GR3023060T3 - Process for separating 2-deoxy-2, 2-difluoro-D-ribofuranosyl alkylsulfonate anomers - Google Patents
Process for separating 2-deoxy-2, 2-difluoro-D-ribofuranosyl alkylsulfonate anomersInfo
- Publication number
- GR3023060T3 GR3023060T3 GR970400728T GR970400728T GR3023060T3 GR 3023060 T3 GR3023060 T3 GR 3023060T3 GR 970400728 T GR970400728 T GR 970400728T GR 970400728 T GR970400728 T GR 970400728T GR 3023060 T3 GR3023060 T3 GR 3023060T3
- Authority
- GR
- Greece
- Prior art keywords
- ribofuranosyl
- deoxy
- difluoro
- separating
- anomers
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 2-deoxy-2, 2-difluoro-D-ribofuranosyl alkylsulfonate Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/902,303 US5256797A (en) | 1992-06-22 | 1992-06-22 | Process for separating 2-deoxy-2,2-difluoro-D-ribofuranosyl alkylsulfonate anomers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3023060T3 true GR3023060T3 (en) | 1997-07-30 |
Family
ID=25415647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR970400728T GR3023060T3 (en) | 1992-06-22 | 1997-04-08 | Process for separating 2-deoxy-2, 2-difluoro-D-ribofuranosyl alkylsulfonate anomers |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5256797A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0576232B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JPH0656867A (cg-RX-API-DMAC10.html) |
| KR (1) | KR100302087B1 (cg-RX-API-DMAC10.html) |
| AT (1) | ATE149505T1 (cg-RX-API-DMAC10.html) |
| BR (1) | BR9302426A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2098888C (cg-RX-API-DMAC10.html) |
| CY (1) | CY2091B1 (cg-RX-API-DMAC10.html) |
| DE (1) | DE69308391T2 (cg-RX-API-DMAC10.html) |
| DK (1) | DK0576232T3 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2100462T3 (cg-RX-API-DMAC10.html) |
| GR (1) | GR3023060T3 (cg-RX-API-DMAC10.html) |
| HK (1) | HK1006022A1 (cg-RX-API-DMAC10.html) |
| HU (1) | HU217976B (cg-RX-API-DMAC10.html) |
| IL (1) | IL106074A (cg-RX-API-DMAC10.html) |
| MX (1) | MX9303714A (cg-RX-API-DMAC10.html) |
| TW (1) | TW233300B (cg-RX-API-DMAC10.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL106075A (en) * | 1992-06-22 | 2000-12-06 | Lilly Co Eli | Process for preparing alpha-anomer enriched 1-halo-2-deoxy-2,2-difluoro-alpha-D-erythropentofuranose derivatives |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| EA007867B1 (ru) | 2000-05-26 | 2007-02-27 | Айденикс (Кайман) Лимитед | Композиции для лечения флавивирусных и пестивирусных инфекций и способы их применения |
| US7608600B2 (en) * | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| CN1678326A (zh) | 2002-06-28 | 2005-10-05 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2'－c－甲基－3'－o－l－缬氨酸酯核糖呋喃基胞苷 |
| DK1576138T3 (en) | 2002-11-15 | 2017-05-01 | Idenix Pharmaceuticals Llc | 2'-METHYL NUCLEOSIDES IN COMBINATION WITH INTERFERON AND FLAVIVIRIDAE MUTATION |
| PL377287A1 (pl) | 2002-12-12 | 2006-01-23 | Idenix (Cayman) Limited | Sposób wytwarzania 2'-rozgałęzionych nukleozydów |
| WO2006000922A2 (en) * | 2004-06-23 | 2006-01-05 | Idenix (Cayman) Limited | 5-aza-7-deazapurine derivatives for treating infections with flaviviridae |
| US7214791B2 (en) * | 2004-07-01 | 2007-05-08 | Shenzhen Hande Technology Co., Ltd. | Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material |
