GR77500B - - Google Patents
Info
- Publication number
- GR77500B GR77500B GR71348A GR830171348A GR77500B GR 77500 B GR77500 B GR 77500B GR 71348 A GR71348 A GR 71348A GR 830171348 A GR830171348 A GR 830171348A GR 77500 B GR77500 B GR 77500B
- Authority
- GR
- Greece
- Prior art keywords
- preparation
- biotin
- hydrolyzing
- ester
- intermediates
- Prior art date
Links
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 4
- 229960002685 biotin Drugs 0.000 abstract 2
- 235000020958 biotin Nutrition 0.000 abstract 2
- 239000011616 biotin Substances 0.000 abstract 2
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 229910015900 BF3 Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940068840 d-biotin Drugs 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 150000003557 thiazoles Chemical class 0.000 abstract 1
- 125000001984 thiazolidinyl group Chemical group 0.000 abstract 1
- CBDKQYKMCICBOF-UHFFFAOYSA-N thiazoline Chemical compound C1CN=CS1 CBDKQYKMCICBOF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/379,247 US4468516A (en) | 1982-05-17 | 1982-05-17 | Process for the preparation of biotin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR77500B true GR77500B (el) | 1984-09-24 |
Family
ID=23496439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR71348A GR77500B (el) | 1982-05-17 | 1983-05-13 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4468516A (el) |
| EP (1) | EP0094776B1 (el) |
| JP (1) | JPS58210091A (el) |
| AT (1) | ATE35268T1 (el) |
| AU (1) | AU539264B2 (el) |
| CA (1) | CA1194879A (el) |
| DE (1) | DE3377131D1 (el) |
| DK (1) | DK216883A (el) |
| GR (1) | GR77500B (el) |
| IE (1) | IE55995B1 (el) |
| IN (1) | IN159855B (el) |
| ZA (1) | ZA833472B (el) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4670564A (en) * | 1985-03-14 | 1987-06-02 | Pfizer Inc. | Preparation of thieno-imidazole derivatives |
| DE3776385D1 (de) * | 1986-04-19 | 1992-03-12 | Merck Patent Gmbh | Verfahren zur herstellung von d-(+)-biotin. |
| DE3926690A1 (de) * | 1989-08-12 | 1991-02-14 | Merck Patent Gmbh | Verfahren zur herstellung von d-(+)-biotin |
| DE3928263A1 (de) * | 1989-08-26 | 1991-02-28 | Merck Patent Gmbh | Verfahren zur herstellung von 7-cyan-7,7a-dihydro-1h,3h-imidazol(1,5-c) thiazol-5(6h)-onen |
| EP2633062B1 (en) * | 2010-10-29 | 2017-12-27 | Life Technologies Corporation | Biotin derivatives |
| WO2024250224A1 (en) * | 2023-06-08 | 2024-12-12 | Dsm Ip Assets B.V. | A process for producing a biotin intermediate |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2489235A (en) * | 1947-07-24 | 1949-11-22 | Hoffmann La Roche | Synthesis of biotin |
| US2489236A (en) * | 1947-07-24 | 1949-11-22 | Hoffmann La Roche | Synthesis of biotin and related compounds |
| US4029647A (en) * | 1973-12-03 | 1977-06-14 | Hoffmann-La Roche Inc. | Synthesis of biotin |
| US3978084A (en) * | 1973-12-03 | 1976-08-31 | Hoffmann-La Roche Inc. | Synthesis of biotin |
| US4044020A (en) * | 1975-06-30 | 1977-08-23 | Syntex (U.S.A.) Inc. | Process for preparing biotin |
| US4062868A (en) * | 1977-02-23 | 1977-12-13 | Hoffmann-La Roche Inc. | Synthesis of biotin |
| US4189586A (en) * | 1977-08-05 | 1980-02-19 | Hoffmann-La Roche Inc. | Preparation of biotin |
| DE3122562C1 (de) * | 1981-06-06 | 1982-11-11 | Merck Patent Gmbh, 6100 Darmstadt | Verfahren zur Herstellung von D-(+)-Biotin |
-
1982
- 1982-05-17 US US06/379,247 patent/US4468516A/en not_active Expired - Lifetime
-
1983
- 1983-03-04 IN IN138/DEL/83A patent/IN159855B/en unknown
- 1983-05-09 AT AT83302589T patent/ATE35268T1/de not_active IP Right Cessation
- 1983-05-09 EP EP83302589A patent/EP0094776B1/en not_active Expired
- 1983-05-09 DE DE8383302589T patent/DE3377131D1/de not_active Expired
- 1983-05-13 CA CA000428090A patent/CA1194879A/en not_active Expired
- 1983-05-13 GR GR71348A patent/GR77500B/el unknown
- 1983-05-16 IE IE1133/83A patent/IE55995B1/en not_active IP Right Cessation
- 1983-05-16 AU AU14563/83A patent/AU539264B2/en not_active Ceased
- 1983-05-16 ZA ZA833472A patent/ZA833472B/xx unknown
- 1983-05-16 DK DK216883A patent/DK216883A/da not_active Application Discontinuation
- 1983-05-17 JP JP58086505A patent/JPS58210091A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0348916B2 (el) | 1991-07-25 |
| CA1194879A (en) | 1985-10-08 |
| DK216883A (da) | 1983-12-30 |
| IE831133L (en) | 1983-11-17 |
| IN159855B (el) | 1987-06-13 |
| EP0094776A3 (en) | 1985-06-19 |
| US4468516A (en) | 1984-08-28 |
| AU539264B2 (en) | 1984-09-20 |
| EP0094776B1 (en) | 1988-06-22 |
| ZA833472B (en) | 1984-12-24 |
| ATE35268T1 (de) | 1988-07-15 |
| DK216883D0 (da) | 1983-05-16 |
| DE3377131D1 (en) | 1988-07-28 |
| EP0094776A2 (en) | 1983-11-23 |
| AU1456383A (en) | 1983-11-24 |
| JPS58210091A (ja) | 1983-12-07 |
| IE55995B1 (en) | 1991-03-13 |
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