DE69307726D1 - Succinoylaminohydroxyäthylaminosulfamidsäurederivate und ihre verwendung als retrovirale proteasehemmer - Google Patents

Succinoylaminohydroxyäthylaminosulfamidsäurederivate und ihre verwendung als retrovirale proteasehemmer

Info

Publication number
DE69307726D1
DE69307726D1 DE69307726T DE69307726T DE69307726D1 DE 69307726 D1 DE69307726 D1 DE 69307726D1 DE 69307726 T DE69307726 T DE 69307726T DE 69307726 T DE69307726 T DE 69307726T DE 69307726 D1 DE69307726 D1 DE 69307726D1
Authority
DE
Germany
Prior art keywords
succinoylaminohydroxyäthylaminosulfamidic
acid derivatives
protease inhibitor
retroviral protease
retroviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69307726T
Other languages
English (en)
Other versions
DE69307726T2 (de
Inventor
Michael Vazquez
Richard Mueller
John Talley
Daniel Getman
Crescenzo Gary De
Eric Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
GD Searle LLC
Original Assignee
Monsanto Co
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co, GD Searle LLC filed Critical Monsanto Co
Application granted granted Critical
Publication of DE69307726D1 publication Critical patent/DE69307726D1/de
Publication of DE69307726T2 publication Critical patent/DE69307726T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/04—Diamides of sulfuric acids
    • C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69307726T 1992-10-30 1993-10-29 Succinoylaminohydroxyäthylaminosulfamidsäurederivate und ihre verwendung als retrovirale proteasehemmer Expired - Fee Related DE69307726T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96968392A 1992-10-30 1992-10-30
PCT/US1993/010460 WO1994010133A1 (en) 1992-10-30 1993-10-29 Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors

Publications (2)

Publication Number Publication Date
DE69307726D1 true DE69307726D1 (de) 1997-03-06
DE69307726T2 DE69307726T2 (de) 1997-06-05

Family

ID=25515855

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69307726T Expired - Fee Related DE69307726T2 (de) 1992-10-30 1993-10-29 Succinoylaminohydroxyäthylaminosulfamidsäurederivate und ihre verwendung als retrovirale proteasehemmer

Country Status (9)

Country Link
EP (1) EP0666841B1 (de)
AT (1) ATE148105T1 (de)
AU (1) AU5589294A (de)
CA (1) CA2141570A1 (de)
DE (1) DE69307726T2 (de)
DK (1) DK0666841T3 (de)
ES (1) ES2097023T3 (de)
GR (1) GR3023044T3 (de)
WO (1) WO1994010133A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU717598B2 (en) * 1995-03-10 2000-03-30 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5776971A (en) 1995-03-10 1998-07-07 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6407134B1 (en) 1995-03-10 2002-06-18 G. D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
DE19703713A1 (de) * 1997-01-23 1998-07-30 Hans Prof Dr Schick Verfahren für die Herstellung von Oxetan-2-onen und Zwischenprodukte
US9855230B2 (en) 2014-09-09 2018-01-02 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2200115B (en) * 1987-01-21 1990-11-14 Sandoz Ltd Novel peptide derivatives, their production and use
DE3830825A1 (de) * 1987-09-15 1989-03-23 Sandoz Ag Hydrophile reninhemmer, ihre herstellung und verwendung
DE69126987T2 (de) * 1990-11-19 1998-03-05 Monsanto Co Retrovirale protease-inhibitoren
EP0558630B1 (de) * 1990-11-19 1998-04-08 Monsanto Company Retrovirale proteaseinhibitoren

Also Published As

Publication number Publication date
ES2097023T3 (es) 1997-03-16
DE69307726T2 (de) 1997-06-05
AU5589294A (en) 1994-05-24
CA2141570A1 (en) 1994-05-11
WO1994010133A1 (en) 1994-05-11
DK0666841T3 (da) 1997-02-10
EP0666841B1 (de) 1997-01-22
GR3023044T3 (en) 1997-07-30
ATE148105T1 (de) 1997-02-15
EP0666841A1 (de) 1995-08-16

Similar Documents

Publication Publication Date Title
FI950651A0 (fi) Retrovirusproteaasi-inhibiittoreina käyttökelpoisia sulfonyylialkanoyyliaminohydroksietyyliaminosulfoniamideja
DE69332770D1 (de) Sulfonylalkanoylaminohydroxyethylaminosulfamidsäuren verwendbar als retrovirale Proteasehemmer
ATE116640T1 (de) Substituierte pipecoline-säurederivate als hiv- protease-hemmer.
ES2053609T3 (es) Derivados de urea inhibidores de lipoxigenasa.
DK0715618T3 (da) Hydroxyethylaminosulfonamider til anvendelse som inhibitorer af retrovirale proteaser
GR3024181T3 (en) N-(alkanoylamino-2-hydroxypropyl)-sulfonamides useful as retroviral protease inhibitors.
DK0813867T3 (da) Retrovirale proteaseinhibitorer
ATE153670T1 (de) Peptidboronsäurederivate mit protease inhibierenden aktivität
NO934628L (no) Retrovirus-protease-inhibitorer
DE69307726D1 (de) Succinoylaminohydroxyäthylaminosulfamidsäurederivate und ihre verwendung als retrovirale proteasehemmer
DK0937075T3 (da) Hidtil ukendte imidazo- og oxazolopyridiner som phosphodiesteraseinhibitorer
ATE89820T1 (de) 4-amino-3-acylchinolin-derivate, und ihre verwendung als inhibitioren der magensekretion.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee