GR1008348B - Παραγωγα του 3,4-διαμινο βενζοϊκου οξεως ως αναστολεις των αμινοπεπτιδασων του ενδοπλασματικου δικτυου 1,2 (erap1, erap2) και της αμινοπεπτιδασης που ρυθμιζεται απο την ινσουλινη (irap) και χρησεις τους - Google Patents

Παραγωγα του 3,4-διαμινο βενζοϊκου οξεως ως αναστολεις των αμινοπεπτιδασων του ενδοπλασματικου δικτυου 1,2 (erap1, erap2) και της αμινοπεπτιδασης που ρυθμιζεται απο την ινσουλινη (irap) και χρησεις τους

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Publication number
GR1008348B
GR1008348B GR20130100419A GR20130100419A GR1008348B GR 1008348 B GR1008348 B GR 1008348B GR 20130100419 A GR20130100419 A GR 20130100419A GR 20130100419 A GR20130100419 A GR 20130100419A GR 1008348 B GR1008348 B GR 1008348B
Authority
GR
Greece
Prior art keywords
aminopeptidase
inhibitors
erap2
erap1
irap
Prior art date
Application number
GR20130100419A
Other languages
English (en)
Inventor
Αθανασιος Δημητριου Παπακυριακου
Ευθαλια Μιχαηλ Zερβουδη
Στρατικος Δημητριου Ευστρατιος
Διονυσιος Δημητριου Βουρλουμης
Original Assignee
Εκεφε "Δημοκριτος",
Αθανασιος Δημητριου Παπακυριακου
Ευθαλια Μιχαηλ Zερβουδη
Στρατικος Δημητριου Ευστρατιος
Διονυσιος Δημητριου Βουρλουμης
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Εκεφε "Δημοκριτος",, Αθανασιος Δημητριου Παπακυριακου, Ευθαλια Μιχαηλ Zερβουδη, Στρατικος Δημητριου Ευστρατιος, Διονυσιος Δημητριου Βουρλουμης filed Critical Εκεφε "Δημοκριτος",
Priority to GR20130100419A priority Critical patent/GR1008348B/el
Publication of GR1008348B publication Critical patent/GR1008348B/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αφορά στους αναστολείς των αμινοπεπτιδασών του ενδοπλασματικού δικτύου 1, 2 (ERAP1, ERAP2) και της ελεγχόμενης από την Ινσουλίνη αμινοπεπτιδάσης (1RAP) και στις μεθόδους αναστολής τους, όπως και σε συνθέσεις που αποτελούν αναστολείς. Ειδικότερα, οι αναστολείς της παρούσης εφεύρεσης μπορεί να είναι χρήσιμοι σε θεραπεία διαταραχών ή καταστάσεων όπου παρουσιάζεται υπερβολική ή ανεπιθύμητη δραστηριότητα των ERAP1 ή ERAP2 ή IRAP, συμπεριλαμβανομένου του καρκίνου, αυτοάνοσων νοσημάτων, στην αγκυλοποιητική σπονδυλίτιδα και σε άλλες σπονδυλοαρθρίτιδες, στο διαβήτη και στη ρύθμιση της κυτταρικής πρόσληψης της γλυκόζης και ομοιόστασης.
GR20130100419A 2013-07-12 2013-07-12 Παραγωγα του 3,4-διαμινο βενζοϊκου οξεως ως αναστολεις των αμινοπεπτιδασων του ενδοπλασματικου δικτυου 1,2 (erap1, erap2) και της αμινοπεπτιδασης που ρυθμιζεται απο την ινσουλινη (irap) και χρησεις τους GR1008348B (el)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR20130100419A GR1008348B (el) 2013-07-12 2013-07-12 Παραγωγα του 3,4-διαμινο βενζοϊκου οξεως ως αναστολεις των αμινοπεπτιδασων του ενδοπλασματικου δικτυου 1,2 (erap1, erap2) και της αμινοπεπτιδασης που ρυθμιζεται απο την ινσουλινη (irap) και χρησεις τους

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20130100419A GR1008348B (el) 2013-07-12 2013-07-12 Παραγωγα του 3,4-διαμινο βενζοϊκου οξεως ως αναστολεις των αμινοπεπτιδασων του ενδοπλασματικου δικτυου 1,2 (erap1, erap2) και της αμινοπεπτιδασης που ρυθμιζεται απο την ινσουλινη (irap) και χρησεις τους

Publications (1)

Publication Number Publication Date
GR1008348B true GR1008348B (el) 2014-11-11

Family

ID=49920358

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20130100419A GR1008348B (el) 2013-07-12 2013-07-12 Παραγωγα του 3,4-διαμινο βενζοϊκου οξεως ως αναστολεις των αμινοπεπτιδασων του ενδοπλασματικου δικτυου 1,2 (erap1, erap2) και της αμινοπεπτιδασης που ρυθμιζεται απο την ινσουλινη (irap) και χρησεις τους

Country Status (1)

Country Link
GR (1) GR1008348B (el)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003040173A1 (de) * 2001-11-05 2003-05-15 Wilex Ag ANTAGONISTEN FÜR α4-INTEGRINE
EP2551013A1 (en) * 2011-07-27 2013-01-30 Pall Corporation Mixed mode ligands

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003040173A1 (de) * 2001-11-05 2003-05-15 Wilex Ag ANTAGONISTEN FÜR α4-INTEGRINE
EP2551013A1 (en) * 2011-07-27 2013-01-30 Pall Corporation Mixed mode ligands

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
A. PAPAKYRIAKOU ET AL: "Novel selective inhibitors of aminopeptidases that generate antigenic peptides", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, 23 July 2013 (2013-07-23), GBOXFORD, pages 4832 - 4836, XP002719568, ISSN: 0960-894X *
S. K. MAHTO ET AL: "A Reversible Protection Strategy To Improve Fmoc-SPPS of Peptide Thioesters by the N-Acylurea Approach", CHEMBIOCHEM - A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY., vol. 12, 2011, WILEY VCH, WEINHEIM., pages 2488 - 2494, XP002719567, ISSN: 1439-4227 *

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PG Patent granted

Effective date: 20141223

ML Lapse due to non-payment of fees

Effective date: 20160202