GR20937B - METHOD OF PREPARATION OF 16-ALKYL-STEROID COMPOUNDS. - Google Patents

METHOD OF PREPARATION OF 16-ALKYL-STEROID COMPOUNDS.

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Publication number
GR20937B
GR20937B GR600120937A GR600120937A GR20937B GR 20937 B GR20937 B GR 20937B GR 600120937 A GR600120937 A GR 600120937A GR 600120937 A GR600120937 A GR 600120937A GR 20937 B GR20937 B GR 20937B
Authority
GR
Greece
Prior art keywords
methylprogesterone
alkyl
preparation
steroid compounds
compound
Prior art date
Application number
GR600120937A
Other languages
Greek (el)
Original Assignee
Merck & Co Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc. filed Critical Merck & Co Inc.
Priority to GR600120937A priority Critical patent/GR20937B/en
Publication of GR20937B publication Critical patent/GR20937B/en

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Abstract

μέθοδος ήτις περιλαμβάνει αντίδρασιν 11α-υδροξυ-16α-μεθυλοπρογεστερόνης μετά αφυδατικού μέσου προςπαραγωγήν Δ9(11)-16α-μεθυλοπρογεστερόνης, κατεργασίαν της ενώσεως ταύτης μετά υπό αλογονιώδους οξέος ένθα το αλογόνον έχει ατομικόν βάρος μεταξύ 35 και 80 προς παραγωγήν της αντιστοίχου 9α-αλογονο-11β-υδροξυ-16α-μεθυλοπρογεστερόνης, στενής επαφής της ενώσεως ταύτης μετά αλκάλεος προς παραγωγήν της 9β,11β-οξειδο-16α-μεθυλοπρογεστερόνης, και αντίδρασιν της ενώσεως ταύτης μετά υδροφθοριδίου προς παραγωγήν 9α-φθοριο-11β-υδροξυ-16α-μεθυλοπρογεστερόνης. process comprising reacting 11α-hydroxy-16α-methylprogesterone with a dehydrating agent to produce Δ9 (11) -16α-methylprogesterone, treating this compound under halogenic acid wherein the halogen has an atomic weight of between 35 and 80 11β-hydroxy-16α-methylprogesterone, in close contact of this compound with an alkali to give 9β, 11β-oxide-16α-methylprogesterone, and reacting this compound with hydrofluoride to give 9α-fluoro-11β-hydroxide-16β-hydroxide.

GR600120937A 1960-01-04 1960-01-04 METHOD OF PREPARATION OF 16-ALKYL-STEROID COMPOUNDS. GR20937B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR600120937A GR20937B (en) 1960-01-04 1960-01-04 METHOD OF PREPARATION OF 16-ALKYL-STEROID COMPOUNDS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR600120937A GR20937B (en) 1960-01-04 1960-01-04 METHOD OF PREPARATION OF 16-ALKYL-STEROID COMPOUNDS.

Publications (1)

Publication Number Publication Date
GR20937B true GR20937B (en) 1960-06-14

Family

ID=36861984

Family Applications (1)

Application Number Title Priority Date Filing Date
GR600120937A GR20937B (en) 1960-01-04 1960-01-04 METHOD OF PREPARATION OF 16-ALKYL-STEROID COMPOUNDS.

Country Status (1)

Country Link
GR (1) GR20937B (en)

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