigenic compositions. Also described are diagnostic kit kits (KITS) and vaccines containing the antigenic compositions of the present invention.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1356287A | 1987-02-11 | 1987-02-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
GR880100073A true GR880100073A (en) | 1988-12-16 |
Family
ID=21760585
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR880100073A GR880100073A (en) | 1987-02-11 | 1988-02-11 | Retroviral expression vectors and methods for producing hbv antigens |
Country Status (5)
Country | Link |
---|---|
ES (1) | ES2009532A6 (en) |
GR (1) | GR880100073A (en) |
NZ (1) | NZ223535A (en) |
PT (1) | PT86744A (en) |
ZA (1) | ZA88970B (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0155198A1 (en) * | 1984-02-02 | 1985-09-18 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Yeast cloning and expression vectors for a protein in an eucaryotic cell, containing at least a part of a retrovirus genome; transfected eucaryotic cells; process using these cells and obtained proteins |
-
1988
- 1988-02-10 PT PT8674488A patent/PT86744A/en not_active Application Discontinuation
- 1988-02-11 ES ES8800384A patent/ES2009532A6/en not_active Expired
- 1988-02-11 ZA ZA880970A patent/ZA88970B/en unknown
- 1988-02-11 GR GR880100073A patent/GR880100073A/en unknown
- 1988-02-16 NZ NZ22353588A patent/NZ223535A/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0155198A1 (en) * | 1984-02-02 | 1985-09-18 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Yeast cloning and expression vectors for a protein in an eucaryotic cell, containing at least a part of a retrovirus genome; transfected eucaryotic cells; process using these cells and obtained proteins |
Non-Patent Citations (5)
Title |
---|
CLAIMS NOT SEARCHED: 13-31 * |
CLAIMS SEARCHED: 1-12 * |
MOLECULAR AND CELLULAR BIOLOGY, vol. 6, no. 5, May 1986, pages 1393-1400, American Society for Microbiology; M.J. ROOSSINCK et al.: "Expression of hepatitis B viral core region in mammalian cells" * |
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 83, March 1986, pages 1578-1582; J.-H. OU et al.: "Hepatitis B virus gene function: The precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen" * |
THE JOURNAL OF VIROLOGY, vol. 61, no. 3, March 1987, pages 683-692, American Society for Microbiology; A. McLACHLAN et al.: "Expression of hepatitis B virus surface and core antigens: influences of pre-S and precore sequences" * |
Also Published As
Publication number | Publication date |
---|---|
ZA88970B (en) | 1988-08-10 |
NZ223535A (en) | 1990-05-28 |
ES2009532A6 (en) | 1989-10-01 |
PT86744A (en) | 1989-02-28 |
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