GR20679B - METHOD FOR THE PREPARATION OF NEW STEROID COMPOUNDS. - Google Patents
METHOD FOR THE PREPARATION OF NEW STEROID COMPOUNDS.Info
- Publication number
- GR20679B GR20679B GR590120679A GR590120679A GR20679B GR 20679 B GR20679 B GR 20679B GR 590120679 A GR590120679 A GR 590120679A GR 590120679 A GR590120679 A GR 590120679A GR 20679 B GR20679 B GR 20679B
- Authority
- GR
- Greece
- Prior art keywords
- compound
- oxygenated
- group
- bromo
- formula
- Prior art date
Links
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- Steroid Compounds (AREA)
Abstract
ία μέθοδος διά την παρασκευήν μιάς ενώσεως της σειράς της 3-οξυγονωθείσης-16-πρεγκνανυ-20-όνης επιλεγομένης εκ της ομάδος ήτις αποτελείται έκ των ενώσεων του τύπου (Ι) είς τον οποίον το R επιλέγεται εκ της ομάδος ήτις αποτελείται εξ υδρογόνου και ακυλίου ήτις περιλαμβάνει την επαφήν μιάς ενώσεως του τύπου (ΙΙ) είς τον οποίον το R έχει την ανωτέρω δοθείσαν σημασίαν μετά επαρκούς ποσότητος βρωμίου πρός σχηματισμόν μιάς 17-βρωμο-3-οξυγονωμένης ενώσεως ήτις έχει είς τον δακτύλιον D τον μερικόν τύπον (ΙΙΙ) είς τον οποίον το Υ είναι είς υποκαταστάτης επιλεγόμενος εκ της ομάδος ήτις αποτελείται εξ υδρογόνου και βρωμίου, την επαφήν της ρηθείσης 17-βρωνο-3-οξυγονωμένης ενώσεως με μίαν ιωδιούχον ένωσιν των μετάλλων των αλκαλιών πρός αντικατάστασινοιωνδήποτε 81-βρωμο-υποκαταστατών διά ιωδίου, σχηματιζομένης ούτω της αντιστοίχου-17-βρωμνο-21-ιωδο-ενώσεως, σχηματιζομένης ούτω της αντιστοίχου 17-βρωμο-21-ιωδο-ενώσεως υπό συνθήκας αντιδράσεως ικανά ίνα προκαλέσουν την αντικατάστασιν του ιωδίου διά υδρογόνου σχηματιζομένης ούτω μίας 17-μονοβρωμο-ενώσεως ήτις έχει είς τον δακτύλιον D τον μερικόν τύπο (ΙV) και την επαφήν της ρηθείσης 17-μονοβρωμο-ενώσεως με ένα παράγονα εφυδροαλογονώσεως πρός παραγωγήν μιάς ενώσεως της σειράς της 3-οξυγονωθείσης 16-πρεγκνενο-20-όνης επιλεγομένης εκ της ομάδος ήτις αποτελείται εξ ενώσεων των τύπων (V), και (VI) ενθα το R έχει την ανωτέρω δοθείσαν σημασίαν. A process for the preparation of a compound of the 3-oxygenated-16-pregnan-20-one series selected from the group consisting of the compounds of formula (I) wherein R is selected from the group consisting of hydrogen and acyl. thus comprising contacting a compound of formula (II) in which R has the above significance after a sufficient amount of bromine to form a 17-bromo-3-oxygenated compound or having in ring D the partial formula (III); wherein Y is a substituent selected from the group consisting of hydrogen and bromine, said contact of said 17-brono-3-oxygenated compound with an iodinated compound of the alkali metals to form any substituents in the form of 81 of the corresponding 17-bromo-21-iodo-compound, thus forming the corresponding 17-bromo-21-iodo-compound under reaction conditions capable of causing iodine to be replaced by iodine of a hydrogen formed thus having a 17-monobromo compound thereof having in ring D the partial formula (IV) and contacting said 17-monobromo compound with a dehydrohalogenating agent to produce a 16-oxygenated 3-oxygenated series compound -one selected from the group it consists of compounds of formulas (V), and (VI) wherein R has the above meaning.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR590120679A GR20679B (en) | 1959-06-26 | 1959-06-26 | METHOD FOR THE PREPARATION OF NEW STEROID COMPOUNDS. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR590120679A GR20679B (en) | 1959-06-26 | 1959-06-26 | METHOD FOR THE PREPARATION OF NEW STEROID COMPOUNDS. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR20679B true GR20679B (en) | 1960-03-23 |
Family
ID=36861743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR590120679A GR20679B (en) | 1959-06-26 | 1959-06-26 | METHOD FOR THE PREPARATION OF NEW STEROID COMPOUNDS. |
Country Status (1)
| Country | Link |
|---|---|
| GR (1) | GR20679B (en) |
-
1959
- 1959-06-26 GR GR590120679A patent/GR20679B/en unknown
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