GR1005999B - Ανταγωνιστες του υποδοχεα της αγγειοτενσινης με βαση 4(5) υποκατεστημενα ιμιδαζολια, συνθετικες μεθοδοι και διαδερμικη χορηγηση στην θεραπεια της υπερτασης και καρδειοαγγειακων ασθενειων - Google Patents

Ανταγωνιστες του υποδοχεα της αγγειοτενσινης με βαση 4(5) υποκατεστημενα ιμιδαζολια, συνθετικες μεθοδοι και διαδερμικη χορηγηση στην θεραπεια της υπερτασης και καρδειοαγγειακων ασθενειων

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Publication number
GR1005999B
GR1005999B GR20070100312A GR20070100312A GR1005999B GR 1005999 B GR1005999 B GR 1005999B GR 20070100312 A GR20070100312 A GR 20070100312A GR 20070100312 A GR20070100312 A GR 20070100312A GR 1005999 B GR1005999 B GR 1005999B
Authority
GR
Greece
Prior art keywords
angiotensin
receptor antagonists
cardiovascular diseases
transdermal delivery
hypertension
Prior art date
Application number
GR20070100312A
Other languages
English (en)
Inventor
Ιωαννης Ματσουκας
Μιχαηλ Μαραγκουδακης
Δημητριος Βλαχακος
Original Assignee
Ελληνικα Φαρμακα Ερευνα Και Αναπτυξη Eldrug Α.Ε
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ελληνικα Φαρμακα Ερευνα Και Αναπτυξη Eldrug Α.Ε filed Critical Ελληνικα Φαρμακα Ερευνα Και Αναπτυξη Eldrug Α.Ε
Priority to GR20070100312A priority Critical patent/GR1005999B/el
Priority to CA002687975A priority patent/CA2687975A1/en
Priority to EP08789111.5A priority patent/EP2162441B1/en
Priority to PCT/IB2008/002184 priority patent/WO2008142576A2/en
Priority to US12/601,402 priority patent/US8563586B2/en
Priority to BRPI0811264-9A2A priority patent/BRPI0811264A2/pt
Priority to RU2009148050/04A priority patent/RU2009148050A/ru
Priority to KR1020097027055A priority patent/KR20100031113A/ko
Priority to AU2008252485A priority patent/AU2008252485A1/en
Priority to MX2009012755A priority patent/MX2009012755A/es
Priority to JP2010508929A priority patent/JP2010527987A/ja
Priority to CN200880100474.6A priority patent/CN101765590B/zh
Publication of GR1005999B publication Critical patent/GR1005999B/el
Priority to IL202293A priority patent/IL202293A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Αυτή η εφεύρεση παρέχει καινοτομικά 1, 5 και 1, 3, 5 υποκατεστημένα ανάλογα του ιμιδαζολίου ως υδρόφιλους ή λιπόφιλους ανταγωνιστές το Υποδοχέα της ANGII για διαδερμική χρήση. Η καινοτομία αυτή προσφέρει φαρμακευτικές συνθέσεις που περιλαμβάνουν κατάλληλες ενώσεις, διαδικασίες και ενδιάμεσα για τηνπαρασκευή ενώσεων για την θεραπεία της Υπέρτασης.
GR20070100312A 2007-05-24 2007-05-24 Ανταγωνιστες του υποδοχεα της αγγειοτενσινης με βαση 4(5) υποκατεστημενα ιμιδαζολια, συνθετικες μεθοδοι και διαδερμικη χορηγηση στην θεραπεια της υπερτασης και καρδειοαγγειακων ασθενειων GR1005999B (el)

Priority Applications (13)

