GR22813B - METHOD OF PREPARATION OF 1 - KETOCYCLODODYKYLO - 2 ACID ACID AND ITS SALTS. - Google Patents

METHOD OF PREPARATION OF 1 - KETOCYCLODODYKYLO - 2 ACID ACID AND ITS SALTS.

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Publication number
GR22813B
GR22813B GR610122813A GR610122813A GR22813B GR 22813 B GR22813 B GR 22813B GR 610122813 A GR610122813 A GR 610122813A GR 610122813 A GR610122813 A GR 610122813A GR 22813 B GR22813 B GR 22813B
Authority
GR
Greece
Prior art keywords
acid
preparation
salts
ketocyclododykylo
nitrile
Prior art date
Application number
GR610122813A
Other languages
Greek (el)
Original Assignee
Chimie Et Atomistique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chimie Et Atomistique filed Critical Chimie Et Atomistique
Priority to GR610122813A priority Critical patent/GR22813B/en
Publication of GR22813B publication Critical patent/GR22813B/en

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Abstract

έθοδος παρασκευής του 1-κετοκυκλοδωδεκυλο-2-οξεικού οξέος του τύπου (Ι) και των θεραπευτικώς χορηγισίμων αλάτων αυτού χαρακτηριζομένη εκ του ότι περιλαμβάνει την σειράν ακολούθων αντιδράσεων: μετατορπή της κυκλοδωδεκανόνης είς 2-διμεθυλαμινομεθυλενοκυκλοδωδεκανόνην-1, μετατροπή είς τατερτοταγές άλας του αμμωνίου της ούτω ληφθείσης τριτοταγούς αμίνης, μετατροπή του τεταρτοταγούς άλατος του αμμωνίου είς νιτρίλιον απολήγοντος είς-2-κυανομεθυλενοκυκλοδωδεκανόνην-1, υδρόλυσιν του ούτω ληφθέντος νιτριλίου διά μιάς αλκαλικής βάσεως με λήψιν ενός αλκαλικού άλατος του 1-κετοκυκλοδωδεκαλο-2-οξεικού οξέος, από του οποίου δύναταί τις να ελευθερώση το οξύ, όπερ δύναται μετέπειτα να αλατοποιηθή διά πάσηςεπιθυμητής βάσεως. Process for the preparation of 1-ketocyclododecyl-2-acetic acid of formula (I) and its therapeutically administrable salts, characterized in that it comprises the following sequence: conversion of cyclododecanone to of the quaternary amine obtained, conversion of the quaternary ammonium salt to nitrile ending in 2-cyanomethylenecyclododecanone-1, hydrolysis of the nitrile thus obtained from the alkyl base 2 to release the acid, which can then be salted to any desired base.

GR610122813A 1961-03-24 1961-03-24 METHOD OF PREPARATION OF 1 - KETOCYCLODODYKYLO - 2 ACID ACID AND ITS SALTS. GR22813B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR610122813A GR22813B (en) 1961-03-24 1961-03-24 METHOD OF PREPARATION OF 1 - KETOCYCLODODYKYLO - 2 ACID ACID AND ITS SALTS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR610122813A GR22813B (en) 1961-03-24 1961-03-24 METHOD OF PREPARATION OF 1 - KETOCYCLODODYKYLO - 2 ACID ACID AND ITS SALTS.

Publications (1)

Publication Number Publication Date
GR22813B true GR22813B (en) 1962-02-03

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ID=36863641

Family Applications (1)

Application Number Title Priority Date Filing Date
GR610122813A GR22813B (en) 1961-03-24 1961-03-24 METHOD OF PREPARATION OF 1 - KETOCYCLODODYKYLO - 2 ACID ACID AND ITS SALTS.

Country Status (1)

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GR (1) GR22813B (en)

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