GR3023044T3 - Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors. - Google Patents

Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors.

Info

Publication number
GR3023044T3
GR3023044T3 GR970400711T GR970400711T GR3023044T3 GR 3023044 T3 GR3023044 T3 GR 3023044T3 GR 970400711 T GR970400711 T GR 970400711T GR 970400711 T GR970400711 T GR 970400711T GR 3023044 T3 GR3023044 T3 GR 3023044T3
Authority
GR
Greece
Prior art keywords
sulfamic acid
protease inhibitors
acid derivatives
derivatives useful
retroviral protease
Prior art date
Application number
GR970400711T
Other languages
English (en)
Inventor
Michael L Vazquez
Richard A Mueller
John J Talley
Daniel P Getman
Crescenzo Gary A De
Eric T Sun
Original Assignee
Searle & Co
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co, Monsanto Co filed Critical Searle & Co
Publication of GR3023044T3 publication Critical patent/GR3023044T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GR970400711T 1992-10-30 1997-04-04 Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors. GR3023044T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96968392A 1992-10-30 1992-10-30
PCT/US1993/010460 WO1994010133A1 (en) 1992-10-30 1993-10-29 Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors

Publications (1)

Publication Number Publication Date
GR3023044T3 true GR3023044T3 (en) 1997-07-30

Family

ID=25515855

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970400711T GR3023044T3 (en) 1992-10-30 1997-04-04 Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors.

Country Status (9)

Country Link
EP (1) EP0666841B1 (el)
AT (1) ATE148105T1 (el)
AU (1) AU5589294A (el)
CA (1) CA2141570A1 (el)
DE (1) DE69307726T2 (el)
DK (1) DK0666841T3 (el)
ES (1) ES2097023T3 (el)
GR (1) GR3023044T3 (el)
WO (1) WO1994010133A1 (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4124818B2 (ja) 1995-03-10 2008-07-23 ジー．ディー．サール アンド カンパニー ヘテロシクロカルボニルアミノ酸ヒドロキシエチルアミノスルホンアミドレトロウイルスプロテアーゼインヒビター
US5776971A (en) 1995-03-10 1998-07-07 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6407134B1 (en) 1995-03-10 2002-06-18 G. D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
DE19703713A1 (de) * 1997-01-23 1998-07-30 Hans Prof Dr Schick Verfahren für die Herstellung von Oxetan-2-onen und Zwischenprodukte
US9855230B2 (en) 2014-09-09 2018-01-02 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8800100A (nl) * 1987-01-21 1988-08-16 Sandoz Ag Nieuwe peptidederivaten en werkwijzen voor het bereiden en toepassen van deze derivaten.
DE3830825A1 (de) * 1987-09-15 1989-03-23 Sandoz Ag Hydrophile reninhemmer, ihre herstellung und verwendung
JPH06502859A (ja) * 1990-11-19 1994-03-31 モンサント　カンパニー レトロウイルスプロテアーゼ阻害剤
JPH06502860A (ja) * 1990-11-19 1994-03-31 モンサント　カンパニー レトロウイルス・プロテアーゼ・インヒビター

Also Published As

Publication number Publication date
AU5589294A (en) 1994-05-24
ES2097023T3 (es) 1997-03-16
EP0666841A1 (en) 1995-08-16
EP0666841B1 (en) 1997-01-22
ATE148105T1 (de) 1997-02-15
DE69307726D1 (de) 1997-03-06
WO1994010133A1 (en) 1994-05-11
CA2141570A1 (en) 1994-05-11
DE69307726T2 (de) 1997-06-05
DK0666841T3 (da) 1997-02-10

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