| AT502221A1 (de) * | 2005-07-20 | 2007-02-15 | Pharmacon Forschung & Beratung Gmbh | Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung |
| US7781576B2 (en) | 2005-12-23 | 2010-08-24 | Idenix Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
| WO2007092705A2 (en) * | 2006-02-07 | 2007-08-16 | Chemagis Ltd. | Process for preparing gemcitabine and associated intermediates |
| US20070249823A1 (en) * | 2006-04-20 | 2007-10-25 | Chemagis Ltd. | Process for preparing gemcitabine and associated intermediates |
| US20080262215A1 (en) * | 2007-04-23 | 2008-10-23 | Chemagis Ltd. | Gemcitabine production process |
| GB0812895D0 (en) * | 2008-07-15 | 2008-08-20 | Glycom As | Crystalline carbohydrate derivative |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
| ES2157289T3 (es) * | 1987-08-28 | 2001-08-16 | Lilly Co Eli | Procedimiento para la preparacion de 2'-desoxi-2',2'-difluoronucleosidos. |
| US4965374A (en) * | 1987-08-28 | 1990-10-23 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
-
1992
- 1992-06-22 US US07/902,303 patent/US5256797A/en not_active Expired - Lifetime
-
1993
- 1993-06-21 KR KR1019930011306A patent/KR100302087B1/ko not_active Expired - Fee Related
- 1993-06-21 BR BR9302426A patent/BR9302426A/pt not_active Application Discontinuation
- 1993-06-21 DE DE69308391T patent/DE69308391T2/de not_active Expired - Lifetime
- 1993-06-21 HU HU9301826A patent/HU217976B/hu not_active IP Right Cessation
- 1993-06-21 IL IL106074A patent/IL106074A/en not_active IP Right Cessation
- 1993-06-21 EP EP93304821A patent/EP0576232B1/en not_active Expired - Lifetime
- 1993-06-21 CA CA002098888A patent/CA2098888C/en not_active Expired - Lifetime
- 1993-06-21 JP JP5149152A patent/JPH0656867A/ja active Pending
- 1993-06-21 ES ES93304821T patent/ES2100462T3/es not_active Expired - Lifetime
- 1993-06-21 MX MX9303714A patent/MX9303714A/es unknown
- 1993-06-21 AT AT93304821T patent/ATE149505T1/de active
- 1993-06-21 DK DK93304821.7T patent/DK0576232T3/da active
- 1993-06-22 TW TW082104993A patent/TW233300B/zh not_active IP Right Cessation
-
1997
- 1997-04-08 GR GR970400728T patent/GR3023060T3/el unknown
-
1998
- 1998-06-12 HK HK98105211A patent/HK1006022A1/en not_active IP Right Cessation
- 1998-06-18 CY CY9800012A patent/CY2091B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT64551A (en) | 1994-01-28 |
| KR940000473A (ko) | 1994-01-03 |
| ES2100462T3 (es) | 1997-06-16 |
| DE69308391T2 (de) | 1997-07-17 |
| CA2098888A1 (en) | 1993-12-23 |
| EP0576232B1 (en) | 1997-03-05 |
| IL106074A (en) | 1998-02-22 |
| KR100302087B1 (ko) | 2001-10-22 |
| HK1006022A1 (en) | 1999-02-05 |
| DK0576232T3 (da) | 1997-07-21 |
| EP0576232A1 (en) | 1993-12-29 |
| JPH0656867A (ja) | 1994-03-01 |
| BR9302426A (pt) | 1994-01-11 |
| MX9303714A (es) | 1994-01-31 |
| HU217976B (hu) | 2000-05-28 |
| CY2091B1 (en) | 2002-04-05 |
| US5256797A (en) | 1993-10-26 |
| TW233300B (cg-RX-API-DMAC10.html) | 1994-11-01 |
| DE69308391D1 (de) | 1997-04-10 |
| IL106074A0 (en) | 1993-10-20 |
| CA2098888C (en) | 2003-07-29 |
| HU9301826D0 (en) | 1993-09-28 |
| ATE149505T1 (de) | 1997-03-15 |
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