Application Number Priority Date Filing Date Title
GR20070100312A GR1005999B (el) 2007-05-24 2007-05-24 Ανταγωνιστες του υποδοχεα της αγγειοτενσινης με βαση 4(5) υποκατεστημενα ιμιδαζολια, συνθετικες μεθοδοι και διαδερμικη χορηγηση στην θεραπεια της υπερτασης και καρδειοαγγειακων ασθενειων
BRPI0811264-9A2A BRPI0811264A2 (pt) 2007-05-24 2008-05-23 Compostos
EP08789111.5A EP2162441B1 (en) 2007-05-24 2008-05-23 1,(3,)5-substituted imidazoles, useful in the treatment of hypertension and methods for their preparation
PCT/IB2008/002184 WO2008142576A2 (en) 2007-05-24 2008-05-23 1,(3,)5-substituted imidazoles, their use in the treatment of hypertension and methods for their preparation
US12/601,402 US8563586B2 (en) 2007-05-24 2008-05-23 1,(3,)5-substituted imidazoles, their use in the treatment of hypertension and methods for their preparation
CA002687975A CA2687975A1 (en) 2007-05-24 2008-05-23 1,(3,)5-substituted imidazoles, their use in the treatment of hypertension and methods for their preparation
RU2009148050/04A RU2009148050A (ru) 2007-05-24 2008-05-23 1, (3, )5-замещенные имидазолы, их применение при лечении гипертензии и способы их получения
KR1020097027055A KR20100031113A (ko) 2007-05-24 2008-05-23 1,(3),5-치환된 이미다졸, 이의 고혈압 치료 용도 및 이의 제조 방법
AU2008252485A AU2008252485A1 (en) 2007-05-24 2008-05-23 1,(3,)5-substituted imidazoles, their use in the treatment of hypertension and methods for their preparation
MX2009012755A MX2009012755A (es) 2007-05-24 2008-05-23 Imidazoles 1,(3,)5-substituidos, su uso en el tratamiento de hipertension y metodos para su preparacion.
JP2010508929A JP2010527987A (ja) 2007-05-24 2008-05-23 １，（３，）５−置換イミダゾール類、高血圧症の治療でのそれらの使用及びそれらの調製方法
CN200880100474.6A CN101765590B (zh) 2007-05-24 2008-05-23 1，(3)，5-取代的咪唑、它们在治疗高血压中的用途以及它们的制备方法
IL202293A IL202293A0 (en) 2007-05-24 2009-11-23 1,(,3)5-substituted imidazoles, their use in the treatment of hypertension and methods for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20070100312A GR1005999B (el) 2007-05-24 2007-05-24 Ανταγωνιστες του υποδοχεα της αγγειοτενσινης με βαση 4(5) υποκατεστημενα ιμιδαζολια, συνθετικες μεθοδοι και διαδερμικη χορηγηση στην θεραπεια της υπερτασης και καρδειοαγγειακων ασθενειων

Publications (1)

Publication Number Publication Date
GR1005999B true GR1005999B (el) 2008-07-22

Family

ID=38988332

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20070100312A GR1005999B (el) 2007-05-24 2007-05-24 Ανταγωνιστες του υποδοχεα της αγγειοτενσινης με βαση 4(5) υποκατεστημενα ιμιδαζολια, συνθετικες μεθοδοι και διαδερμικη χορηγηση στην θεραπεια της υπερτασης και καρδειοαγγειακων ασθενειων

Country Status (1)

Country Link
GR (1) GR1005999B (el)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006103068A1 (en) * 2005-04-01 2006-10-05 Lek Pharmaceuticals D.D. A synthesis of 4-bromomethyl-2'-formylbiphenyl and 4-bromomethyl-2'- hydroxymethylbiphenyl and its use in preparation of angiotensin ii antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006103068A1 (en) * 2005-04-01 2006-10-05 Lek Pharmaceuticals D.D. A synthesis of 4-bromomethyl-2'-formylbiphenyl and 4-bromomethyl-2'- hydroxymethylbiphenyl and its use in preparation of angiotensin ii antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JONES J B ET AL: "AKYLATIONS OF THE SIDE-CHAIN NUCLEOPHILES OF CYSTEINE, METHIONINE, HISTIDINE, AND LYSINE DERIVATIVES WITH ALLYL BROMIDE, 1-BROMO-2-BUTYNE, AND 2-BROMOACETOPHENONE", CANADIAN JOURNAL OF CHEMISTRY, NATIONAL RESEARCH COUNCIL. OTTAWA, CA, vol. 59, no. 18, 1971, pages 3012 - 3019, XP008067096, ISSN: 0008-4042 *

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